切换至 "中华医学电子期刊资源库"

中华损伤与修复杂志(电子版) ›› 2023, Vol. 18 ›› Issue (05) : 447 -450. doi: 10.3877/cma.j.issn.1673-9450.2023.05.015

综述

药物相关坏疽性脓皮病的研究进展
陆美琪, 赵洁, 单菲, 王兴蕾, 姜笃银()   
  1. 250033 济南,山东大学第二医院整形烧伤科
    250033 济南,山东大学第二医院急诊医学中心
    250033 济南,山东大学第二医院整形烧伤科;250033 济南,山东大学第二医院急诊医学中心
  • 收稿日期:2023-03-10 出版日期:2023-10-01
  • 通信作者: 姜笃银
  • 基金资助:
    国家自然科学基金(81873934); 王正国创伤医学发展基金会(SZYZ-TR-09); 山东大学临床研究中心急危重症重点专项(2021SDUCRCA008); 山东省科技攻关项目(2019GGX105011); 济南市科技计划项目(202225065)

Research progress of drug-induced pyoderma gangrenosum

Meiqi Lu, Jie Zhao, Fei Shan, Xinglei Wang, Duyin Jiang()   

  1. Department of Burns and Plastic Surgery, the Second Hospital of Shandong University, Jinan 250033, China
    Department of Emergency Medical Center, the Second Hospital of Shandong University, Jinan 250033, China
    Department of Burns and Plastic Surgery, the Second Hospital of Shandong University, Jinan 250033, China; Department of Emergency Medical Center, the Second Hospital of Shandong University, Jinan 250033, China
  • Received:2023-03-10 Published:2023-10-01
  • Corresponding author: Duyin Jiang
引用本文:

陆美琪, 赵洁, 单菲, 王兴蕾, 姜笃银. 药物相关坏疽性脓皮病的研究进展[J]. 中华损伤与修复杂志(电子版), 2023, 18(05): 447-450.

Meiqi Lu, Jie Zhao, Fei Shan, Xinglei Wang, Duyin Jiang. Research progress of drug-induced pyoderma gangrenosum[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2023, 18(05): 447-450.

药物相关坏疽性脓皮病是一种极其罕见的嗜中性皮肤病,病理生理机制不清,诊断困难,且无统一的治疗方案。药物诱发的坏疽性脓皮病作为一种罕见的药物不良反应常给患者带来极大的痛苦。本文就药物相关坏疽性脓皮病的发病机制、病理学检查、临床表现、诊断与鉴别诊断、治疗方案等方面进行综述,以期为临床工作中药物相关坏疽性脓皮病的诊断与治疗提供参考。

Drug-induced pyoderma gangrenosum is an extremely rare neutrophilic dermatoses with unclear pathophysiology, difficult diagnosis and non-uniform treatment protocol. However, drug-induced pyoderma gangrenosum is a rare adverse drug reaction that often causes great suffering to patients. In this article, the pathogenesis, pathological examination, clinical manifestations, diagnosis and differential diagnosis, and treatment options of drug-induced pyoderma gangrenosum were reviewed, with the aim of providing a reference for the diagnosis and treatment of drug-induced pyoderma gangrenosum in clinical practice.

