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中华损伤与修复杂志(电子版) ›› 2026, Vol. 21 ›› Issue (04) : 315 -319. doi: 10.3877/cma.j.issn.1673-9450.2026.04.013

综述

磷脂酰肌醇-3激酶/蛋白激酶B信号通路在骨骼肌损伤修复中的研究进展
李亚春1, 李满2,()   
  1. 1 030000 太原,山西医科大学第二临床医学院
    2 030000 太原,山西医科大学第二医院神经内科
  • 收稿日期:2026-02-26 出版日期:2026-08-01
  • 通信作者: 李满
  • 基金资助:
    山西省自然科学研究面上项目(202203021211038)

Research progress of the phosphoinositide 3-kinase/protein kinase B signaling pathway in the repair of skeletal muscle injury

Yachun Li1, Man Li2,()   

  1. 1 The Second Clinical Medical College of Shanxi Medical University,Taiyuan 030000, China
    2 Department of Neurology,the Second Hospital of Shanxi Medical University,Taiyuan 030000,China
  • Received:2026-02-26 Published:2026-08-01
  • Corresponding author: Man Li
引用本文:

李亚春, 李满. 磷脂酰肌醇-3激酶/蛋白激酶B信号通路在骨骼肌损伤修复中的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2026, 21(04): 315-319.

Yachun Li, Man Li. Research progress of the phosphoinositide 3-kinase/protein kinase B signaling pathway in the repair of skeletal muscle injury[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2026, 21(04): 315-319.

骨骼肌损伤修复是涉及细胞增殖、分化及组织重建的复杂生物过程,其调控机制多样且相互关联。磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)信号通路作为细胞增殖、存活和代谢的核心信号通路之一,在骨骼肌损伤修复中发挥重要作用,尤其在肌卫星细胞激活和成肌细胞分化过程中尤为关键。然而,该通路在骨骼肌损伤修复中的具体分子机制仍需进一步阐明。该文对PI3K/Akt信号通路在骨骼肌损伤修复中的研究进展进行综述,以期为后续研究提供参考。

Skeletal muscle injury repair is a complex biological process involving cell proliferation,differentiation,and tissue reconstruction,with diverse and interrelated regulatory mechanisms. The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway as one of the core signaling pathway regulating cell proliferation,survival,and metabolism,plays an important role in skeletal muscle injury repair,and is particularly critical in the activation of muscle satellite cells and the differentiation of myoblasts. However,the specific molecular mechanisms of this pathway in skeletal muscle injury repair still need to be further elucidated. This article reviews the research progress of the PI3K/Akt signaling pathway in the repair of skeletal muscle injury aiming to provide a reference for future studies.

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