Through reading and summarizing the relevant literature of bone tissue engineering scaffold materials, the relevant literature was analyzed by bibliometrics and related hot spot visualization, to compare the relevant data of different years, funding institutions, institutions, authors, source publications, countries, literature citations and keywords, so as to provide references for future research on scaffold materials for bone tissue engineering.

The relevant literatures from January 1, 2009 to December 31, 2021 in the Web of Science database were retrieved with the theme of bone tissue engineering and scaffold materials. Applying bibliometric methods, the retrieved relevant data were summarized and drawn by Excel. The literature data were visually analyzed by VOS-viewer software, the research hotspots were interpreted, and the research status and development direction of tissue engineering scaffold materials were analyzed.

A total of 2 145 articles were included after screening. According to bibliometric analysis, the number of papers on scaffold materials for bone tissue engineering was increasing year by year, the number of papers issued in 2020 was the highest (261), accounting for 12.168% of the total. It was predicted that 299 papers would be issued in 2022; In terms of the number of documents issued, National Natural Science Foundation Of China Nsfc was the fund supporting institution with the largest number of documents, with 378; LEAGUE OF EUROPEAN RESEARCH UNIVERSITIES LERU was the organization with the largest number of documents, with a total of 80 articles; Boccaccini AR was the author with the highest number of papers, the total cited frequency was 1 905, and MATERIALS SCIENCE ENGINEERING C MATERIALS FOR BIOLOGICAL APPLICATIONS was the publication with the most publications, with 110 articles accounting for 5.128%; China was the country with the largest number of documents, with up to 608 articles accounting for 28.345%; the most frequently cited document was an article published by Susmita Bose in Trends in Biotechnology. Through literature coupling analysis, it was found that the institutions and countries with the highest correlation strength were the Chinese Academy of Sciences and the United States. Through literature coupling analysis, it was found that the research of bone tissue engineering scaffold materials could be divided into "scaffold material types" "characteristics and preparation required by scaffold materials" and "repair process of scaffold materials" . Comparative analysis by time showed that "3D printing" "mechanical properties" , "hydrogel" and "Silk fibroin" would become the research trends and hotspots in the future. However, hydroxyapatite, biomaterials, in vitro and mechanical properties were the most studied.

In recent years, there are more and more researches on bone tissue engineering scaffolds. Although "3D printing" , "mechanical properties" , "hydrogel" and "silk fibroin" have gradually become research hotspots, there are still few related studies, and there are more and more kinds of scaffolds. However, there are still many shortcomings. In the future, various institutions and countries need to communicate with each other in order to develop more suitable scaffold materials for human body.