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中华损伤与修复杂志(电子版) ›› 2018, Vol. 13 ›› Issue (01) : 61 -63. doi: 10.3877/cma.j.issn.1673-9450.2018.01.013

所属专题: 文献

综述

酸性成纤维细胞生长因子修复组织损伤的研究进展
陈郑礼1, 夏照帆1,()   
  1. 1. 200433 上海,海军军医大学长海医院烧伤科,全军烧伤研究所
  • 收稿日期:2017-11-25 出版日期:2018-02-01
  • 通信作者: 夏照帆
  • 基金资助:
    上海市卫生和计划生育委员会科研课题(20174Y0059)

Research progress of acidic fibroblast growth factor in the repair of tissues injury

Zhengli Chen1, Zhaofan Xia1,()   

  1. 1. Department of Burns, Burns Institute, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China
  • Received:2017-11-25 Published:2018-02-01
  • Corresponding author: Zhaofan Xia
  • About author:
    Corresponding author: Xia Zhaofan, Email:
引用本文:

陈郑礼, 夏照帆. 酸性成纤维细胞生长因子修复组织损伤的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2018, 13(01): 61-63.

Zhengli Chen, Zhaofan Xia. Research progress of acidic fibroblast growth factor in the repair of tissues injury[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2018, 13(01): 61-63.

酸性成纤维细胞生长因子(aFGF)于20世纪末就被证实对组织损伤有修复作用,对其结构特点和临床应用的研究在近年取得一定的进展。本文从aFGF的结构特点出发,归纳了其在促进皮肤及黏膜组织创伤愈合作用的相关研究结果,分别阐述了aFGF对皮肤及黏膜组织、烧伤创面、血管损伤、神经组织损伤的修复作用以及减少瘢痕形成的作用,介绍了其作用机制、临床效果及相对于碱性成纤维细胞生长因子的异同。并提出今后对aFGF的研究应聚焦于探索合理的给药方式及时机两方面。

Acidic fibroblast growth factor (aFGF) has been proved to repair the tissue injury at the end of twenty century, and the researches on its structural characteristics and clinical application have made some progress in recent years. Based on the structural features of aFGF, this paper summarizes the results of studies on the role of aFGF in wound healing in the skin and mucosal tissue. The effects of aFGF on wound healing, vascular injury, repair of nerve tissue injury and scar formation are discusses respectively. This paper also introduces the mechanism of action, clinical effects and similarities and differences relative to basic fibroblast growth factor of aFGF. In the future, the exploration of rational methods and time of drug delivery should be focused in the research of aFGF.

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