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中华损伤与修复杂志(电子版) ›› 2021, Vol. 16 ›› Issue (01) : 1 -5. doi: 10.3877/cma.j.issn.1673-9450.2021.01.001

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间充质干细胞源性外泌体在促创面愈合中的应用与挑战
祁放1, 王达利1,()   
  1. 1. 563003 遵义医科大学附属医院烧伤整形外科
  • 收稿日期:2021-01-10 出版日期:2021-02-01
  • 通信作者: 王达利
  • 基金资助:
    国家自然科学基金(81871570,82072195); 贵州省科技计划项目(黔科合支撑【2016】2910号); 贵州省科技计划项目(黔科合支撑【2020】4Y148号); 贵州省组织损伤修复与再生医学2011协同创新中心(黔教合协同创新字【2015】07)

Application and challenges of exosomes drived from mesenchymal stem cells in wound healing

Fang Qi1, Dali Wang1,()   

  1. 1. Department of Burns and Plastic Surgery, First Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China
  • Received:2021-01-10 Published:2021-02-01
  • Corresponding author: Dali Wang
引用本文:

祁放, 王达利. 间充质干细胞源性外泌体在促创面愈合中的应用与挑战[J/OL]. 中华损伤与修复杂志(电子版), 2021, 16(01): 1-5.

Fang Qi, Dali Wang. Application and challenges of exosomes drived from mesenchymal stem cells in wound healing[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2021, 16(01): 1-5.

间充质干细胞(MSC)能够有效促进各类创面的愈合且已进入临床试验阶段。进一步研究发现MSC通过旁分泌产生的外泌体也具有与MSC等效的生物学作用。基于MSC源性外泌体的"无细胞"疗法具有广阔的应用前景,但其面临的争议与挑战也值得关注。本文就MSC及其源性外泌体的应用进展和争议,以及微环境对其的影响进行简要评述,与读者共同探讨。

Mesenchymal stem cells (MSC) can effectively promote the healing of various wounds and have reached the stage of clinical trials. Further studies have found that exosomes secreted by MSC by paracrine mechanism also have biological effects equivalent to MSC. "Cell-free" therapy based on exosomes drived from MSC has broad application prospects, but the controversy and challenges it faces are also worthy of attention. This paper briefly reviewed the application and existing problems of MSC and exosomes drived from MSC, furthermore, the influence of microenvironment was analyzed and discussed.

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