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中华损伤与修复杂志(电子版) ›› 2017, Vol. 12 ›› Issue (01) : 1 -6. doi: 10.3877/cma.j.issn.1673-9450.2017.01.001

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血小板流变行为在损伤修复过程中的作用
张庆富1()   
  1. 1. 050031 石家庄,河北医科大学第一医院烧伤整形外科
  • 收稿日期:2016-10-26 出版日期:2017-02-01
  • 通信作者: 张庆富
  • 基金资助:
    河北省重点基础研究项目(14967724D); 河北省自然科学基金(C2011206080); 河北省省级重大医学科研课题(zd2013080)

Role of platelet rheological behavior in injury repair

Qingfu Zhang1,()   

  1. 1. Department of Burns and Plastic Surgery, the First Hospital of Hebei Medical University, Shijiazhuang 050031, China
  • Received:2016-10-26 Published:2017-02-01
  • Corresponding author: Qingfu Zhang
  • About author:
    Corresponding author: Zhang Qingfu, Email:
引用本文:

张庆富. 血小板流变行为在损伤修复过程中的作用[J/OL]. 中华损伤与修复杂志(电子版), 2017, 12(01): 1-6.

Qingfu Zhang. Role of platelet rheological behavior in injury repair[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2017, 12(01): 1-6.

血小板流变行为受多种因素影响,损伤是其中的常见因素。损伤不仅引起血小板数量和形态结构改变,还引起血小板黏附、聚集、收缩及释放反应。导致微血管功能及微循环血液流变学异常,使组织和器官血液灌注减少。血小板流变行为异常可使损伤进一步加重,甚至诱发播散性血管内凝血、全身炎症反应综合征、休克、多器官功能障碍综合征、肺栓塞,危及生命。因此,探讨损伤对血小板流变行为的影响,采取改善血小板流变行为的治疗措施,对进一步认识损伤机制及提高危重症救治水平有重要意义。

Platelet rheological behavior is influenced by many factors, damage is one of the common factors. Damage not only causes the change of the number and structure of platelets, causing platelet adhesion and aggregation, contraction and release reaction. It causes abnormal in terms of microvascular function and microcirculation blood rheology and it causes the tissue and organ blood perfusion decreased. Abnormal platelet rheological behavior can further aggravate the injury, and even induce disseminated intravascular coagulation, systemic inflammatory response syndrome, shock, multiple organ dysfunction syndrome, pulmonary embolism, life-threatening. Therefore, it is of great significance for us to further understand the mechanism of injury and to improve the level of treatment of critical illness, to explore the effect of injury on platelet rheological behavior, and to improve the treatment of platelet rheological behavior.

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