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中华损伤与修复杂志(电子版) ›› 2015, Vol. 10 ›› Issue (05) : 450 -453. doi: 10.3877/cma.j.issn.1673-9450.2015.05.018

所属专题: 文献

综述

铜绿假单胞菌群体感应抑制剂研究进展
李骏强1, 汤陈琪1, 夏照帆1,()   
  1. 1. 200433 上海,第二军医大学附属长海医院烧伤科
  • 收稿日期:2015-04-07 出版日期:2015-10-01
  • 通信作者: 夏照帆
  • 基金资助:
    中国工程院咨询研究项目(2015-XY-26)

Research progress of pseudomonas aeruginosa quorum sensing inhibitors

Junqiang Li1, Chenqi Tang1, Zhaofan Xia1,()   

  1. 1. Department of Burn, Changhai Hospital, the Second Military University, Shanghai 200433, China
  • Received:2015-04-07 Published:2015-10-01
  • Corresponding author: Zhaofan Xia
  • About author:
    Corresponding author: Xia Zhaofan, Email:
引用本文:

李骏强, 汤陈琪, 夏照帆. 铜绿假单胞菌群体感应抑制剂研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2015, 10(05): 450-453.

Junqiang Li, Chenqi Tang, Zhaofan Xia. Research progress of pseudomonas aeruginosa quorum sensing inhibitors[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2015, 10(05): 450-453.

铜绿假单胞菌是一种条件致病菌,其严重的耐药问题使得传统的抗生素治疗面临挑战。群体感应是一种细胞密度依赖的基因表达现象,控制着铜绿假单胞菌的毒力因子表达和生物膜形成。抑制群体感应能够降低铜绿假单胞菌的毒力作用,且对细菌无选择性压力,不易产生耐药性,是一种潜在的抗感染治疗策略。本文将对近年来铜绿假单胞菌群体感应抑制剂的研究进展作一综述。

Pseudomonas aeruginosa is an opportunistic pathogen with severe antibiotic resistance problems, challenging the use of traditional antibiotics. Quorum sensing is a phenomenon of cell density dependent control of gene expression which controls the expression of virulence factors and biofilm formation in pseudomonas aeruginosa. Inhibition of quorum sensing can reduce the virulence of pseudomonas aeruginosa but shows no selection pressure thus making it a potential anti-infection strategy which is less likely to cause resistance. This review presents the research progress of pseudomonas aeruginosa quorum sensing inhibitors in recent years.

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