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中华损伤与修复杂志(电子版) ›› 2026, Vol. 21 ›› Issue (02) : 141 -146. doi: 10.3877/cma.j.issn.1673-9450.2026.02.011

综述

富血小板血浆通过调控巨噬细胞极化促进创面愈合的研究进展
郑文浩1,2, 王海霞3, 程飚1,2,()   
  1. 1 510080 广州,广东药科大学第一临床医学院
    2 510010 广州,解放军南部战区总医院烧伤整形科
    3 116011 大连,解放军联勤保障部队第九六七医院口腔科
  • 收稿日期:2025-12-29 出版日期:2026-04-01
  • 通信作者: 程飚
  • 基金资助:
    国家自然科学基金面上项目(82172223)

Research progress on platelet-rich plasma promoting wound healing by regulating macrophage polarization

Wenhao Zheng1,2, Haixia Wang3, Biao Cheng1,2,()   

  1. 1 The First Clinical Medical School of Guangdong Pharmaceutical University,Guangzhou 510080,China
    2 Department of Burns and Plastic Surgery,General Hospital of Southern Theater Command of PLA,Guangzhou 510010,China
    3 Department of Stomatology,the 967th Hospital of the Joint Logistics Support Force of the PLA,Dalian 116011,China
  • Received:2025-12-29 Published:2026-04-01
  • Corresponding author: Biao Cheng
引用本文:

郑文浩, 王海霞, 程飚. 富血小板血浆通过调控巨噬细胞极化促进创面愈合的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2026, 21(02): 141-146.

Wenhao Zheng, Haixia Wang, Biao Cheng. Research progress on platelet-rich plasma promoting wound healing by regulating macrophage polarization[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2026, 21(02): 141-146.

创面愈合过程依赖于机体对免疫微环境的动态调控,在该过程中巨噬细胞表型的时序性转化扮演着至关重要的角色。富血小板血浆(PRP)是一种通过血液分离制备的生物制剂,富含多种活性因子,能够通过调控巨噬细胞极化改善创面愈合的最终结局。该综述总结了PRP借助血小板α颗粒、致密颗粒以及细胞外囊泡等多种分泌系统对巨噬细胞募集、代谢重编程以及表型转化的调控机制,阐述了生长因子、代谢信号以及外泌体的作用途径,展望了基于巨噬细胞精准调控的PRP优化策略及其在复杂创面修复中的应用前景。

 Wound healing depends on the dynamic regulation of the immune microenvironment, in which the sequential phenotypic transition of macrophages plays a pivotal role. Platelet-rich plasma (PRP) is a blood-derived biological product enriched with multiple bioactive molecules and has been shown to improve wound healing outcomes by modulating macrophage polarization. This review summarizes the mechanisms by which PRP regulates macrophage recruitment, metabolic reprogramming, and phenotypic transition through multiple platelet-derived secretory systems, including platelet α-granules, dense granules, and extracellular vesicles. The roles of growth factors, metabolic signaling pathways, and exosomes in these processes are also discussed. Furthermore, potential strategies for optimizing PRP based on precise macrophage regulation and their prospective applications in the repair of complex wounds are highlighted.

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