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中华损伤与修复杂志(电子版) ›› 2016, Vol. 11 ›› Issue (02) : 147 -150. doi: 10.3877/cma.j.issn.1673-9450.2016.02.015

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综述

急性肺损伤/急性呼吸窘迫综合征与NF-κB信号转导关系的研究进展
舒彬1, 刘真1, 贾赤宇1,()   
  1. 1. 100091 北京,解放军第三〇九医院烧伤整形科
  • 收稿日期:2016-02-10 出版日期:2016-04-01
  • 通信作者: 贾赤宇
  • 基金资助:
    国家自然科学基金面上项目(81372051); 总参军事医学和老年病科研基金项目(ZCWS14B06); 首都临床特色应用研究与成果推广(Z151100004015199); 解放军第三〇九医院院管课题(2014MS-001)

Progress in the research of the relationship between acute lung injury or acute respiratory distress syndrome and nuclear factor kappa B signaling pathway

Bin Shu1, Zhen Liu1, Chiyu Jia1,()   

  1. 1. Department of Burn and Plastic Surgery, the 309th Hospital of People′s Liberation Army, Beijing 100091, China
  • Received:2016-02-10 Published:2016-04-01
  • Corresponding author: Chiyu Jia
  • About author:
    Corresponding author: Jia Chiyu, Email:
引用本文:

舒彬, 刘真, 贾赤宇. 急性肺损伤/急性呼吸窘迫综合征与NF-κB信号转导关系的研究进展[J]. 中华损伤与修复杂志(电子版), 2016, 11(02): 147-150.

Bin Shu, Zhen Liu, Chiyu Jia. Progress in the research of the relationship between acute lung injury or acute respiratory distress syndrome and nuclear factor kappa B signaling pathway[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2016, 11(02): 147-150.

急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)是临床上最常见的急危重症,其发病机制错综复杂,缺乏主动性治疗措施,病死率高。研究表明,核因子κB(NF-κB)为一种诱导型核转录因子,在ALI/ARDS发展过程中发挥极为广泛的功能,并与炎症反应具有密切的关系。现就ALI/ARDS、NF-κB信号转导通路及两者的关系作一简要的论述。

Acute lung injury/acute respiratory distress syndrome is one of the most common clinical emergencies, with a complex pathogenesis, the lack of active treatment measures, high mortality. Nuclear factor kappa B is an inducible nuclear transcription factor. Activation of nuclear factor kappa B signal transduction pathway is involved in a wide range of functions in acute lung injury/acute respiratory distress syndrome and it is closely related with inflammation. This review is about acute lung injury/acute respiratory distress syndrome, nuclear factor kappa B and the relationship between acute lung injury/acute respiratory distress syndrome and nuclear factor kappa B signaling pathway.

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