[1]
Wallach D, Vignon-Pennamen MD. Pyoderma gangrenosum and Sweet syndrome: the prototypic neutrophilic dermatoses[J]. Br J Dermatol, 2018, 178(3): 595-602.
[2]
Filosa A, Filosa G. Neutrophilic dermatoses: a broad spectrum of disease[J]. G Ital Dermatol Venereol, 2018, 153(2): 265-272.
[3]
Castanheira FVS, Kubes P. Neutrophils and NETs in modulating acute and chronic inflammation[J]. Blood, 2019, 133(20): 2178-2185.
[4]
Ravindran M, Khan MA, Palaniyar N. Neutrophil extracellular trap formation: physiology, pathology, and pharmacology[J]. Biomolecules, 2019, 9(8): 365.
[5]
Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria[J]. Science, 2004, 303(5663): 1532-1535.
[6]
Lee KH, Kronbichler A, Park DD, et al. Neutrophil extracellular traps (NETs) in autoimmune diseases: a comprehensive review[J]. Autoimmun Rev, 2017, 16(11): 1160-1173.
[7]
Mistry P, Carmona-Rivera C, Ombrello AK, et al. Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome[J]. Ann Rheum Dis, 2018, 77(12): 1825-1833.
[8]
Wu BC, Patel ED, Ortega-Loayza AG. Drug-induced pyoderma gangrenosum: a model to understand the pathogenesis of pyoderma gangrenosum[J]. Br J Dermatol, 2017, 177(1): 72-83.
[9]
Poppensieker K, Otte DM, Schürmann B, et al. CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells[J]. Proc Natl Acad Sci U S A, 2012, 109(10): 3897-3902.
[10]
Maverakis E, Marzano AV, Le ST, et al. Pyoderma gangrenosum[J]. Nat Rev Dis Primers, 2020, 6(1): 81.
[11]
Marzano AV, Ortega-Loayza AG, Heath M, et al. Mechanisms of inflammation in neutrophil-mediated skin diseases[J]. Front Immunol, 2019, 10: 1059.
[12]
Braswell SF, Kostopoulos TC, Ortega-Loayza AG. Pathophysiology of pyoderma gangrenosum (PG): an updated review[J]. J Am Acad Dermatol, 2015, 73(4): 691-698.
[13]
Park S, Shin H, Lee DH, et al. Pyoderma gangrenosum mimicking necrotizing fasciitis on magnetic resonance imaging: a case report and literature review[J]. Am J Case Rep, 2022, 23: e931734.
[14]
George C, Deroide F, Rustin M. Pyoderma gangrenosum- a guide to diagnosis and management[J]. Clin Med (Lond), 2019, 19(3): 224-228.
[15]
Landis ET, Taheri A, Jorizzo JL. Gulliver′s sign: a recognizable transition from inflammatory to healing stages of pyoderma gangrenosum[J]. J Dermatolog Treat, 2015, 26(2): 171-172.
[16]
Jimenez-Cauhe J, Fonda-Pascual P. Visual dermatology: gulliver sign: when pyoderma gangrenosum soothes[J]. Journal of Cutaneous Medicine and Surgery, 2020, 24(4): 408.
[17]
李瑾,杨道秋,翟志芳,等. 坏疽性脓皮病28例临床分析[J]. 临床皮肤科杂志2017, 46(4): 230-233.
[18]
冯尘尘,杨转花,李高洁,等. 坏疽性脓皮病诊疗研究进展[J]. 中国麻风皮肤病杂志2022, 38(6): 414-418.
[19]
黎晓丽,林乃余,唐旭华,等. 坏疽性脓皮病发病机制的研究进展[J]. 皮肤性病诊疗学杂志2022, 29(2): 178-181.
[20]
Cugno M, Borghi A, Marzano AV. PAPA, PASH and PAPASH syndromes: pathophysiology, presentation and treatment[J]. Am J Clin Dermatol, 2017, 18(4): 555-562.
[21]
Garcovich S, Genovese G, Moltrasio C, et al. PASH, PAPASH, PsAPASH, and PASS: the autoinflammatory syndromes of hidradenitis suppurativa[J]. Clin Dermatol, 2021, 39(2): 240-247.
[22]
杨岚,杨青文,付妍婕. 坏疽性脓皮病发病机制与诊断的研究进展[J]. 中华烧伤与创面修复杂志2022, 38(6): 569-573.
[23]
Su WPD, Davis MDP, Weenig RH, et al. Pyoderma gangrenosum: clinicopathologic correlation and proposed diagnostic criteria[J]. Int J Dermatol, 2004, 43(11): 790-800.
[24]
杨海琼,彭琳琳,景东云,等. 误诊为坏疽性脓皮病的皮肤播散型孢子丝菌病1例[J]. 中国皮肤性病学杂志2020, 34(1): 107-110.
[25]
冀斐,孟昭影. 坏疽性脓皮病2例并文献复习[J]. 中国中西医结合皮肤性病学杂志2022, 21(6): 542-545.
[26]
杨枫,陈怡雯,侯麦花. 人工皮炎误诊为坏疽性脓皮病1例[J]. 中国皮肤性病学杂志2018, 32(12): 1469-1471.
[27]
Wang JY, French LE, Shear NH, et al. Drug-induced pyoderma gangrenosum: a review[J]. Am J Clin Dermatol, 2018, 19(1): 67-77.
