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中华损伤与修复杂志(电子版)

中华损伤与修复杂志(电子版) ›› 2016, Vol. 11 ›› Issue (03) : 186 -190. doi: 10.3877/cma.j.issn.1673-9450.2016.03.007

所属专题： 文献；

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表皮细胞迁移与创面愈合
郭小伟1, 张家平2, 黄跃生2,†()   
  1. 1. 121001　锦州，解放军第二〇五医院烧伤整形科
    2. 400038　重庆，第三军医大学西南医院烧伤研究所，创伤、烧伤与复合伤国家重点实验室
  • 收稿日期:2016-01-25 出版日期:2016-06-01
  • 通信作者: 黄跃生
  • 基金资助:
    国家重点基础研究发展计划(2012CB518101)

Epidermal cells migration and wound healing

Xiaowei Guo1, Jiaping Zhang2, Yuesheng Huang2,†()   

  1. 1. Department of Burns and Plastic Surgery, the 205th Hospital of People′s Liberation Army, Jinzhou 121001, China
    2. State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, Southwest Hospital, the Third Military Medical University, Chongqing 400038, China
  • Received:2016-01-25 Published:2016-06-01
  • Corresponding author: Yuesheng Huang
  • About author:
    Corresponding author: Huang Yuesheng, Email:
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郭小伟, 张家平, 黄跃生. 表皮细胞迁移与创面愈合[J]. 中华损伤与修复杂志(电子版), 2016, 11(03): 186-190.

Xiaowei Guo, Jiaping Zhang, Yuesheng Huang. Epidermal cells migration and wound healing[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2016, 11(03): 186-190.

创面愈合是动态的、严格有序的生物学过程，再上皮化在其中起着非常重要的作用。皮肤创面的再上皮化主要依赖于表皮细胞从创缘向创面中心的迁移。创面形成后由于局部血液循环障碍和创周细胞氧耗的增加，导致创面形成低氧的微环境，低氧已经被证明能够促进表皮细胞迁移和创面愈合。创面形成后由于跨上皮电势差的消失产生内源性的直流电场，此电场是创面愈合过程中指导表皮细胞向创面中心迁移的最重要的方向信号。此外，创面形成后产生的炎症因子一氧化氮被证实也能够促进表皮细胞迁移和创面愈合。综上所述，低氧、电场和一氧化氮可通过促进表皮细胞向创面中心迁移进而加快创面愈合过程。

关键词: 细胞运动, 创伤和损伤, 伤口愈合, 一氧化氮, 低氧, 电场

Wound healing is a dynamic and well-ordered biological process, in which re-epithelialization plays an important role. Re-epithelialization of skin wounds depends upon epidermal cells migration from the wound edge. Hypoxia is a microenvironmental stress that occurs immediately after injury, likely due to the vascular disruption and increased oxygen consumption by cells surrounding the wound edge, which has been shown to promote epidermal cells migration and wound healing. Endogenous electric field (EF) is generated instantaneously after injury due to the collapse of the trans-epithelial potentials, which plays an overriding guidance role in directing epidermal cells migration towards the wound center in wound healing. In addition, nitric monoxide (NO) as an inflammatory factor produced after wounds occur has been found to promote epidermal cells migration and wound healing. In conclusion, hypoxia, EF and NO accelerate the healing process though promoting epidermal cells migration towards the wound center.

Key words: Cell movement, Wounds and injuries, Wound healing, Nitric oxide, Hypoxia, Electric field
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