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中华损伤与修复杂志(电子版) ›› 2022, Vol. 17 ›› Issue (03) : 260 -264. doi: 10.3877/cma.j.issn.1673-9450.2022.03.015

综述

髓核间充质干细胞在椎间盘退变修复中的研究进展
胡满1, 赵文杰1, 张钰2, 刘鑫2, 石鹏志1, 王俊武2, 张亮2,†()   
  1. 1. 116044　大连医科大学研究生院；225001　扬州大学临床医学院
    2. 225001　扬州大学临床医学院
  • 收稿日期:2022-03-15 出版日期:2022-06-01
  • 通信作者: 张亮
  • 基金资助:
    国家自然科学基金面上项目(82172462); 广西省自然科学基金面上项目(2018JJA14775); 江苏省青年医学重点人才项目(QNRC2016342); 江苏省妇幼健康科研重点资助项目(F201801); 江苏省高层次卫生人才"六个一工程"拔尖人才科研项目(LGY2019035)

Research progress on the repair of intervertebral disc degeneration with nucleus pulposus-derived mesenchymal stem cell

Man Hu1, Wenjie Zhao1, Yu Zhang2, Xin Liu2, Pengzhi Shi1, Junwu Wang2, Liang Zhang2,†()   

  1. 1. Graduate School of Dalian Medical University, Dalian 116044, China; Yangzhou University School of Clinical Medicine, Yangzhou 225001, China
    2. Yangzhou University School of Clinical Medicine, Yangzhou 225001, China
  • Received:2022-03-15 Published:2022-06-01
  • Corresponding author: Liang Zhang
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引用本文：

胡满, 赵文杰, 张钰, 刘鑫, 石鹏志, 王俊武, 张亮. 髓核间充质干细胞在椎间盘退变修复中的研究进展[J]. 中华损伤与修复杂志(电子版), 2022, 17(03): 260-264.

Man Hu, Wenjie Zhao, Yu Zhang, Xin Liu, Pengzhi Shi, Junwu Wang, Liang Zhang. Research progress on the repair of intervertebral disc degeneration with nucleus pulposus-derived mesenchymal stem cell[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2022, 17(03): 260-264.

间充质干细胞是一种具有自我更新和多向分化能力的多能干细胞。髓核间充质干细胞(NPMSC)作为椎间盘源性的间充质干细胞，在适应椎间盘退变(IDD)后的酸性、低氧、高渗、异常压应力及营养缺乏恶劣微环境中有着天然优势，其可以通过移植、内源性激活及自身的迁移和募集来修复IDD。分析表明，NPMSC在IDD的内源性修复中有着巨大潜力。本文回顾近年来基于NPMSC的IDD修复策略作一综述，以期进一步明确未来研究方向，为寻求IDD的可靠治疗方法提供思路。

关键词: 椎间盘, 髓核间充质干细胞, 椎间盘退变, 修复

Mesenchymal stem cells are pluripotent stem cells with self-renewal and multi-directional differentiation capabilities. Nucleus pulposus-derived mesenchymal stem cell (NPMSC), as intervertebral disc-derived mesenchymal stem cell, has a natural advantage in adapting to the harsh microenvironment of acidity, hypoxia, hyperosmolar, abnormal compressive stress and nutritional deficiency after intervertebral disc degeneration (IDD) and can repair IDD through transplantation, endogenous activation and its own migration and recruitment. The analysis has shown that NPMSC has great potential in the endogenous repair of IDD. This paper reviews the repair strategies of IDD based on NPMSC in recent years, in order to further clarify the future research direction and provide ideas for seeking reliable treatment methods of IDD.

Key words: Intervertebral disc, Nucleus pulposus-derived mesenchymal stem cells, Intervertebral disc degeneration, Repair
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