切换至 "中华医学电子期刊资源库"

中华损伤与修复杂志(电子版) ›› 2018, Vol. 13 ›› Issue (06) : 469 -472. doi: 10.3877/cma.j.issn.1673-9450.2018.06.015

所属专题: 文献

综述

预处理间充质干细胞促进创面愈合的研究进展
王琼1, 刘玲英2, 巴特3,(), 周彪3   
  1. 1. 010059 呼和浩特,内蒙古医科大学;014010 包头,内蒙古医科大学第三附属医院烧伤科 内蒙古烧伤研究所
    2. 100048 北京,解放军总医院第一附属医院烧伤整形科
    3. 014010 包头,内蒙古医科大学第三附属医院烧伤科 内蒙古烧伤研究所
  • 收稿日期:2018-11-02 出版日期:2018-12-01
  • 通信作者: 巴特
  • 基金资助:
    内蒙古自治区自然科学基金项目(2015MS0815); 内蒙古医科大学科技百万工程(联合)项目计划书((YKD2016KJBW(LH)041))

Research progress of pretreated mesenchymal stem cell for wound healing

Qiong Wang1, Lingying Liu2, Te Ba3,(), Biao Zhou3   

  1. 1. Inner Mongolia Medical University, Huhhot 010059, China; Department of Burns, Inner Mongolia Burn Research Institute, Third Affiliated Hospital of Inner Mongolia Medical University, Baotou 014010, China
    2. Department of Burns and Plastic Surgery, First Affiliated Hospital of People′s Liberation Army General Hospital, Beijing 100048, China
    3. Department of Burns, Inner Mongolia Burn Research Institute, Third Affiliated Hospital of Inner Mongolia Medical University, Baotou 014010, China
  • Received:2018-11-02 Published:2018-12-01
  • Corresponding author: Te Ba
  • About author:
    Corresponding author: Ba Te, Email:
引用本文:

王琼, 刘玲英, 巴特, 周彪. 预处理间充质干细胞促进创面愈合的研究进展[J]. 中华损伤与修复杂志(电子版), 2018, 13(06): 469-472.

Qiong Wang, Lingying Liu, Te Ba, Biao Zhou. Research progress of pretreated mesenchymal stem cell for wound healing[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2018, 13(06): 469-472.

各种急、慢性创面发生率较高,给患者及医疗资源带来极大负担,干细胞疗法目前被广泛应用于临床研究,移植后能够有效修复损伤组织。但由于受到感染、缺氧、炎性因子等多种因素的影响,移植后干细胞存活率低下,无法有效归巢至损伤组织。因此,增加干细胞在体效率对促进创面修复有至关重要的作用。预处理干细胞能够改变细胞生物学活性,是提高干细胞在微环境的耐受力以及归巢能力的最佳策略。本文就预处理间充质干细胞促进创面愈合的研究进展作一综述。

The incidence of various acute and chronic wounds is high, which brings great burden to patients and medical resources. Stem cell therapy is widely used in clinical research and can effectively repair injured tissue after transplantation. The survival rate of stem cells after transplantation is low due to the influence of infection, hypoxia, inflammatory factors and other factors, so it is unable to effectively homing to the injured tissue. Therefore, increasing the efficiency of stem cells in vivo plays an important role in promoting wound repair. Pretreatment of stem cells can change the biological activity of cells, which is the best strategy to improve the tolerance and homing ability of stem cells in microenvironment. This article reviews the progress of pretreated mesenchymal stem cell in promoting wound healing.

