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中华损伤与修复杂志(电子版) ›› 2025, Vol. 20 ›› Issue (06) : 510 -518. doi: 10.3877/cma.j.issn.1673-9450.2025.06.008

论著

基于CiteSpace的增生性瘢痕研究热点及发展趋势的可视化分析
王江坤1,2, 唐棣1,2, 邱伟明1,2, 王淞1,2,()   
  1. 1 430062 武汉科技大学医学院
    2 430060 武汉,中部战区总医院烧伤整形科
  • 收稿日期:2025-06-05 出版日期:2025-12-01
  • 通信作者: 王淞
  • 基金资助:
    国家自然科学基金青年科学基金(82102340)

Visualization analysis of research hotspots and development trends in hypertrophic scars based on CiteSpace

Jiangkun Wang1,2, Di Tang1,2, Weiming Qiu1,2, Song Wang1,2,()   

  1. 1 Medical College,Wuhan University of Science and Technology,Wuhan 430062,China
    2 Department of Burn and Plastic Surgery,General Hospital of Central Theater Command,Wuhan 430060,China
  • Received:2025-06-05 Published:2025-12-01
  • Corresponding author: Song Wang
引用本文:

王江坤, 唐棣, 邱伟明, 王淞. 基于CiteSpace的增生性瘢痕研究热点及发展趋势的可视化分析[J/OL]. 中华损伤与修复杂志(电子版), 2025, 20(06): 510-518.

Jiangkun Wang, Di Tang, Weiming Qiu, Song Wang. Visualization analysis of research hotspots and development trends in hypertrophic scars based on CiteSpace[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2025, 20(06): 510-518.

目的

对增生性瘢痕(HS)相关中英文文献进行基于CiteSpace的可视化分析,探讨该领域研究现状、热点及未来发展趋势。

方法

检索2014年1月至2024年12月中国知网和Web of Science数据库核心合集收录的HS相关文献,采用CiteSpace 6.4.R1软件对中英文文献的发文量、作者、机构、关键词及被引频次进行可视化分析。

结果

共纳入中文文献1 358篇,英文文献3 330篇。中文文献发文量排名前3位作者分别为陶凯(26篇)、郭冰玉(14篇)和谭军(12篇),英文文献发文量排名前3位作者分别为Ogawa R(39篇)、Hu DH(37篇)和Li Y(25篇),其中2位来自中国。国内外共有632家(其中国内338家)机构发表了HS相关论文,在中文期刊上发文量最多的机构为上海交通大学医学院附属第九人民医院(38篇),在英文期刊上发文量最多的机构为上海交通大学(153篇)。共纳入295个中文关键词和547个英文关键词进行共现分析。中文关键词出现频次排名前5位依次为瘢痕疙瘩、曲安奈德、烧伤、增殖和疗效,英文关键词出现频次排名前5位依次为expression、keloids、management、skin和wound healing。中文文献关键词分析得到8个聚类,最大的聚类为烧伤;英文文献关键词分析得到7个聚类,最大的聚类为systematic review。中文文献中突现强度最高的关键词为组织构建,近年突现的关键词有迁移、儿童、安全性、血管生成、外泌体。英文文献中突现强度最高的关键词为drug delivery,近年突现的关键词有fractional CO2 laser、systematic review、pain、drug delivery、nanoparticles、dressings、safety。

结论

HS研究呈现国际化与多学科交叉特征,但国内外研究重点存在明显差异,国内研究侧重临床应用,而国际研究更关注基础科学与技术转化。未来研究趋势将集中于分子机制解析及新兴治疗技术整合。

Objective

To conduct a CiteSpace-based visualization analysis of Chinese and English literature regarding hypertrophic scars (HS), explore current research status, hotspots, and future development trends in this field.

Methods

HS-related articles published between January 2014 and December 2024 were retrieved from the China National Knowledge Infrastructure and Web of Science core collection databases. CiteSpace 6.4.R1 software was utilized to perform visualization analysis of the number of published articles, authors, institutions, keywords, and citation frequencies.

