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中华损伤与修复杂志(电子版) ›› 2020, Vol. 15 ›› Issue (03) : 166 -169. doi: 10.3877/cma.j.issn.1673-9450.2020.03.002

所属专题: 文献

新型冠状病毒肺炎防控

丙酮酸钠口服补液盐用于治疗新型冠状病毒肺炎的建议
孙永华1,(), 周方强2, 胡森3   
  1. 1. 100035 北京积水潭医院烧伤科
    2. 100039 北京,解放军军事科学院军事医学研究院
    3. 100048 解放军总医院医学创新研究部创伤修复与组织再生研究中心
  • 收稿日期:2020-03-16 出版日期:2020-06-01
  • 通信作者: 孙永华

Recommendations of sodium pyruvate oral rehydration solutions for the treatment of Coronavirus Disease 2019

Yonghua Sun1,(), Fangqiang Zhou2, Sen Hu3   

  1. 1. Department of Burns, Beijing Jishuitan Hospital, Beijing 100035, China
    2. Institute of Military Medicine, Academy of Military Medical Sciences of Chinese People′s Liberation Army, Beijing 100039, China
    3. Research Center of Trauma Repair and Tissue Regeneration, Medical Innovation Research Department, Chinese People′s Liberation Army General Hospital, Beijing 100048, China
  • Received:2020-03-16 Published:2020-06-01
  • Corresponding author: Yonghua Sun
  • About author:
    Corresponding author: Sun Yonghua, Email:
引用本文:

孙永华, 周方强, 胡森. 丙酮酸钠口服补液盐用于治疗新型冠状病毒肺炎的建议[J]. 中华损伤与修复杂志(电子版), 2020, 15(03): 166-169.

Yonghua Sun, Fangqiang Zhou, Sen Hu. Recommendations of sodium pyruvate oral rehydration solutions for the treatment of Coronavirus Disease 2019[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2020, 15(03): 166-169.

新型冠状病毒肺炎给全球带来巨大危害。WHO推荐的口服补液盐(ORS)曾用于腹泻、烧伤的补液治疗和防治非洲埃博拉病毒感染,已充分证明其安全性和有效性。新型冠状病毒肺炎引起过度的全身炎症反应,主要造成肺损伤和呼吸衰竭,治疗对策主要是抗病毒、抗炎和器官支持治疗。笔者研究团队以等分子量丙酮酸盐取代WHO原有碳酸氢盐或枸橼酸盐,制成丙酮酸钠口服补液盐(Pyr-ORS),通过10多年来的系列动物实验,证明Pyr-ORS具有抗缺氧、抗酸、抗炎、增加内脏血流灌注和保护多器官功能等作用,可能在新型冠状病毒肺炎的综合支持治疗中发挥一定的作用,值得推荐。

The outbreak of Coronavirus Disease 2019 has brought harms to worldwide. Oral rehydration solution (ORS) recommended by WHO, has been used in the treatment of diarrhea and burns and to prevent and treat Ebola infections in Africa, strongly illustrating its safety and effectiveness. Coronavirus Disease 2019 causes excessive systemic inflammation, resulting in lung damage and respiratory failure. The therapeutic strategy for Coronavirus Disease 2019 focuses on anti-virus, anti-inflammation and supportive care of organ function. The author research team replaced WHO original bicarbonate or citrate salt with equal molecular weight pyruvic acid salt to make pyruvate oral rehydration solution (Pyr-ORS). Through a series of animal experiments for more than 10 years, it has been proved that Pyr-ORS has the functions of anti-hypoxia, anti-acid, ant-inflammation, increasing visceral blood perfusion and protecting multiple organ functions, etc. It may plays a certain role in the comprehensive supportive treatment of Coronavirus Disease 2019, which is worthy of recommendation.

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