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中华损伤与修复杂志(电子版) ›› 2025, Vol. 20 ›› Issue (03) : 248 -253. doi: 10.3877/cma.j.issn.1673-9450.2025.03.010

综述

光动力治疗在创面修复中应用的研究进展
李文池1, 沈拓2,()   
  1. 1. 330000 南昌大学第一附属医院烧伤整形与创面修复医学中心
    2. 200120 上海,同济大学附属东方医院重症医学科
  • 收稿日期:2025-03-16 出版日期:2025-06-01
  • 通信作者: 沈拓

A review of the application of photodynamic therapy in wound healing

Wenchi Li1, Tuo Shen2,()   

  1. 1. Medical Center of Burn Plastic Surgery and Wound Repair,the First Affiliated Hospital,Nanchang University,Nanchang 330000,China
    2. Department of Critical Care Medicine,Shanghai East Hospital Affiliated to Tongji University,Shanghai 200120,China
  • Received:2025-03-16 Published:2025-06-01
  • Corresponding author: Tuo Shen
引用本文:

李文池, 沈拓. 光动力治疗在创面修复中应用的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2025, 20(03): 248-253.

Wenchi Li, Tuo Shen. A review of the application of photodynamic therapy in wound healing[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2025, 20(03): 248-253.

抗生素滥用等多种因素可能导致创面治疗失败,开发创新且有效的治疗方式对于降低感染相关病死率和改善患者预后具有重要意义。光动力治疗(PDT)是一种新型的创面修复方法,通过使用光敏剂并结合特定光源照射组织,产生自由基或活性氧,从而诱导细胞死亡。PDT能够通过多种机制促进伤口愈合,包括杀灭细菌、减轻炎症、刺激成纤维细胞增殖以及提高转化生长因子(TGF-β)水平。基于这些作用机制,PDT在促进创面愈合和组织重塑方面展现出良好的效果。该文主要总结了光动力治疗的基本构成及其在烧伤创面、糖尿病性溃疡、压力性溃疡、瘢痕创面及其他创面中的临床应用。

The abuse of antibiotics and other factors may lead to the failure of wound treatment.Developing innovative and effective therapeutic approaches is of great significance for reducing infectionrelated mortality and improving patient outcomes.Photodynamic therapy (PDT) is a novel method for wound repair, which utilizes photosensitizers combined with specific light sources to irradiate tissues, generating free radicals or reactive oxygen species that induce cell death.PDT promotes wound healing through multiple mechanisms, including killing bacteria, alleviating inflammation, stimulating fibroblast proliferation, and increasing transforming growth factor (TGF-β) levels.Based on these mechanisms, PDT demonstrates promising efficacy in promoting wound healing and tissue remodeling.This article primarily summarizes the basic components of photodynamic therapy and its clinical applications in burn wounds, diabetic ulcers,pressure ulcers, scar wounds, and other types of wounds.

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