Results

A total of 1 358 Chinese publications and 3 330 English publications were included. The top three most prolific authors in Chinese publications were Tao Kai (26 articles), Guo Bingyu (14 articles), and Tan Jun (12 articles). For English publications, the top three most prolific authors were Ogawa R (39 articles), Hu DH (37 articles), and Li Y (25 articles), with two of them affiliated with Chinese institutions. A total of 632 institutions contributed to publications on HS. Among the 338 institutions in Chinese dataset, the Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine published the most articles (38 articles). Among the 294 institutions in English dataset, Shanghai Jiao Tong University ranked highest with 153 articles. A total of 295 Chinese keywords and 547 English keywords were included in co-occurrence analysis.  The top five keywords in frequency in Chinese literature were keloid, triamcinolone acetonide, burn, proliferation, and efficacy. The top five keywords in frequency in English literature were expression, keloids, management, skin, and wound healing. Keyword clustering analysis revealed eight clusters in Chinese literature, with burn being the largest, and seven clusters in English literature, with systematic review being the largest. In Chinese literature, the keyword with the highest emergent strength was tissue engineering, while recent emerging keywords included migration, children, safety, angiogenesis, and exosomes. In English literature, the keyword with the highest emergent strength was drug delivery, while recent emerging keywords included fractional CO2 laser, systematic review, pain, drug delivery, nanoparticles, dressings, and safety.

Conclusion

Research on HS exhibits increasing globalization and interdisciplinary integration. However, distinct differences exist between domestic and international research patterns, domestic research focuses more on clinical applications, while international studies emphasize basic science and translational technology. The future research will likely focus on elucidating molecular mechanisms and integrating emerging therapeutic technologies.

