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中华损伤与修复杂志(电子版) ›› 2018, Vol. 13 ›› Issue (01) : 61 -63. doi: 10.3877/cma.j.issn.1673-9450.2018.01.013

所属专题: 文献

综述

酸性成纤维细胞生长因子修复组织损伤的研究进展
陈郑礼1, 夏照帆1,()   
  1. 1. 200433 上海,海军军医大学长海医院烧伤科,全军烧伤研究所
  • 收稿日期:2017-11-25 出版日期:2018-02-01
  • 通信作者: 夏照帆
  • 基金资助:
    上海市卫生和计划生育委员会科研课题(20174Y0059)

Research progress of acidic fibroblast growth factor in the repair of tissues injury

Zhengli Chen1, Zhaofan Xia1,()   

  1. 1. Department of Burns, Burns Institute, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China
  • Received:2017-11-25 Published:2018-02-01
  • Corresponding author: Zhaofan Xia
  • About author:
    Corresponding author: Xia Zhaofan, Email:
引用本文:

陈郑礼, 夏照帆. 酸性成纤维细胞生长因子修复组织损伤的研究进展[J]. 中华损伤与修复杂志(电子版), 2018, 13(01): 61-63.

Zhengli Chen, Zhaofan Xia. Research progress of acidic fibroblast growth factor in the repair of tissues injury[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2018, 13(01): 61-63.

酸性成纤维细胞生长因子(aFGF)于20世纪末就被证实对组织损伤有修复作用,对其结构特点和临床应用的研究在近年取得一定的进展。本文从aFGF的结构特点出发,归纳了其在促进皮肤及黏膜组织创伤愈合作用的相关研究结果,分别阐述了aFGF对皮肤及黏膜组织、烧伤创面、血管损伤、神经组织损伤的修复作用以及减少瘢痕形成的作用,介绍了其作用机制、临床效果及相对于碱性成纤维细胞生长因子的异同。并提出今后对aFGF的研究应聚焦于探索合理的给药方式及时机两方面。

Acidic fibroblast growth factor (aFGF) has been proved to repair the tissue injury at the end of twenty century, and the researches on its structural characteristics and clinical application have made some progress in recent years. Based on the structural features of aFGF, this paper summarizes the results of studies on the role of aFGF in wound healing in the skin and mucosal tissue. The effects of aFGF on wound healing, vascular injury, repair of nerve tissue injury and scar formation are discusses respectively. This paper also introduces the mechanism of action, clinical effects and similarities and differences relative to basic fibroblast growth factor of aFGF. In the future, the exploration of rational methods and time of drug delivery should be focused in the research of aFGF.

