切换至 "中华医学电子期刊资源库"

中华损伤与修复杂志(电子版) ›› 2020, Vol. 15 ›› Issue (04) : 264 -267. doi: 10.3877/cma.j.issn.1673-9450.2020.04.006

所属专题: 文献 指南共识

指南与共识

瘢痕癌性溃疡诊断与治疗专家共识(2020年版)
张家平1,(), 江旭品1   
  1. 1. 陆军军医大学(第三军医大学)第一附属医院
  • 收稿日期:2020-07-12 出版日期:2020-08-01
  • 通信作者: 张家平

Expert consensus on diagnosis and treatment of Marjolin ulcer (2020 version)

Jiaping Zhang1,(), Xupin Jiang1   

  1. 1. First Affiliated Hospital of Army Medical University (Third Military Medical University)
  • Received:2020-07-12 Published:2020-08-01
  • Corresponding author: Jiaping Zhang
  • About author:

    Proof Writing:

    Proof Writing:

    Corresponding author: Zhang Jiaping, 400038 Chongqing, State Key Laboratory of Trauma, Burn and Combined Injury, Department of Plastic and Aesthetic Surgery, First Affiliated Hospital of Army Medical University (Third Military Medical University), Email: ;
    Huang Yuesheng, 518020 Shenzhen, Department of Wound Repair, Institute of Wound Repair, Shenzhen People′s Hospital, First Affiliated Hospital of Southern University of Science and Technology, Second Clinical Medical College of Jinan University, Email:
引用本文:

张家平, 江旭品. 瘢痕癌性溃疡诊断与治疗专家共识(2020年版)[J]. 中华损伤与修复杂志(电子版), 2020, 15(04): 264-267.

Jiaping Zhang, Xupin Jiang. Expert consensus on diagnosis and treatment of Marjolin ulcer (2020 version)[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2020, 15(04): 264-267.

瘢痕癌,又被称为马氏溃疡,往往是在瘢痕溃疡的基础上恶变而成,其临床表现为溃疡长期不能愈合。瘢痕癌的致病因素与发生机制尚不十分清楚,但瘢痕反复破溃、糜烂、合并感染等慢性刺激在其病理发展中具有重要意义。目前,有关瘢痕癌的诊疗方案尚未形成统一认识。本文以国内外文献为基础,以全国相关领域专家的临床经验与观点为主要依据,在瘢痕癌性溃疡的病因、病理、临床表现、诊断与鉴别诊断、预防和治疗等方面汇集形成专家共识,为瘢痕癌性溃疡的防治提供参考。

Scar carcinoma, also named as Marjolin ulcer, is commonly derived from the malignant transformation of scar ulcer with its non-healing as the main clinic manifestation. Although the factors and mechanisms of scar carcinoma are not very clear, chronic stimulations such as repeated rupture, erosion and infection of scars play an important role in its pathogenesis. Currently, no consensus on the diagnosis and treatment of scar carcinoma has been developed. Based on the literature and the clinical experience and viewpoints of experts, we developed a consensus regarding on the etiology, pathology, clinical manifestation, diagnosis, prevention and treatment of scar carcinoma, so as to provide helpful reference for its prevention and treatment in clinic.