[1]
刘玲英,柴家科,侯玉森,等. 严重烧伤患者血清对人脐带MSCs生物学特性的影响[J]. 中国修复重建外科杂志,2013, 27(7):769-774.
[2]
Won YW, Patel AN, Bull DA. Cell surface engineering to enhance mesenchymal stem cell migration toward an SDF-1 gradient[J]. Biomaterials, 2014, 35(21):5627-5635.
[3]
杨靖,柴家科,刘玲英. 间充质干细胞对烧伤创面免疫调控作用的研究进展[J/CD]. 中华损伤与修复杂志(电子版), 2014, 9(6):668-671.
[4]
Liu L, Yu Y, Hou Y, et al. Human umbilical cord mesenchymal stem cells transplantation promotes cutaneous wound healing of severe burned rats[J]. PLoS One, 2014, 9(2):e88348.
[5]
Ghosh D, McGrail DJ, Dawson MR. TGF-β1 Pretreatment Improves the Function of Mesenchymal Stem Cells in the Wound Bed[J]. Front Cell Dev Biol, 2017, 5:28.
[6]
Naderi-Meshkin H, Bahrami AR, Bidkhori HR, et al. Strategies to improve homing of mesenchymal stem cells for greater efficacy in stem cell therapy[J]. Cell Biol Int, 2015, 39(1):23-34.
[7]
Dabiri G, Heiner D, Falanga V. The emerging use of bone marrow-derived mesenchymal stem cells in the treatment of human chronic wounds[J]. Expert Opin Emerg Drugs, 2013, 18(4):405-419.
[8]
Amiri F, Jahanian-Najafabadi A, Roudkenar MH. In vitro augmentation of mesenchymal stem cells viability in stressful microenvironments : In vitro augmentation of mesenchymal stem cells viability[J]. Cell Stress Chaperones, 2015, 20(2):237-251.
[9]
Lee S, Choi E, Cha MJ, et al. Cell adhesion and long-term survival of transplanted mesenchymal stem cells: a prerequisite for cell therapy[J]. Oxid Med Cell Longev, 2015, 2015:632902.
[10]
Suzdaltseva YG, Burunova VV, Vakhrushev IV, et al. In vitro comparison of immunological properties of cultured human mesenchymal cells from various sources[J]. Bull Exp Biol Med, 2008, 145(2):228-231.
[11]
Karp JM, Leng Teo GS. Mesenchymal stem cell homing: the devil is in the details[J]. Cell Stem Cell, 2009, 4(3):206-216.
[12]
高黎. 人脐带间充质干细胞对急性肺损伤模型中的治疗作用与机制初探[D]. 重庆:重庆医科大学,2014.
[13]
Li N, Yang YJ, Qian HY, et al. Intravenous administration of atorvastatin-pretreated mesenchymal stem cells improves cardiac performance after acute myocardial infarction: role of CXCR4[J]. Am J Transl Res, 2015, 7(6):1058-1070.
[14]
高冬蕴. 间充质干细胞调控糖尿病难愈性创面代谢并促愈合的机制[D]. 广州:南方医科大学,2014.
[15]
Liu J, Hao H, Xia L, et al. Hypoxia pretreatment of bone marrow mesenchymal stem cells facilitates angiogenesis by improving the function of endothelial cells in diabetic rats with lower ischemia[J]. PLoS One, 2015, 10(5):e0126715.
[16]
Li X, Gan K, Song G, et al. VEGF gene transfected umbilical cord mesenchymal stem cells transplantation improve the lower limb vascular lesions of diabetic rats[J]. J Diabetes Complications, 2015, 29(7):872-881.
[17]
Yang Y, Jin G, Li L, et al. Enhanced osteogenic activity of mesenchymal stem cells and co-modified BMP-2 and bFGF genes[J]. Ann Transplant, 2014, 19:629-638.
[18]
Shi E, Jiang X, Wang L, et al. Intrathecal injection of hepatocyte growth factor gene-modified marrow stromal cells attenuates neurologic injury induced by transient spinal cord ischemia in rabbits[J]. Anesthesiology, 2010, 113(5):1109-1117.
[19]
Nitzsche F, Müller C, Lukomska B, et al. Concise Review: MSC Adhesion Cascade-Insights into Homing and Transendothelial Migration[J]. Stem Cells, 2017, 35(6):1446-1460.
[20]
Sordi V. Mesenchymal stem cell homing capacity[J]. Transplantation, 2009, 87(9 Suppl):S42-S45.
[21]
