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中华损伤与修复杂志(电子版) ›› 2026, Vol. 21 ›› Issue (02) : 147 -153. doi: 10.3877/cma.j.issn.1673-9450.2026.02.012

综述

色素上皮衍生因子在糖尿病创面愈合中作用机制的研究进展
朱君佑1, 张骞2, 赵止云3, 甄妙1, 谢举临1, 李天娇3, 舒斌1,()   
  1. 1 510080 广州,中山大学附属第一医院烧伤与创面修复科
    2 410007 武警武汉特勤疗养中心
    3 410013 长沙,中南大学湘雅公共卫生学院
  • 收稿日期:2025-12-24 出版日期:2026-04-01
  • 通信作者: 舒斌
  • 基金资助:
    国家自然科学基金(82572913,82172207)

Role of pigment epithelium-derived factor in diabetic wound healing

Junyou Zhu1, Qian Zhang2, Zhiyun Zhao3, Miao Zhen1, Julin Xie1, Tianjiao Li3, Bin Shu1,()   

  1. 1 Department of Burn and Wound Repair Surgery,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China
    2 Wuhan Special Service Recuperation Center of Armed Police,Wuhan 410007,China
    3 Xiangya School of Public Health,Central South University,Changsha 410013,China
  • Received:2025-12-24 Published:2026-04-01
  • Corresponding author: Bin Shu
引用本文:

朱君佑, 张骞, 赵止云, 甄妙, 谢举临, 李天娇, 舒斌. 色素上皮衍生因子在糖尿病创面愈合中作用机制的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2026, 21(02): 147-153.

Junyou Zhu, Qian Zhang, Zhiyun Zhao, Miao Zhen, Julin Xie, Tianjiao Li, Bin Shu. Role of pigment epithelium-derived factor in diabetic wound healing[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2026, 21(02): 147-153.

糖尿病是一种常见且危害性强的代谢性疾病,截至2024年全球成年糖尿病患者已达约5.89亿,因而成为全球公共卫生的重大课题。高血糖状态可直接造成微血管病变、神经损伤及免疫调节失衡,导致患者创面愈合困难以及感染率、致残率升高。然而,糖尿病创面愈合障碍的发生机制极其复杂,其具体发生发展机制目前仍未完全阐明。色素上皮衍生因子(PEDF)是一种具有多种生物功能的内源性糖蛋白,参与血管生成调控、细胞增殖分化、氧化应激调节及组织重塑等过程,且其表达在正常创面愈合中有明确、有序的阶段性变化,在各愈合阶段均发挥不可替代的作用。因此,糖尿病创面中PEDF表达紊乱被认为是创面难愈的重要分子机制。基于此,下文系统总结了PEDF在糖尿病创面愈合中的作用机制,探讨以PEDF为靶点的潜在干预策略及应用前景,旨在为糖尿病慢性创面的精准治疗提供新的理论依据及分子靶向治疗思路。

Diabetes mellitus is a common and important metabolic disorder, and as of 2024, the global diabetic population has reached approximately 589 million, thus constituting a major public health challenge worldwide. Hyperglycemia promotes microangiopathy, nerve injury, and immune dysregulation, all of which impair wound healing and significantly increase the risk of infection and disability in diabetic patients. However, the mechanisms underlying the initiation and progression of impaired diabetic wound healing remain complex and not fully elucidated. Pigment epithelium-derived factor (PEDF) is a multifunctional endogenous glycoprotein that participates in angiogenesis regulation, cell proliferation and differentiation, oxidative stress modulation, and tissue remodeling. Its expression during normal wound healing is stage-specific and functionally important at each phase of the repair process. In sharp contrast, dysregulated PEDF is now widely regarded as a central molecular mechanism underlying impaired healing in diabetic wounds. This review systematically examines the mechanistic role of PEDF in diabetic wound healing and discusses PEDF-targeted interventions and their clinical prospects, aiming to provide a novel theoretical basis and concrete molecular strategies for the precise treatment of chronic diabetic wounds.

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