[1]
付小兵. 再论成纤维细胞生长因子与软组织创伤修复[J].中国修复重建外科杂志,2000, 14(5):257-260.
[2]
Wu J, Zhu J, He C, et al. Comparative Study of Heparin-Poloxamer Hydrogel Modified bFGF and aFGF for in Vivo Wound Healing Efficiency[J]. ACS Appl Mater Interfaces, 2016,8(29):18710-18721.
[3]
Mahar PD, Wasiak J, Paul E, et al. Comparing mortality outcomes of major burns and toxic epidermal necrolysis in a tertiary burns centre[J]. Burns, 2014, 40(8):1743-1747.
[4]
孔根现,蒋知新,沙杭,等. 酸性成纤维细胞生长因子与碱性成纤维细胞生长因子生物活性的比较[J]. 中国老年学杂志,2013, 33(24):6173-6175.
[5]
李校堃,许华,付小兵,等. 重组人酸性成纤维细胞生长因子促进创伤愈合的研究[J].中国药科大学学报,2002, 33(4):312-315.
[6]
孙同柱,付小兵,孙晓庆,等. 重组人酸性成纤维细胞生长因子促进皮肤缺损创面愈合的量效关系[J]. 现代康复,2001, 25(18):31-32.
[7]
Li Y, Li G. The expression levels of endogenous aFGF mRNA in microwave burn wound tissues and its clinical significance[J]. J Huazhong Univ Sci Technolog Med Sci, 2007, 27(5):576-578.
[8]
张九恒,徐启文,章发辉. 酸性成纤维细胞生长因子治疗烧伤残余创面的应用[J]. 中国血液流变学杂志,2012, 22(2):292-293.
[9]
马兵,朱世辉,程大胜,等. 重组人酸性成纤维细胞生长因子治疗深Ⅱ度烧伤创面的临床观察[J].中华烧伤杂志,2008, 24(3):223.
[10]
Ma B, Cheng DS, Xia ZF, et al. Randomized, multicenter, double-blind, and placebo-controlled trial using topical recombinant human acidic fibroblast growth factor for deep partial-thickness burns and skin graft donor site[J]. Wound Repair Regen, 2007, 15(6):795-799.
[11]
Zheng L, Hui Q, Tang L, et al. TAT-Mediated Acidic Fibroblast Growth Factor Delivery to the Dermis Improves Wound Healing of Deep Skin Tissue in Rat[J]. PLoS One, 2015, 10(8):e0135291.
[12]
柴家科,孙永华,夏照帆,等. 酸性成纤维细胞生长因子治疗深Ⅱ度烧伤的多中心随机对照临床试验[J]. 中国药师,2015, 18(4):589-591.
[13]
Hoogewef CJ, van Baar ME, Middelkoop E, et al.Impact of official burns:relationship between depressive symptoms, self-esteem and scar severity[J]. Gen Hosp Psychiatry, 2014, 36(3):271-276.
[14]
刘炘,马嵘,马珂,等. 重组人酸性成纤维细胞生长因子对创面愈合的作用[J].中国药科大学学报,2008, 39(1):87-90.
[15]
Mellin TN, Mennie RJ, Cashen DE, et al. Acidic fibroblast growth factor accelerates dermal wound healing[J].Growth Factors, 1992, 7(1):1-14.
[16]
Li XK, Lin ZF, Li Y, et al. Cardiovascular protection of nonmitogenic human acidic fibroblast growth factor from oxidative damage in vitro and in vivo[J]. CardiovascPathol, 2007, 16(2):85-91.
[17]
Kishimoto K, Liu S, Tsuji T, et al. Endogenous angiogenin in endothelial cells is a general requirement for cell proliferation and angiogenesis[J]. Oncogene, 2005, 24(3):445-456.
[18]
Brewster L, Brey EM, Addis M, et al. Improving endothelial healing with novel chimeric mitogens[J]. Am J Surg, 2006, 192(5):589-593.
[19]
Moya ML, Cheng MH, Huang JJ, et al. The effect of FGF-1 loaded alginate microbeads on neovascularization and adipogenesis in a vascular pedicle model of adipose tissue engineering[J]. Biomaterials, 2010, 31(10):2816-2826.
[20]
Cheng X, Wang Z, Yang J, et al. Acidic fibroblast growth factor delivered intranasally induces neurogenesis and angiogenesis in rats after ischemic stroke[J]. Neurol Res, 2011, 33(7):675-680.
[21]
Huang MC, Lo MJ, Lin YL, et al. Functional recovery after the repair of transected cervical roots in the chronic stage of injury[J].J Neurotrauma, 2009, 26(10):1795-1804.
[22]
Huang WC, Kuo HS, Tsai MJ, et al. Adeno-associated virus-mediated human acidic fibroblast growth factor expression promotes functional recovery of spinal cord-contused rats[J]. J Gene Med, 2011, 13(5):283-289.
[23]
张英,闻妍,康媛媛,等. 重组人酸性成纤维细胞生长因子治疗重型口腔溃疡的临床疗效观察[J]. 中国临床药理学杂志,2010, 26(8):627-629.
[24]
Tsai MC, Shen LF, Kuo HS, et al. Involvement of acidic fibroblast growth factor in spinal cord injury repair processes revealed by a proteomics approach[J]. Mol Cell Proteomics, 2008, 7(9):1668-1687.
[25]
Kuo HS, Tsai MJ, Huang MC, et al. Acid fibroblast growth factor and peripheral nerve grafts regulate Th2 cytokine expression, macrophage activation, polyamine synthesis, and neurotrophin expression in transected rat spinal cords[J]. J Neurosci, 2011, 31(11):4137-4147.
[26]
DePaul MA, Lin CY, Silver J, et al. Peripheral Nerve Transplantation Combined with Acidic Fibroblast Growth Factor and Chondroitinase Induces Regeneration and Improves Urinary Function in Complete Spinal Cord Transected Adult Mice[J]. PLoS One, 2015, 10(10):e0139335.
[27]
Lee YS, Lin CY, Caiozzo VJ, et al. Repair of spinal cord transection and its effects on muscle mass and myosin heavy chain isoform phenotype[J]. J Appl Physiol (1985), 2007, 103(5):1808-1814.
[28]
Ni HC, Tseng TC, Chen JR, et al. Fabrication of bioactive conduits containing the fibroblast growth factor 1 and neural stem cells for peripheral nerve regeneration across a 15 mm critical gap[J]. Biofabrication, 2013, 5(3):035010.
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