[1] |
Everts P,Onishi K,Jayaram P,et al.Platelet-rich plasma: new performance understandings and therapeutic considerations in 2020[J].Int J Mol Sci,2020,21(20):7794.
|
[2] |
Park YB, Kim JH, Ha CW, et al.Clinical efficacy of plateletrich plasma injection and its association with growth factors in the treatment of mild to moderate knee osteoarthritis: a randomized double-blind controlled clinical trial as compared with hyaluronic acid[J].Am J Sports Med,2021,49(2):487-496.
|
[3] |
Bennell KL,Paterson KL,Metcalf BR,et al.Effect of intraarticular platelet-rich plasma vs placebo injection on pain and medial tibial cartilage volume in patients with knee osteoarthritis:the restore randomized clinical trial[J].JAMA,2021,326(20):2021-2030.
|
[4] |
Wu Z, Yin J, Yue Y, et al.Application effect of different concentrations of platelet-rich plasma combined with quadriceps training on cartilage repair of knee osteoarthritis[J].J Healthc Eng,2022,2022:7878064.
|
[5] |
Jayaram P, Mitchell PJT, Shybut TB, et al.Leukocyte-rich platelet-rich plasma is predominantly anti-inflammatory compared with leukocyte-poor platelet-rich plasma in patients with mildmoderate knee osteoarthritis:a prospective,descriptive laboratory study[J].Am J Sports Med,2023,51(8):2133-2140.
|
[6] |
Birney E.Mendelian randomization[J].Cold Spring Harb Perspect Med,2022,12(4):a041302.
|
[7] |
Smith GD,Ebrahim S.'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? [J].Int J Epidemiol,2003,32(1):1-22.
|
[8] |
Boef AG,Dekkers OM,le Cessie S.Mendelian randomization studies: a review of the approaches used and the quality of reporting[J].Int J Epidemiol,2015,44(2):496-511.
|
[9] |
Gagliano Taliun SA, Evans DM.Ten simple rules for conducting aMendelian randomization study[J].PLoS Comput Biol,2021,17(8):e1009238.
|
[10] |
Sekula P,Del Greco MF,Pattaro C,et al.Mendelian randomization as an approach to assess causality using observational data[J].J Am Soc Nephrol,2016,27(11):3253-3265.
|
[11] |
Tachmazidou I,Hatzikotoulas K,Southam L,et al.Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data[J].Nat Genet,2019,51(2):230-236.
|
[12] |
Zhao JH, Stacey D, Eriksson N, et al.Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets[J].Nat Immunol,2023,24(9):1540-1551.
|
[13] |
Chen Y,Lu T,Pettersson-Kymmer U, et al.Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases[J].Nat Genet,2023,55(1):44-53.
|
[14] |
Skrivankova VW,Richmond RC,Woolf BAR,et al.Strengthening the reporting of observational studies in epidemiology using-Mendelian randomization: the STROBE-MR statement[J].JAMA,2021,326(16):1614-1621.
|
[15] |
Gagnon E, Mitchell PL, Manikpurage HD, et al.Impact of the gut microbiota and associated metabolites on cardiometabolic traits, chronic diseases and human longevity: a Mendelian randomization study[J].J Transl Med,2023,21(1):60.
|
[16] |
Pritchard JK, Przeworski M.Linkage disequilibrium in humans:models and data[J].Am J Hum Genet,2001,69(1):1-14.
|
[17] |
Burgess S,Butterworth A,Thompson SG.Mendelian randomization analysis with multiple genetic variants using summarized data[J].Genet Epidemiol,2013,37(7):658-665.
|
[18] |
Bowden J,Del Greco MF,Minelli C,et al.Assessing the suitability of summary data for two-sampleMendelian randomi-zation analyses using MR-Egger regression:the role of the I2 statistic[J].Int J Epidemiol,2016,45(6):1961-1974.
|
[19] |
Bowden J, Davey Smith G, Burgess S.Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression[J].Int J Epidemiol,2015,44(2):512-525.
|
[20] |
Burgess S,Thompson SG.Interpreting findings from Mendelian randomization using the MR-Egger method[J].Eur J Epidemiol,2017,32(5):377-389.
|
[21] |
Greco M FD,Minelli C,Sheehan NA,et al.Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome[J].Stat Med,2015,34(21):2926-2940.