Schmidt A, Ladage D, Steingen C, et al. Mesenchymal stem cells transmigrate over the endothelial barrier[J]. Eur J Cell Biol, 2006, 85(11):1179-1188.
[22]
Teo GS, Ankrum JA, Martinelli R, et al. Mesenchymal stem cells transmigrate between and directly through tumor necrosisfactor-α-activated endothelial cells via both leukocyte-like and novel mechanisms[J]. Stem Cells, 2012, 30(11):2472-2486.
[23]
Schrepfer S, Deuse T, Reichenspurner H, et al. Stem cell transplantation: the lung barrier[J]. Transplant Proc, 2007, 39(2):573-576.
[24]
Fischer UM, Harting MT, Jimenez F, et al. Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect[J]. Stem Cells Dev, 2009, 18(5):683-692.
[25]
Lee DE, Ayoub N, Agrawai DK. Mesenchymal stem cells and cutaneous wound healing: novel methods to increase cell delivery and therapeutic efficacy[J]. Stem Cell Res Ther, 2016, 7:37.
[26]
Gnecchi M, Zhang Z, Ni A, et al. Paracrine mechanisms in adult stem cell signaling and therapy[J]. Circ Res, 2008, 103(11):1204-1219.
[27]
Monsel A, Zhu YG, Gudapati V, et al. Mesenchymal stem cell derived secretome and extracellular vesicles for acute lung injury and other inflammatory lung diseases[J]. Expert Opin Biol Ther, 2016, 16(7):859-871.
[28]
Ionescu L, Byrne RN, van Haaften T, et al. Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action[J]. Am J Physiol Lung Cell Mol Physiol, 2012, 303(11):L967-977.
[29]
Kim I, Lee SK, Yoon JI, et al. Fibrin glue improves the therapeutic efect of MSCs by sustaining survival and paracrine function[J]. Tissue Eng Part A, 2013, 19(21/22):2373-2381.
[30]
Yoo KH, Jang IK, Lee MW, et al. Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues[J]. Cell Immunology, 2009, 259(2):150-156.
[31]
Chen J, Crawford R, Chen C, et al. The key regulatory roles of the PI3K/Akt signaling pathway in the functionalities of mesenchymal stem cells and applications in tissue regeneration[J]. Tissue EngPart B Rev, 2013, 19(6):516-528.
[32]
Barreiro O, Sanchez-Madrid F. Molecular basis of leukocyte-endothelium interactions during the inflammatory response[J]. Rev Esp Cardiol, 2009, 62(5):552-562.
[33]
Xu X, Zhu F, Zhang M, et al. Stromal cell-derived factor-1 enhances wound healing through recruiting bone marrow-derived mesenchymal stem cells to the wound area and promoting neovascularization[J]. Cells Tissues Organs, 2013, 197(2):103-113.
[34]
Honczarenko M, Le Y, Swierkowski M, et al. Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors[J]. Stem Cells, 2006, 24(4):1030-1041.
[35]
Kitaori T, Ito H, Schwarz EM, et al. Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model[J]. Arthritis Rheum, 2009, 60(3):813-823.
[36]
Yang D, Sun S, Wang Z, et al. Stromal cell-derived factor-1 receptor CXCR4-overexpressing bone marrow mesenchymal stem cells accelerate wound healing by migrating into skin injury areas[J]. Cell Reprogram, 2013 , 15(3):206-215.
[37]
Hocking AM, Gibran NS. Mesenchymal stem cells: paracrine signaling and diferentiation during cutaneous wound repair[J]. Exp Cell Res, 2010, 316(14):2213-2219.
[38]
Kavanagh DP, Suresh S, Newsome PN, et al. Pretreatment of Mesenchymal Stem Cells Manipulates Their Vasculoprotective Potential While Not Altering Their Homing Within the Injured Gut[J]. Stem Cells, 2015, 33(9):2785-2797.
[39]
Meng Y, Shi C, Hu B, et al. External magnetic field promotes homing of magnetized stem cells following subcutaneous injection[J]. BMC Cell Bio, 2017, 18(1):24.
