探讨臭氧水冲洗在感染创面治疗中的应用，以寻求感染创面治疗的新方法，提高创面愈合质量。

选取2014年4月至2017年10月东南大学医学院附属江阴医院烧伤整形科126例不同病种感染创面的住院患者，应用现配的2 mg/L臭氧水经清创喷头直接冲洗创面，冲洗治疗前和治疗后第4天分别行创面细菌培养，计算创面细菌阳性率、不同细菌检出率、测定创面细菌含量；冲洗治疗前、治疗后第4天分别检测白细胞计数，测定C-反应蛋白(CRP)、降钙素原(PCT)和白细胞介素6(IL-6)；冲洗治疗前和治疗后第4天应用五点口述分级评分法(VRS-5)对创面疼痛进行评分。对数据进行t检验和χ²检验。

全组病例均治愈。创面细菌阳性率由冲洗前的98.7%降为冲洗治疗后的16.7%，差异有统计学意义(χ²＝15.20，P<0.05)；冲洗治疗前和冲洗治疗后第4天，不同菌种检出率比较，差异均有统计学意义(P值均小于0.05)。冲洗治疗后第4天，白细胞计数、CRP、PCT及IL-6分别为(1.0±2.1)×10⁹、(5.1±0.5) mg/L、(6.3±0.6) ng/mL、(6.9±1.2) pg/mL，均明显低于冲洗治疗前(2.3±0.7)×10⁹、(19.0±0.3) mg/L、(13.4±0.5) ng/mL、(48.3±5.1) pg/mL、差异均有统计学意义(t＝2.85、2.79、2.74、2.70，P值均小于0.05)；冲洗治疗前疼痛评分为(2.10±0.03) 分，与臭氧冲洗后第4天评分(2.20±0.40) 分比较，差异无统计学意义(t＝1.98，P>0.05)。

现配现用臭氧水冲洗感染创面具有明显的减轻创面感染作用。

To investigate the application of ozonated water rinse in the treatment of infected wounds, in order to seek new ways to treat infected wounds and improve the quality of wound healing.

A total of 126 patients with burn wounds were selected from April 2014 to October 2017 in the Department of Burns and Plastic Surgery, the Affiliated Jiangyin Hospital of Southeast University Medical College. The wounds were rinsed directly by debridement nozzles with present 2 mg/L ozonated water. Wound surface bacterial culture had been done before and the 4th day after wounds treatment. Bacterial positive rate of the wound was calculated and the detection rate of different bacterial of the wound were also measured. C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6), parallel white blood cell count were measured. Wound pain scores were assessed by 5-point verbal rating scales (VRS-5) before and the 4th day after wounds treatment. The data were analyzed with t test and χ² test.

All the patients were cured. The positive rate of wound bacteria was reduced from 98.7% before rinsing to 16.7% after rinsing, the difference was statistically significant (χ²=15.20, P<0.05). The detection rates of different bacteria before and the 4th day after wounds treatment were significantly different (with P values below 0.05). On the 4th day after treatment, the levels of leucocyte, CRP, PCT and IL-6 were (1.0±2.1)×10^9, (5.1±0.5) mg/L, (6.3 ± 0.6) ng/mL and (6.9±1.2) pg/mL, significantly lower than those before treatment (2.3±0.7)×10^9, (19.0±0.3) mg/L, (13.4±0.5) ng/mL and (48.3±5.1) pg/mL, the differences were statistically significant (t=2.85, 2.79, 2.74, 2.70; with P values below 0.05). The score of pain before the treatment was (2.10 ± 0.03) points and the score was (2.20±0.40) points at the 4th day after treatment. The difference was not statistically significant (t=1.98, P>0.05).

It is found that wound surface rinse with present ozonated water can notably reduce wound infection.