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中华损伤与修复杂志(电子版)

中华损伤与修复杂志(电子版) ›› 2019, Vol. 14 ›› Issue (02) : 145 -148. doi: 10.3877/cma.j.issn.1673-9450.2019.02.013

所属专题： 文献；

综述

富血小板血浆在风湿性疾病中的研究进展
段姣妞1, 高晋芳2, 张莉芸2,†()   
  1. 1. 030001　太原，山西医科大学附属大医院风湿免疫科
    2. 030032　太原，山西医学科学院　山西大医院风湿免疫科
  • 收稿日期:2019-02-14 出版日期:2019-04-01
  • 通信作者: 张莉芸
  • 基金资助:
    国家自然科学基金(81771768，81202356)

Research progress of platelet-rich plasma in rheumatic diseases

Jiaoniu Duan1, Jinfang Gao2, Liyun Zhang2,†()   

  1. 1. Department of Rheumatology and Immunology, Shanxi Dayi Hospital Affiliated to Shanxi Medical University, Taiyuan 030001, China
    2. Department of Rheumatology and Immunology, Shanxi Dayi Hospital of Shanxi Academy of Medical Sciences, Taiyuan 030032, China
  • Received:2019-02-14 Published:2019-04-01
  • Corresponding author: Liyun Zhang
  • About author:
    Corresponding author: Zhang Liyun, Email:
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段姣妞, 高晋芳, 张莉芸. 富血小板血浆在风湿性疾病中的研究进展[J]. 中华损伤与修复杂志(电子版), 2019, 14(02): 145-148.

Jiaoniu Duan, Jinfang Gao, Liyun Zhang. Research progress of platelet-rich plasma in rheumatic diseases[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2019, 14(02): 145-148.

富血小板血浆(PRP)富含大量生长因子，趋化因子，细胞因子及血浆蛋白，不仅可控制炎症，更有促进组织修复的作用。PRP逐渐成为风湿性疾病治疗的新热点。本文综述了PRP在骨关节炎、类风湿关节炎、干燥综合征、系统性硬化症、结缔组织病相关顽固性皮肤溃疡等疾病中的研究进展。未来需要更多学者积极尝试PRP在其他风湿性疾病中的疗效，同时，PRP联合间充质干细胞治疗在难治性风湿病中具有巨大应用前景。

关键词: 富血小板血浆, 风湿性疾病, 组织, 修复

Platelet-rich plasma(PRP) is enriched by a range of grow factors, chemokines, cytokines, and other plasma proteins, which can suppress inflammation and promote tissue regeneration. The interest in the application of PRP in rheumatology has recently increased. This paper reviews the research progress of PRP in osteoarthritis, rheumatoid arthritis, sjogren′s syndrome, systemic sclerosis, connective tissue disease-associated intractable skin ulcers and so on. In the future, more scholars need to actively try the efficacy of PRP in other rheumatic diseases. At the same time, PRP combined with mesenchymal stem cells has a great application prospect in refractory rheumatic diseases.

Key words: Platelet-rich plasma, Rheumatic diseases, Tissues, Repair
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