[1]
Lindelöf B, Krynitz B, Granath F, et al. Burn injuries and skin cancer: a population- based cohort study[J]. Acta Derm Venereol, 2008, 88(1): 20-22.
[2]
Copcu E. Marjolin′s ulcer: a preventable complication of burns[J]. Plast Reconstr Surg, 2009, 124(1): 156e-164e.
[3]
Kowal-Vern A, Criswell BK. Burn scar neoplasms: A literature review and statistical analysis[J]. Burns, 2005, 31(4): 403-413.
[4]
邱丙森. 鳞状细胞癌[M]// 杨国亮,王侠生. 现代皮肤病学. 上海:上海医科大学出版社,1996: 945-975.
[5]
Kasse AA, Betel E, Dem A, et al. Cancers in the scars of thermal burns (apropos of 67 cases)[J]. Dakar Med, 1999, 44(2): 206-210.
[6]
Guenther N, Menenakos C, Braumann C, et al. Squamous cell carcinoma arising on a skin graft 64 years after primary injury[J]. Dermatol Online J, 2007, 13(2): 27.
[7]
Fleming MD, Hunt JL, Purdue GF, et al. Marjolin′s ulcer: a review and reevaluation of a difficult problem[J]. J Burn Care Rehabil, 1990, 11(5): 460-469.
[8]
Trent JT, Kirsner RS. Wounds and malignancy[J]. Adv Skin Wound Care, 2003, 16(1): 31-34.
[9]
O′Byrne KJ, Dalgleish AG. Chronic immune activation and inflammation as the cause of malignancy[J]. Br J Cancer, 2001, 85(4): 473-483.
[10]
刘梅,赵琰,何春涤,等. 皮肤瘢痕癌45例回顾性分析[J]. 中国美容医学,2010, 19(4): 540-542.
[11]
Aydoğdu E, Yildirim S, Aköz T. Is surgery an effective and adequate treatment in advanced marjolin′ s ulcer?[J]. Burns, 2005, 31(4): 421-431.
[12]
Sawhney S, Jain R, Kakaria A, et al. Marjolin′s ulcer: radiographic and magnetic resonance appearances in two cases[J]. Sultan Qaboos Univ Med J, 2009, 9(2): 162-166.
[13]
梁伟强,张金明,潘淑娟,等. 烧伤后瘢痕癌七例的临床分析[J/CD]. 中华临床医师杂志(电子版), 2011, 5(6): 1776-1778.
[14]
Huang CY, Feng CH, Hsiao YC, et al. Burn scar carcinoma[J]. J Dermatolog Treat, 2010, 21(6): 350-356.
[15]
李晖,武斌,陈晓泉. 瘢痕癌临床治疗分析[J]. 现代肿瘤医学,2008, 16(9): 1553-1554.
[16]
张鲜英,刘毅,肖斌,等. 皮肤鳞状细胞癌的外科治疗[J]. 临床肿瘤学杂志,2012, 17(12): 1105-1107.
[17]
谢尔凡,黎鳌. 烧伤瘢痕癌国外进展[J]. 中华整形烧伤外科杂志,1993, 9(6): 430-432.
[18]
汤培,李金树,黄道强,等. 烧伤瘢痕癌治疗分析[J]. 中国医师进修杂志,2006, 29(30): 31-32.
[19]
Ozek C, Cankayali R, Bilkay U, et al. Marjolin′s ulcers arising in burn scars[J]. J Burn Care Rehabil, 2001, 22(6): 384-389.
[20]
LeBoeuf NR, Schmults CD. Update on the management of high-risk squamous cell carcinoma[J]. Semin Cutan Med Surg, 2011, 30(1): 26-34.
[21]
Pekarek B, Buck S, Osher L. A Comprehensive Review on Marjolin′s Ulcers: Diagnosis and Treatment[J]. J Am Coll Clin Wound Spec, 2011, 3(3): 60-64.
[22]
龙忠恒,谢卫国. 瘢痕癌研究进展[J]. 中华烧伤杂志,2014, 30(6): 495-499.
[23]
Edwards MJ, Hirsch RM, Broadwater JR, et al. Squamous cell carcinoma arising in previously burned or irradiated skin[J]. Arch Surg, 1989, 124(1): 115-117.
[1] 中华医学会烧伤外科学分会小儿烧伤学组. 儿童烧伤早期休克液体复苏专家共识(2023版)[J]. 中华损伤与修复杂志(电子版), 2023, 18(05): 371-376.
[2] 中国老年医学学会烧创伤分会, 中国生物材料学会烧创伤创面修复材料分会. 中国糖尿病足截肢(趾)治疗专家共识(2022年版)[J]. 中华损伤与修复杂志(电子版), 2023, 18(01): 1-9.
[3] 中国肾移植供体来源游离DNA应用与研究专家组, 中国医药生物技术协会移植技术分会. 供体来源游离DNA检测在肾移植中临床应用的专家共识(2022版)[J]. 中华移植杂志(电子版), 2022, 16(05): 257-265.
[4] 广东省医疗行业协会泌尿外科管理分会. 老年尿失禁护理专家共识[J]. 中华腔镜泌尿外科杂志(电子版), 2022, 16(05): 389-393.
[5] 李咏生, 孙建国, 李梦侠, 重庆肺癌精准治疗协作组(CPLOG). 第三代EGFR-TKI耐药后诊疗策略专家共识[J]. 中华肺部疾病杂志(电子版), 2023, 16(02): 145-155.
[6] 中国呼吸医师协会介入委员会胸膜疾病专业组. 内科胸腔镜下光动力治疗胸膜肿瘤的专家共识[J]. 中华肺部疾病杂志(电子版), 2022, 15(05): 615-620.
[7] 李其鑫, 陈蔚. 关注数字疗法在眼健康领域的应用[J]. 中华眼科医学杂志(电子版), 2023, 13(03): 129-133.
[8] 刘玲, 李绪言, 徐永昊, 赵慧颖, 罗巧侠, 欧晓峰, 宋雷, 程渊, 周娟, 曾以萍, 刘爱华, 边巴穷达, 张烁, 吕杰, 王玺, 鲁燕云, 陈佰绪, 达珍, 俞云, 邵佳, 中华医学会重症医学分会重症呼吸学组, 西藏医学会高原医学暨心血管专业委员会, 中国医师协会重症医学医师分会. 高原地区新型冠状病毒肺炎重症患者(重型/危重型)诊疗专家共识[J]. 中华重症医学电子杂志, 2022, 08(04): 340-346.
[9] 静脉淋巴功能不全临床专家共识编写组. 静脉淋巴功能不全临床专家共识[J]. 中华临床医师杂志(电子版), 2023, 17(06): 630-638.
[10] 中国老年医学学会麻醉学分会. 老年患者术后肺部并发症防治专家共识[J]. 中华临床医师杂志(电子版), 2023, 17(01): 7-22.
[11] 杨旭希, 郑吉洋, 陈秀梅, 陈淑玲, 杨峻青, 苏芝琪, 左咏臻, 广东省医师协会心力衰竭专业医师分会, 广东省护士协会介入护士分会. 慢性心力衰竭患者容量管理护理专家共识[J]. 中华介入放射学电子杂志, 2023, 11(03): 201-207.
[12] 中华医学会心电生理和起搏分会, 中国医师协会心律学专业委员会. 普通心脏起搏器和植入型心律转复除颤器手术操作规范中国专家共识(2023)[J]. 中华心脏与心律电子杂志, 2023, 11(02): 65-102.
[13] 中华医学会消化内镜学分会护理协作组. 消化内镜中心的环境与布局专家共识建议(2023年,北京)[J]. 中华胃肠内镜电子杂志, 2023, 10(04): 240-247.
[14] 中华医学会消化内镜学分会. 中国结直肠息肉冷切专家共识(2023年,杭州)[J]. 中华胃肠内镜电子杂志, 2023, 10(02): 73-82.
[15] 中国医师协会外科医师分会肥胖和糖尿病外科医师委员会, 中国肥胖代谢外科研究协作组. 肥胖代谢外科个案管理术前临床路径中国专家共识(2023版)[J]. 中华肥胖与代谢病电子杂志, 2023, 09(02): 73-82.
阅读次数
全文


摘要