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中华损伤与修复杂志(电子版) ›› 2020, Vol. 15 ›› Issue (03) : 219 -222. doi: 10.3877/cma.j.issn.1673-9450.2020.03.014

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综述

ω-3多不饱和脂肪酸对急性肺损伤炎症反应及免疫功能影响的机制研究进展
廖新成1, 郭光华1,()   
  1. 1. 330006 南昌大学第一附属医院烧伤科
  • 收稿日期:2020-03-15 出版日期:2020-06-01
  • 通信作者: 郭光华
  • 基金资助:
    江西省卫生健康委员会科技计划项目(20195183); 江西省教育厅科学技术研究项目(GJJ180127)

Research progress of the influence mechanism of ω-3 polyunsaturated fatty acid on acute lung injury in inflammatory response and immune function

Xincheng Liao1, Guanghua Guo1,()   

  1. 1. Department of Burns, First Affiliated Hospital of Nanchang University, Nanchang 330006, China
  • Received:2020-03-15 Published:2020-06-01
  • Corresponding author: Guanghua Guo
  • About author:
    Corresponding author: Guo Guanghua, Email:
引用本文:

廖新成, 郭光华. ω-3多不饱和脂肪酸对急性肺损伤炎症反应及免疫功能影响的机制研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2020, 15(03): 219-222.

Xincheng Liao, Guanghua Guo. Research progress of the influence mechanism of ω-3 polyunsaturated fatty acid on acute lung injury in inflammatory response and immune function[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2020, 15(03): 219-222.

烧(创)伤、吸入性损伤、严重感染以及休克等疾病过程中,机体内多种炎性介质的释放,引发炎性细胞向肺组织迁移,激活呈级联放大的炎症反应,常常可造成以肺毛细血管内皮细胞和肺泡上皮细胞损伤为主的急性肺损伤(ALI),严重者短时间内可迅速发展为急性呼吸窘迫综合征(ARDS),病死率极高。ω-3多不饱和脂肪酸(ω-3PUFA)作为药理性免疫营养素的重要组成部分,目前已经超越了以往单纯提供能量、恢复正氮平衡的范畴,发挥着调控机体炎症反应、免疫功能的全面作用,并逐渐演变为现代危重性肺损伤治疗的重要组成部分。因此,本文就ω-3PUFA对ALI炎症反应及免疫功能影响的机制作一综述,旨在为临床治疗ALI提供理论依据。

In the process of diseases such as burns (trauma), inhalation injury, severe infection and shock, the release of a variety of inflammatory mediators in the body triggers the migration of inflammatory cells to lung tissue and activate an inflammatory reaction with cascade amplification, which often cause acute lung injury (ALI) mainly with damage to pulmonary capillary endothelial cells and alveolar epithelial cells. Severe cases can rapidly develop into acute respiratory distress syndrome (ARDS) in a short period of time with extremely high fatality rate. ω-3 polyunsaturated fatty acid (ω-3PUFA), as an important component of pharmacological immune nutrients, has now gone beyond the previous category of simply providing energy and restoring positive nitrogen balance. It plays a comprehensive role in regulating inflammation, immune function, and gradually evolves into an important component of modern critically ill lung injury treatment. Therefore, this article reviews the mechanism and anti-inflammatory mechanism of ω-3PUFA on ALI inflammatory response and immune function, aiming to provide theoretical basis for clinical treatment of ALI.

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