|
[22] |
Burgess S,Small DS,Thompson SG.A review of instrumental variable estimators for Mendelian randomization[J].Stat Methods Med Res,2017,26(5):2333-2355.
|
[23] |
Hemani G,Bowden J, Davey Smith G.Evaluating the potential role of pleiotropy in Mendelian randomization studies[J].Hum Mol Genet,2018,27(R2):R195-R208.
|
[24] |
Chong J,Wishart DS,Xia J.Using metabo analyst 4.0 for comprehensive and integrative metabolomics data[J].Curr Protoc Bioinformatics,2019,68(1):e86.
|
[25] |
Sobel Michael E.Asymptotic confidence intervals for indirect effects in structural equation models[J].Sociological Methodology,1982,13:290-312.
|
[26] |
Storey JD, Tibshirani R.Statistical significance for genomewide studies[J].Proc Natl Acad Sci U S A,2003,100(16):9440-9445.
|
[27] |
Thien CB,Blystad FD,Zhan Y,et al.Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion[J].EMBO J,2005,24(21):3807-3819.
|
[28] |
Blaize G,Daniels-Treffandier H,Aloulou M,et al.CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens[J].Proc Natl Acad Sci U S A,2020,117(23):12969-12979.
|
[29] |
Kriegova E, Manukyan G, Mikulkova Z, et al.Gender-related differences observed among immune cells in synovial fluid in knee osteoarthritis[J].Osteoarthritis Cartilage,2018,26(9):1247-1256.
|
[30] |
Sohn HS,Choi JW,Jhun J,et al.Tolerogenic nanoparticles induce type Ⅱ collagen-specific regulatory T cells and ameliorate osteoarthritis[J].Sci Adv,2022,8(47):eabo5284.
|
[31] |
Carrion EA,Moses MM,Behringer RR.FGF5[J].Differentiation,2024,139:100736.
|
[32] |
Mohammadi M, Olsen SK, Ibrahimi OA.Structural basis for fibroblast growth factor receptor activation[J].Cytokine Growth Factor Rev,2005,16(2):107-137.
|
[33] |
Pethö-Schramm A, Müller HJ, Paus R.FGF5 and the murine hair cycle[J].Arch Dermatol Res, 1996,288(5-6):264-246.
|
[34] |
Chen M,Lu Y,Liu Y, et al.Injectable microgels with hybrid exosomes of chondrocyte-targeted fgf18 gene-editing and selfrenewable lubrication for osteoarthritis therapy[J].Adv Mater,2024,36(16):e2312559.
|
[35] |
Welhaven HD, Welfley AH, Brahmachary P, et al.Metabolomic profiles and pathways in osteoarthritic human cartilage: a comparative analysis with healthy cartilage[J].Metabolites,2024,14(4):183.
|
[36] |
Li JT,Zeng N,Yan ZP,et al.A review of applications of metabolomics in osteoarthritis[J].Clin Rheumatol,2021,40(7):2569-2579.
|
[37] |
Zhu S,Makosa D,Miller B,et al.Glutathione as a mediator of cartilage oxidative stress resistance and resilience during aging and osteoarthritis[J].Connect Tissue Res,2020,61(1):34-47.
|
[38] |
Kumar P,Liu C,Suliburk J, et al.Supplementingglycine and Nacetylcysteine (GlyNAC) in older adults improves glutathione deficiency,oxidative stress,mitochondrial dysfunction,inflammation,physical function,and aging hallmarks: a randomized clinical trial[J].J Gerontol A Biol Sci Med Sci,2023,78(1):75-89.
|
[39] |
Golovach I,Rekalov D,Akimov OY,et al.Molecular mechanisms and potential applications of chondroitin sulphate in managing post-traumatic osteoarthritis[J].Reumatologia, 2023,61(5):395-407.
|
[40] |
Ootake T,Ishii T,Sueishi K,et al.Effects of mechanical stress and deficiency of dihydrotestosterone or 17β-estradiol on temporomandibular joint osteoarthritis in mice[J].Osteoarthritis Cartilage,2021,29(11):1575-1589.
|
[41] |
Tetlow LC,Woolley DE.Histamine, histamine receptors (H1 and H2), and histidine decarboxylase expression by chondrocytes of osteoarthritic cartilage:an immunohistochemical study[J].Rheumatol Int,2005,26(2):173-178.
|