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中华损伤与修复杂志(电子版) ›› 2018, Vol. 13 ›› Issue (03) : 230 -233. doi: 10.3877/cma.j.issn.1673-9450.2018.03.015

所属专题: 文献

综述

皮肤成纤维细胞"干"性特征及其在创伤治疗中的应用前景
杜娟1, 刘雪来2,()   
  1. 1. 130021 长春,吉林省人民医院内分泌科
    2. 999077 香港大学李嘉诚医学院外科学系;050000 石家庄,河北医科大学第二医院小儿外科
  • 收稿日期:2018-04-23 出版日期:2018-06-01
  • 通信作者: 刘雪来
  • 基金资助:
    深圳市卫生系统科研项目(20150409201); 河北医科大学第二医院课题(2h2017002)

"Stem" characteristics of dermal fibroblast and its future application in the wound healing

Juan Du1, Xuelai Liu2,()   

  1. 1. Department of Endocrinology, the People′s Hospital of Jilin Province, Changchun 130021, China
    2. Department of Surgery, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong 999077, China; Department of Pediatric Surgery, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
  • Received:2018-04-23 Published:2018-06-01
  • Corresponding author: Xuelai Liu
  • About author:
    Corresponding author: Liu Xuelai, Email:
引用本文:

杜娟, 刘雪来. 皮肤成纤维细胞"干"性特征及其在创伤治疗中的应用前景[J/OL]. 中华损伤与修复杂志(电子版), 2018, 13(03): 230-233.

Juan Du, Xuelai Liu. "Stem" characteristics of dermal fibroblast and its future application in the wound healing[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2018, 13(03): 230-233.

诱导多能干细胞(iPSC)技术将干细胞的研究和应用带入一个崭新的阶段,人们在重视iPSC的同时,也开始重新审视成纤维细胞(FB)。研究发现,皮肤FB在不同微环境下可分化为不同的细胞。本文将介绍皮肤FB的来源和生物学特性,重点总结FB的干细胞特征,包括向iPSC、肌细胞、软骨细胞及成骨细胞、神经细胞和脂肪细胞的分化,以及FB生物学优势,最后将展望FB在皮肤伤口和骨折等创伤愈合转化医学中的应用。

The induced pluripotent stem cell (iPSC) technology is one of de novo approaches in regeneration medicine and leads to a new research field these years. Meanwhile the fibroblast(FB) attracted wide attention once more. The researchers have found that the FB could be induced into different type cells in variable medium or environment. Thus the authors review the FB potential "stem" characteristics and its promotion to the wound healing. So in this review article, the sorts and biological of FB are introduced at first. Secondly, the "stem cell" characteristics of FB including transition into iPSC, myofibroblat, chondrogenic and cartilage, neuron and fat tissue etc. are summed up. Thirdly, the biological values of FB are reviewed briefly. At last the application of FB in the future clinical practice are expected.

图1 皮肤FB的"干"性特征模式图,多种干细胞可分化为皮肤FB,反之,FB可分化为各种功能细胞。FB为成纤维细胞
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