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中华损伤与修复杂志(电子版) ›› 2022, Vol. 17 ›› Issue (02) : 154 -158. doi: 10.3877/cma.j.issn.1673-9450.2022.02.012

综述

脂肪间充质干细胞外泌体促进创面血管再生的研究进展
曹涛1, 陶克1,()   
  1. 1. 710032 西安,空军军医大学第一附属医院全军烧伤中心 烧伤与皮肤外科
  • 收稿日期:2022-01-21 出版日期:2022-04-01
  • 通信作者: 陶克
  • 基金资助:
    国家自然科学基金(8187080257)

Research progress of adipose mesenchymal stem cell exosomes promoting wound angiogenesis

Tao Cao1, Ke Tao1,()   

  1. 1. Department of Burns and Cutaneous Surgery, Burn Center of PLA, First Affiliated Hospital of Air Force Medical University, Xi′an 710032, China
  • Received:2022-01-21 Published:2022-04-01
  • Corresponding author: Ke Tao
引用本文:

曹涛, 陶克. 脂肪间充质干细胞外泌体促进创面血管再生的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2022, 17(02): 154-158.

Tao Cao, Ke Tao. Research progress of adipose mesenchymal stem cell exosomes promoting wound angiogenesis[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2022, 17(02): 154-158.

创面愈合是机体损伤后细胞、组织在血运重建后进行修复的复杂过程,血管再生是创面治疗的关键;促进血管再生可有效加速创面愈合。研究表明脂肪间充质干细胞(ADSC)可以有效促进血管再生,其外泌体(Exo)可以传递各类细胞因子、miRNA,有效促进血管内皮细胞增殖、迁移、成管;本文通过综述国内外ADSC-Exo在促进创面血管再生作用及机制的相关研究,从促进创面愈合作用、机制研究及各类型材料递送ADSC-Exo策略的研究3个方面探讨ADSC-Exo促进血管再生的作用,为各类创面治疗提供新的思路。

Wound healing is a complex process for cells and tissues to repair after revascularization of injury, in which angiogenesis is the key to wound therapy. Promoting angiogenesis can accelerate wound healing effectively. Studies have shown that adipose-derived mesenchymal stem cells (ADSC) can effectively promote angiogenesis, whose exosomes (Exo) can deliver various cytokines and miRNAs. They can effectively promote the progressments of proliferation, migration and tubular formation of vascular endothelial cells. This paper will review the domestic and foreign studies on the role of ADSC-Exo in promoting wound angiogenesisand its mechanism, and discusse the role of ADSC-Exo in promoting vascular regeneration from three aspects: the role of promoting wound healing, the mechanism and the strategy of ADSC-Exo delivery of various biological materials to provide new ideas for wound treatment.

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