图1 2014—2024年中国知网和Web of Science数据库核心合集中增生性瘢痕领域年发文量
表1 2014—2024年中国知网和Web of Science数据库核心合集中增生性瘢痕领域发文量排名前10位的作者
图2 2014—2024年中国知网和Web of Science数据库核心合集中增生性瘢痕领域的作者合作网络图谱。A示中国知网数据库中增生性瘢痕领域的作者合作网络图谱;B示Web of Science数据库核心合集中增生性瘢痕领域的作者合作网络图谱 注:图中节点代表作者,节点越大代表作者发文量越多;节点间的连线代表发文作者之间的合作关系,连线越多,该作者与其他作者联系越紧密;颜色代表年份
表2 2014—2024年中国知网和Web of Science数据库核心合集中增生性瘢痕领域发文量排名前10位的机构
图3 2014—2024年中国知网和Web of Science数据库核心合集中增生性瘢痕领域的关键词共现网络图谱。A示中国知网数据库中增生性瘢痕领域的关键词共现网络图谱;B示Web of Science数据库核心合集中增生性瘢痕领域的关键词共现网络图谱 注:图中每个节点代表1个关键词,节点越大代表该关键词出现频次越多;节点间的连线代表关键词之间的共现关系;节点颜色代表年份;expression为表达,keloids为瘢痕疙瘩,management为管理,skin为皮肤,wound healing为创面愈合,outcome为结果,burn injury为烧伤,wound repair为创面修复,risk为风险,epidemiology为流行病学
表3 2014—2024年中国知网和Web of Science数据库核心合集中增生性瘢痕领域出现频次排名前10位的关键词
表4 2014—2024年中国知网和Web of Science数据库核心合集中增生性瘢痕领域中心性排名前10位的关键词
图4 2014—2024年中国知网和Web of Science数据库核心合集中增生性瘢痕领域的关键词聚类图谱。A示中国知网数据库中增生性瘢痕领域的关键词聚类图谱;B示Web of Science数据库核心合集中增生性瘢痕领域的关键词聚类图谱 注:图中节点大小代表文献数量,节点间连线代表节点间的关联强度;systematic review为系统综述,keloid fibroblast为瘢痕疙瘩成纤维细胞,hypertrophic cardiomyopathy为肥厚性心肌病,therapeutic effect为治疗效果,wound healing为创面愈合,vancouver scar scale为温哥华瘢痕量表,hypertrophic scar therapy为增生性瘢痕治疗
图5 2014—2024年中国知网和Web of Science数据库核心合集中增生性瘢痕领域的关键词突现图谱。A示中国知网数据库中增生性瘢痕领域的关键词突现图谱;B示Web of Science数据库核心合集中增生性瘢痕领域的关键词突现图谱 注:近年突现的英文关键词中fractional CO2 laser为点阵二氧化碳激光,systematic review为系统综述,pain为疼痛,drug delivery为药物递送,nanoparticles为纳米颗粒,dressings为敷料,safety为安全性
图6 2014—2024年Web of Science数据库核心合集中增生性瘢痕领域的文献共被引图谱 注:2篇或多篇文献同时被1篇及以上文献引用,则这2篇或多篇文献构成共被引关系;括号中为文献发表年份,网络中的连线代表文献之间的共引关系,节点越大代表该文献被引用得越多,即为该领域的重要文献
表5 2014—2024年Web of Science 数据库核心合集中增生性瘢痕领域总被引频次排名前10位的文献
[1]
Fan YGuo XTian Y, et al. Botulinum toxin type A inhibits the formation of hypertrophic scar through the JAK2/STAT3 pathway[J]. Biomol Biomed202425(1): 249-258.
[2]
Wu JSong YWang J, et al. Isorhamnetin inhibits hypertrophic scar formation through TGF-β1/Smad and TGF-β1/CREB3L1 signaling pathways[J]. Heliyon202410(13): e33802.
[3]
Zhong YZhang YLu B, et al. Hydrogel loaded with components for therapeutic applications in hypertrophic scars and keloids[J]. Int J Nanomedicine202419: 883-899.
[4]
Xiao SQi JLi J, et al. Mechanical micronization of lipoaspirates combined with fractional CO2 laser for the treatment of hypertrophic scars[J]. Plast Reconstr Surg2023151(3): 549-559.
[5]
Yu JMao ZZhou Z, et al. Microbiome dysbiosis occurred in hypertrophic scars is dominated by S. aureus colonization[J]. Front Immunol202314: 1227024.
[6]
Vorstandlechner VCopic DKlas K, et al. The secretome of irradiated peripheral mononuclear cells attenuates hypertrophic skin scarring[J]. Pharmaceutics202315(4): 1065.
[7]
Li XHe MHe H. Treatment of wound healing with sequential therapy to accelerate recovery and inhibit scar hyperplasia: a case report[J]. Clin Cosmet Investig Dermatol202114: 821-825.
[8]
Meetam TAngspatt AAramwit P. Evidence of potential natural products for the management of hypertrophic scars[J]. J Evid Based Integr Med202429: 2515690X241271948.
[9]
Pradhan MPethe P. The molecular mechanisms involved in the hypertrophic scars post-burn injury[J]. Yale J Biol Med202396(4): 549-563.
[10]
Yang ZRSuo HFan JW, et al. Endogenous stimuli-responsive separating microneedles to inhibit hypertrophic scar through remodeling the pathological microenvironment[J]. Nat Commun202415(1): 2038.
[11]
Gong XZhao QZhang H, et al. The effects of mesenchymal stem cells-derived exosomes on metabolic reprogramming in scar formation and wound healing[J]. Int J Nanomedicine202419: 9871-9887.
[12]
Chen ZGao JLi L. New challenges in scar therapy: the novel scar therapy strategies based on nanotechnology[J].  Nanomedicine (Lond)202419(28): 2413-2432.
[13]
Shen JWei SGuo J, et al. Evolutionary trend analysis of the pharmaceutical management research field from the perspective of mapping the knowledge domain[J]. Front Health Serv20244: 1384364.
[14]
Wang LYu TWang R, et al. A bibliometric analysis of optic atrophy from 2003 to 2023: research trends and hot spots[J]. Front Med (Lausanne)202411: 1497446.
[15]
Wang GZou XWeng J, et al. Bibliometric analysis reveals the research hotspots and trends of nasopharyngeal carcinoma immunotherapy[J]. Hum Vaccin Immunother202420(1): 2360341.
[16]
