切换至 "中华医学电子期刊资源库"

中华损伤与修复杂志(电子版) ›› 2019, Vol. 14 ›› Issue (06) : 479 -480. doi: 10.3877/cma.j.issn.1673-9450.2019.06.019

所属专题: 文献

视频

一种适用于战创伤致命性大出血止血材料的研发
柴家科1,(), 郭希民2, 沈显贵3   
  1. 1. 100048 北京,解放军总医院第四医学中心全军烧伤研究所
    2. 100850 北京,军事科学院军事医学研究院
    3. 325000 温州,欣乐加生物科技有限公司
  • 出版日期:2019-12-01
  • 通信作者: 柴家科
  • 基金资助:
    军委后勤保障部重大项目(AWS15J003)

Development of a hemostatic material suitable for fatal bleeding in war trauma and injuries

Jiake Chai1(), Ximin Guo2, Xiangui Shen3   

  1. 1. Burn Institute, Fourth Medical Center of PLA General Hospital, Beijing 100048, China
    2. Academy of Military Medical Sciences, 100850 Beijing, China
    3. Xinlejia Biotechnology Co., Ltd., Wenzhou 325000, China
  • Published:2019-12-01
  • Corresponding author: Jiake Chai
引用本文:

柴家科, 郭希民, 沈显贵. 一种适用于战创伤致命性大出血止血材料的研发[J/OL]. 中华损伤与修复杂志(电子版), 2019, 14(06): 479-480.

Jiake Chai, Ximin Guo, Xiangui Shen. Development of a hemostatic material suitable for fatal bleeding in war trauma and injuries[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2019, 14(06): 479-480.

现代科技战争战创伤种类多样、伤情重且复杂。战创伤大出血已成为平战时致残、致死的重要原因。快速止血是战创伤六大救治技术中挽救伤员生命的关键措施之一。无机材料沸石可产生高温造成继发损伤,壳聚糖止血粉在动静脉大出血中止血效果不佳。解放军总医院第四医学中心全军烧伤研究所所长柴家科教授领衔的团队,与军地相关研究机构合作,通过研究弹药火器伤的致伤机制和战创伤救治技术,研制出一种战创伤快速有效止血新材料,并对其结构、理化性能、表征、生物相容性、体外凝血实验等进行评价。本产品具有海绵互穿孔道结构,能成功将聚丙烯酸钠接枝到壳聚糖上,在不同的介质中都具有很强的局部凝血功能、吸水能力,无细胞毒性和致敏性。利用该材料覆盖65 kg白猪股动脉出血、贯穿伤出血和爆炸伤肢体残端出血,按压2~3 min,观察10 min,无继发性出血,止血效果显著。该止血材料通过了产品性能和生物学注册检测,适于平战时伤员大出血止血及自救互救,第一时间挽救生命,为后续救治赢得宝贵时间,明显降低伤亡率、伤残率,提升平战时战创伤救治水平。

Traumas and injuries nowadays in modern wars are full of diversity, severity and complexity. The traumatic hemorrhage has become an important cause of disability and death during the war and the peaceful time. Rapid hemostasis treatment is one of the key measures to save the lives of the wounded in the 6 rescue techniques. Inorganic materials like zeolite could produce secondary damage caused by high temperature. Chitosan hemostatic powder has poor hemostatic effect in arteriovenous hemorrhage. In order to solve the problems of hemostasis treatment, Prof. Chai Jiake, the director of Burn Institute, Fourth Medical Center of the PLA General Hospital, cooperated with military-related research institutes to develop a war wound with fast and effective hemostatic new materials, leading the research on the injury mechanism and battlefield treatment technology of ammunition firearm injuries. The structure, physical and chemical properties, biocompatibility and in vitro coagulation experiments were evaluated. The product has a sponge interpenetrating channel structure, and successfully grafts sodium polyacrylate onto chitosan, which has strong local coagulation ability and water absorption capacity, no cytotoxicity and sensitization. The material was tested on 65 kg pigs to cover the femoral artery, penetration wounds, and the bleeding of the limb of the explosive wounds. The wounds with the materials were all pressed for 2-3 minutes, with no secondary bleeding observed for over 10 minutes. The hemostatic effect was remarkable. The materials, which have passed product performance and biological registration testing, were proved to be suitable for the self-rescue and mutual rescue of the wounded, saving lives at the first time, winning precious time for follow-up treatments. The hemostatic material could significantly reduce the casualties and disability rates, improving the treatment standards and abilities of bleeding.

[1] 周容, 张亚萍, 廖宇, 程晓萍, 管玉龙, 潘广玉, 闫杰, 王贤芝, 苟中山, 潘登科, 李巅远. 超声在基因编辑猪-猴异种并联式心脏移植术中的应用价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(06): 617-623.
[2] 马桥桥, 张传开, 郭开今, 蒋涛, 王子豪, 刘勇, 郝亮. 可降解止血粉减少初次全膝关节置换术失血量的研究[J/OL]. 中华关节外科杂志(电子版), 2024, 18(05): 585-589.
[3] 张秋阳, 余韶芸, 潘向滢, 金家佳, 夏桦, 赵雪红. 成年体外膜肺氧合患者出血影响因素的Meta 分析[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(05): 392-398.
[4] 张舒沁, 陈练. 产后宫腔内妊娠物残留的诊断和临床处理[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 493-497.
[5] 李霞林, 贺芳. 产后出血风险评估和早期预警系统[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 498-503.
[6] 李小飞, 刘洪莉, 石丘玲, 田静, 李莉, 漆洪波, 罗欣. 自然分娩产妇低强度聚焦超声子宫复旧治疗防治产后出血的前瞻性随机对照研究[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 534-539.
[7] 周正阳, 陈凯, 仇多良, 邵乐宁, 吴浩荣, 钟丰云. 腹腔镜腹股沟疝修补术后出血原因分析及处理[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 660-664.
[8] 杭轶, 杨小勇, 李文美, 薛磊. 可控性低中心静脉压技术在肝切除术中应用的最适中心静脉压[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 813-817.
[9] 王永楠, 汤畅通, 殷杰, 谭溢涛. 微创钻孔引流术与神经内镜血肿清除术治疗临界量基底节脑出血的效果对比分析[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(05): 286-292.
[10] 李晓东, 王汉宇, 马龙, 刘亮, 魏云, 李昂. 小脑后下动脉瘤的显微手术治疗[J/OL]. 中华脑科疾病与康复杂志(电子版), 2024, 14(05): 318-320.
[11] 吴广迎, 张延娟, 秦鹏, 卢艳丽. 经颈静脉肝内门体静脉分流术预防上消化道出血的临床研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 545-548.
[12] 梁艳娉, 陈燕柔, 梁运啸, 白飞虎, 吴斌, 王省. 华南地区门静脉高压食管胃静脉曲张出血内镜治疗现状调研分析[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(05): 390-395.
[13] 董晟, 郎胜坤, 葛新, 孙少君, 薛明宇. 反向休克指数乘以格拉斯哥昏迷评分对老年严重创伤患者发生急性创伤性凝血功能障碍的预测价值[J/OL]. 中华临床医师杂志(电子版), 2024, 18(06): 541-547.
[14] 穆巴拉克·伊力哈, 徐霁华, 鲁明. 急性轻型卒中微量脑出血误诊病例的临床特点及影像学表现分析[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 441-445.
[15] 赵伟伟, 赵玉华, 刘小璇. 西藏地区亚甲基四氢叶酸还原酶C677T多态性及其与脑微出血的相关性[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 473-478.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?