[40]
Tebebi PA, Kim SJ, Williams RA, et al. Improving the therapeutic efficacy of mesenchymal stromal cells to restore perfusion in critical limb ischemia through pulsed focused ultrasound[J]. Sci Rep, 2017, 7:41550.
[41]
Burks SR, Nguyen BA, Tebebi PA, et al. Pulsed focused ultrasound pretreatment improves mesenchymal stromal cell efficacy in preventing and rescuing established acute kidney injury in mice[J]. Stem Cells, 2015, 33(4):1241-1253.
[42]
Burks SR, Ziadloo A, Hancock HA, et al. Investigation of cellular and molecular responses to pulsed focused ultrasound in a mouse model[J]. PLoS One, 2011, 6(9):e24730.
[43]
Burks SR, Ziadloo A, Kim SJ, et al. Noninvasive pulsed focused ultrasound allows spatiotemporal control of targeted homing for multiple stem cell types in murine skeletal muscle and the magnitude of cell homing can be increased through repeated applications[J]. Stem Cells, 2013, 31(11):2551-2560.
[44]
Tebebi PA, Burks SR, Kim SJ, et al. Cyclooxygenase-2 or tumor necrosis factor-α inhibitors attenuate the mechanotransductive effects of pulsed focused ultrasound to suppress mesenchymal stromal cell homing to healthy and dystrophic muscle[J]. Stem Cells, 2015, 33(4):1173-1186.
[45]
Zimolag E, Borowczyk-Michalowska J, Kedracka-Krok S, et al. Electric field as a potential directional cue in homing of bone marrow-derived mesenchymal stem cells to cutaneous wounds[J]. 2017, 1864(2):267-279.
[46]
黄宏,邱伟,陈民佳,等. 干细胞预处理及其保护机制的研究进展[J/CD]. 中华损伤与修复杂志(电子版), 2017, 12(2):138-142.
[47]
关淇帆,张瑶. 预处理后的干细胞治疗缺血性心脏病的研究进展[J]. 心血管康复医学杂志,2016, 25(2):217-219.
[48]
Bidkhori HR, Ahmadiankia N, Matin MM, et al. Chemically primed bone-marrow derived mesenchymal stem cells show enhanced expression of chemokine receptors contributed to their migration capability[J]. Iran J Basic Med Sci, 2016, 19(1):14-19.
[1] 谢卓晏, 罗远利, 乔斌, 李锦瑞, 周志益, 王志刚, 任建丽. 肽功能化载GOD智能响应型相变纳米粒用于乳腺癌超声诊疗的实验研究[J]. 中华医学超声杂志(电子版), 2022, 19(08): 837-846.
[2] 卫杨文祥, 黄浩然, 刘予豪, 陈镇秋, 王海彬, 周驰. 股骨头坏死细胞治疗的前景和挑战[J]. 中华关节外科杂志(电子版), 2023, 17(05): 694-700.
[3] 符卓毅, 唐圣成, 卜俏梅, 徐高兵, 吴安平, 蔡巍, 杨明, 谭海涛. 镁在骨关节炎治疗中的研究进展[J]. 中华关节外科杂志(电子版), 2023, 17(03): 354-362.
[4] 姜博庸, 韩长旭. 间充质干细胞外泌体促进软骨再生的潜在机制研究[J]. 中华关节外科杂志(电子版), 2023, 17(01): 44-51.
[5] 张巧梅, 孙小平, 李冠胜, 邓扬嘉. 针灸对大鼠呼吸机相关性肺炎中性粒细胞归巢及胞外诱捕网的影响[J]. 中华危重症医学杂志(电子版), 2023, 16(04): 265-271.
[6] 周子慧, 李恭驰, 李炳辉, 王知, 刘慧真, 王卉, 邹利军. 细胞自噬在创面愈合中作用的研究进展[J]. 中华损伤与修复杂志(电子版), 2023, 18(06): 542-546.
[7] 陈继秋, 朱世辉. 皮肤牵张装置的临床应用现状[J]. 中华损伤与修复杂志(电子版), 2023, 18(05): 451-453.
[8] 中国老年医学学会烧创伤分会, 中国生物材料学会烧创伤创面修复材料分会. 中国糖尿病足截肢(趾)治疗专家共识(2022年版)[J]. 中华损伤与修复杂志(电子版), 2023, 18(01): 1-9.
[9] 刘甜甜, 李明, 朱含汀, 倪涛, 彭银波, 方勇. 创缘铁过载的临床样本验证与铁过载对小鼠创面愈合的影响[J]. 中华损伤与修复杂志(电子版), 2022, 17(06): 475-481.
[10] 黄晓罡, 牛东升, 闫香果, 张克松, 何军民, 王晓军, 刘媛媛. 局部应用重组人Ⅲ型胶原蛋白水凝胶对糖尿病患者创面愈合的影响[J]. 中华损伤与修复杂志(电子版), 2022, 17(05): 430-434.
[11] 张苗苗, 付倩倩, 赵雅玫, 余小平, 周军利. 慢性创面伴自身免疫性疾病的研究进展[J]. 中华损伤与修复杂志(电子版), 2022, 17(05): 445-449.
[12] 王晓阳, 王静, 韩劼, 孙立元. 两种预处理方法联合光动力治疗肛周尖锐湿疣的疗效观察[J]. 中华实验和临床感染病杂志(电子版), 2023, 17(03): 158-163.
[13] 张文汇, 马森, 徐秋香. 肢体远隔缺血预处理对单孔胸腔镜肺叶切除术后影响分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(02): 239-241.
[14] 陈玉婷, 周影, 陆雅斐, 江滨. 缺氧预处理间充质干细胞的功能及机制研究进展[J]. 中华细胞与干细胞杂志(电子版), 2023, 13(02): 115-120.
[15] 中华医学会消化内镜学分会. 消化内镜超级微创手术创面预处理与抗生素应用专家共识(2023年,北京)[J]. 中华胃肠内镜电子杂志, 2023, 10(02): 83-91.
阅读次数
全文


摘要