Feng YLv MZeng S, et al. Knowledge domains and emerging trends in radiotherapy in oesophageal cancer from 2004 to 2023: a bibliometric analysis and visualization study[J]. J Radiat Res202465(4): 433-449.
[17]
Zhu XPeng X. Strategic assessment model of smart stadiums based on genetic algorithms and literature visualization analysis: a case study from Chengdu, China[J]. Heliyon202410(11): e31759.
[18]
Zhao YAi WZheng J, et al. A bibliometric and visual analysis of epigenetic research publications for Alzheimer's disease (2013-2023)[J]. Front Aging Neurosci202416: 1332845.
[19]
Yang CLiu HFeng X, et al. Research hotspots and frontiers of neoadjuvant therapy in triple-negative breast cancer: a bibliometric analysis of publications between 2002 and 2023[J]. Int J Surg2024110(8): 4976-4992.
[20]
Liu ZZhang ZXie P. Global research trends in endometrial receptivity from 2000 to 2024: bibliometric analysis[J]. Front Med (Lausanne)202411: 1465893.
[21]
Yuan YWang Q. Characteristics, hotspots, and prospects of short video research: a review of papers published in China from 2012 to 2022[J]. Heliyon202410(3): e24885.
[22]
Berman BMaderal ARaphael B. Keloids and hypertrophic scars: pathophysiology, classification, and treatment[J]. Dermatol Surg201743(Suppl 1):S3-S18.
[23]
Ogawa R. Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis[J]. Int J Mol Sci201718(3): 606.
[24]
Lee HJJang YJ. Recent understandings of biology, prophylaxis and treatment strategies for hypertrophic scars and keloids[J]. Int J Mol Sci201819(3): 711.
[25]
Song WPBo XWDou HX, et al. Association between periodontal disease and coronary heart disease: a bibliometric analysis[J]. Heliyon202410(7): e28325.
[26]
Sun WHuang PSong H, et al. Bibliometric analysis of acute pancreatitis in Web of Science database based on CiteSpace software[J]. Medicine (Baltimore)202099(49): e23208.
[27]
Chai JZhang NLi T, et al. Cutting-edge and topical issues in the treatment of breast cancer with traditional Chinese medicine based on CiteSpace bibliometric analysis[J]. Medicine (Baltimore)2024103(49): e40784.
[28]
Wang JCao BLin S, et al. A bibliometric analysis of urologic chronic pelvic pain syndrome from 2000 to 2022[J]. J Pain Res202316: 1225-1241.
[29]
陈鑫格,梁蓉,何秋月,等. 重组牛碱性成纤维细胞生长因子联合曲安奈德治疗增生性瘢痕的临床研究[J]. 中华保健医学杂志202527(1): 146-150.
[30]
黎景波,曹海燕,梁玲毓,等. 支具面罩治疗面部增生性瘢痕疗效的短期研究[J]. 中国康复医学杂志202439(10): 1456-1461.
[31]
古敏仪,纪世召. 激光治疗在烧伤后瘢痕修复中的研究进展[J]. 海军军医大学学报2025: 1-8.
[32]
Zivari-Ghader THamishehkar HShokouhi B, et al. Chitosan-alginate hydrogel enriched with hypericum perforatum callus extract for improved wound healing and scar inhibition[J]. ACS Appl Mater Interfaces202416(49): 67344-67361.
[33]
Sufianov ABeilerli AKudriashov V, et al. Advances in transdermal siRNAs delivery: a review of current research progress[J]. Non-coding RNA Research20238(3): 392-400.
[34]
Bi SChai LYuan X, et al. MicroRNA-98 inhibits the cell proliferation of human hypertrophic scar fibroblasts via targeting Col1A1[J]. Biol Res201750(1): 22.
[35]
Chen YWei WLi X. Clinical efficacy of CO2 fractional laser in treating post-burn hypertrophic scars in children: a meta-analysis[J]. Skin Res Technol202430(2): e13605.
[36]
陶瑞,谭植襄,李思成,等. 外泌体在增生性瘢痕和瘢痕疙瘩治疗中的研究进展[J]. 临床外科杂志202230(12): 1196-1199.
[37]
Gauglitz GGKorting HCPavicic T, et al. Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies[J]. Mol Med201117(1-2): 113-125.
[38]
Zhao SLiu HWang H, et al. Inhibition of phosphatidylinositol 3-kinase catalytic subunit alpha by miR-203a-3p reduces hypertrophic scar formation via phosphatidylinositol 3-kinase/AKT/mTOR signaling pathway[J]. Burns Trauma202412: tkad048.
[39]
Haykal DWill FCartier H, et al. Epigenetic modifications and the role of medical lasers in enhancing skin regeneration[J]. J Cosmet Dermatol202524(1): e16780.
[40]
Liu PHu ZHuang S, et al. Application of 3D printed models of complex hypertrophic scars for preoperative evaluation and surgical planning[J]. Front Bioeng Biotechnol20208: 115.
[41]
Wang XSWei PYHu CW, et al. 3D printing of Rg3-loaded hydrogel scaffolds: anti-inflammatory and scar-formation related collagen inhibitory effects for scar-free wound healing[J]. J Mater Chem B202412(19): 4673-4685.
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