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中华损伤与修复杂志(电子版) ›› 2020, Vol. 15 ›› Issue (04) : 316 -321. doi: 10.3877/cma.j.issn.1673-9450.2020.04.017

所属专题: 文献

综述

脓毒症生物标志物研究进展
张杰1, 章雄1, 刘琰1,()   
  1. 1. 200025 上海交通大学医学院附属瑞金医院灼伤整形科
  • 收稿日期:2020-06-14 出版日期:2020-08-01
  • 通信作者: 刘琰
  • 基金资助:
    国家自然科学基金面上项目(81871564); 上海市科技委员会自然科学基金(18ZR1423800); 上海市综合医院中西医结合专项建设项目(ZHYY-ZXYJ-HZX-201911)

Progress in research on biomarkers of sepsis

Jie Zhang1, Xiong Zhang1, Yan Liu1,()   

  1. 1. Department of Burns and Plastic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Received:2020-06-14 Published:2020-08-01
  • Corresponding author: Yan Liu
  • About author:
    Corresponding author: Liu Yan, Email:
引用本文:

张杰, 章雄, 刘琰. 脓毒症生物标志物研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2020, 15(04): 316-321.

Jie Zhang, Xiong Zhang, Yan Liu. Progress in research on biomarkers of sepsis[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2020, 15(04): 316-321.

脓毒症是导致住院患者病死的主要原因之一,脓毒症的早期诊断及治疗对于降低患者病死率至关重要。脓毒症生物标志物是在机体对感染的应答过程中产生的,理想的脓毒症生物学标志物应该具有高灵敏度、高特异度、低成本、便于检测及可重复性好等特征,可用于脓毒症早期诊断、危险分层、预后判断及治疗反应监测等。脓毒症生物标志物层出不穷,但缺乏有效、统一的评价方法,可用于脓毒症诊断的具高灵敏度、高特异度的生物学标志物仍然缺乏。本文根据脓毒症的病理生理特性将脓毒症相关生物标志物进行分类梳理。目前诊断脓毒症的"金标准"生物学指标并不存在,任何单一的生物标志物的诊断价值都有限,多种生物学标志物联合应用可提高脓毒症诊断的灵敏度和特异度,提高对脓毒症预后判断的准确性。

Sepsis is one of the most common causes of death in hospitalized patients, early diagnosis and treatment of sepsis is essential to reduce mortality. Sepsis biomarkers are generated during the body′s response to infection. The ideal biomarkers of sepsis should have the characteristics of high sensitivity, high specificity, low cost, easy detection and good repeatability, which can be used for early diagnosis, risk stratification, prognosis and treatment response monitoring. Biomarkers of sepsis are emerging one after another, but there is no effective and unified evaluation method. Highly sensitive and specific biomarkers that can be used for the diagnosis of sepsis are still lacking. In this paper, sepsis-related biomarkers are sorted according to the pathophysiological characteristics of sepsis. At present, the " gold standard" biological indicators for the diagnosis of sepsis do not exist. The diagnostic value of any single biomarker is limited. The combination of multiple biomarkers can improve the sensitivity and specificity of diagnosis and improve the accuracy of prognosis of sepsis.

表1 脓毒症多种生物标志物的联合应用
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