[28]
郑飞跃,吴燕,饶跃峰,等. 诺氏评估量表在药物不良反应评价中的作用及实例分析[J]. 中国药学杂志2012, 47(8): 650-652.
[29]
Ahn C, Negus D, Huang W. Pyoderma gangrenosum: a review of pathogenesis and treatment[J]. Expert Rev Clin Immunol, 2018, 14(3): 225-233.
[30]
曾琳茜,姚越,黄欣,等. 生物制剂在坏疽性脓皮病治疗中的研究进展[J/OL]. 中国皮肤性病学杂志( 2022-03-17 )[2023-07-15].
[31]
吴新果,黄茜,周小勇. 糖皮质激素联合环孢素A治疗溃疡型坏疽性脓皮病1例[J]. 中国皮肤性病学杂志2015, 29(11): 1203, 1207.
[32]
陈红清. 嗜中性皮病的诊治进展[J]. 中国皮肤性病学杂志2018, 32(10): 1213-1216.
[33]
Kolios AGA, Maul JT, Meier B, et al. Canakinumab in adults with steroid-refractory pyoderma gangrenosum[J]. Br J Dermatol, 2015, 173(5): 1216-1223.
[34]
Millet A, Pescarmona R, Belot A, et al. Quantification of canakinumab in human plasma by liquid chromatography-high resolution mass spectrometry[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2022, 1211: 123475.
[35]
Burgdorf B, Schlott S, Ivanov IH, et al. Successful treatment of a refractory pyoderma gangrenosum with risankizumab[J]. Int Wound J, 2020, 17(4): 1086-1088.
[36]
Strunck JL, Cutler B, Latour E, et al. Wound care dressings for pyoderma gangrenosum[J]. J Am Acad Dermatol, 2022, 86(2): 458-460.
[37]
Chen B, Li W, Qu B. Practical aspects of the diagnosis and management of pyoderma gangrenosum[J]. Front Med (Lausanne), 2023, 10: 1134939.
[38]
Hao Y, He J, Zhao Z, et al. Clinical efficacy of flap transplantation combined with vacuum sealing drainage and methylprednisolone and cyclosporine in the treatment of pyoderma gangrenosum[J]. Int Wound J, 2023, 20(5): 1491-1497.
[39]
Goldust M, Hagstrom EL, Rathod D, et al. Diagnosis and novel clinical treatment strategies for pyoderma gangrenosum[J]. Expert Rev Clin Pharmacol, 2020, 13(2): 157-161.
[40]
Xia FD, Liu K, Lockwood S, et al. Risk of developing pyoderma gangrenosum after procedures in patients with a known history of pyoderma gangrenosum-A retrospective analysis[J]. J Am Acad Dermatol, 2018, 78(2): 310-314.
[1] 衣晓丽, 胡沙沙, 张彦. HER-2低表达对乳腺癌新辅助治疗疗效及预后的影响[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 340-346.
[2] 谭巧, 苏小涵, 侯令密, 黎君彦, 邓世山. 乳腺髓样癌的诊治进展[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 366-368.
[3] 张伟. 牙及牙槽外科:舒适治疗的先锋[J]. 中华口腔医学研究杂志(电子版), 2023, 17(06): 386-388.
[4] 王得晨, 杨康, 杨自杰, 归明彬, 屈莲平, 张小凤, 高峰. 结直肠癌微卫星稳定状态和程序性死亡、吲哚胺2,3-双加氧酶关系的研究进展[J]. 中华普通外科学文献(电子版), 2023, 17(06): 462-465.
[5] 叶晓琳, 刘云飞, 庞明泉, 王海久, 任利, 侯立朝, 于文昊, 王志鑫, 樊海宁. 肝再生细胞来源及调控机制的研究进展[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 96-99.
[6] 彭旭, 邵永孚, 李铎, 邹瑞, 邢贞明. 结肠肝曲癌的诊断和外科治疗[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 108-110.
[7] 马伟强, 马斌林, 吴中语, 张莹. microRNA在三阴性乳腺癌进展中发挥的作用[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 111-114.
[8] 张海涛, 康婵娟, 翟静洁. 胰管支架置入治疗急性胆源性胰腺炎效果观察[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 654-657.
[9] 杨雪, 张伟, 尚培中, 宋创业, 尚丹丹, 张蔚. 胆囊十二指肠瘘结石经瘘口排出后自愈一例报道[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 707-708.
[10] 孔博, 张璟, 吕珂. 超声技术在复杂腹壁疝诊治中的作用[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(06): 670-673.
[11] 姜明, 罗锐, 龙成超. 闭孔疝的诊断与治疗:10年73例患者诊疗经验总结[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(06): 706-710.
[12] 陆志峰, 周佳佳, 梁舒. 虚拟现实技术在治疗弱视中的临床应用研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(08): 891-895.
[13] 李田, 徐洪, 刘和亮. 尘肺病的相关研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(08): 900-905.
[14] 岳瑞雪, 孔令欣, 郝鑫, 杨进强, 韩猛, 崔国忠, 王建军, 张志生, 孔凡庭, 张维, 何文博, 李现桥, 周新平, 徐东宏, 胡崇珠. 乳腺癌HER2蛋白表达水平预测新辅助治疗疗效的真实世界研究[J]. 中华临床医师杂志(电子版), 2023, 17(07): 765-770.
[15] 符梅沙, 周玉华, 李慧, 薛春颜. 淋巴细胞免疫治疗对复发性流产患者外周血T淋巴细胞亚群分布与PD1/PD-L1表达的影响及意义[J]. 中华临床医师杂志(电子版), 2023, 17(06): 726-730.
阅读次数
全文


摘要