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中华损伤与修复杂志(电子版) ›› 2018, Vol. 13 ›› Issue (02) : 134 -138. doi: 10.3877/cma.j.issn.1673-9450.2018.02.013

所属专题: 文献

综述

干细胞在椎间盘退变生物学治疗中的研究进展
南利平1, 冯新民2, 张亮2,(), 刘洋1, 王峰1, 周诗丰3   
  1. 1. 116044 大连医科大学;225001 扬州大学临床医学院
    2. 225001 扬州大学临床医学院;225001 扬州,江苏省苏北人民医院骨科研究所
    3. 225001 扬州大学临床医学院
  • 收稿日期:2018-02-02 出版日期:2018-04-01
  • 通信作者: 张亮
  • 基金资助:
    国家自然科学基金青年基金(81401830)

Research progresses of stem cell in the treatment of intervertebral disc degenerative disease

Liping Nan1, Xinmin Feng2, Liang Zhang2,(), Yang Liu1, Feng Wang1, Shifeng Zhou3   

  1. 1. Dalian Medical University, Dalian 116044, China; Department of Orthopedics, Clinical Medical College of Yangzhou University, Yangzhou 225001, China
    2. Department of Orthopedics, Clinical Medical College of Yangzhou University, Yangzhou 225001, China; Institute of Orthopedics, Northern Jiangsu People′s Hospital, Yangzhou 225001, China
    3. Department of Orthopedics, Clinical Medical College of Yangzhou University, Yangzhou 225001, China
  • Received:2018-02-02 Published:2018-04-01
  • Corresponding author: Liang Zhang
  • About author:
    Corresponding author: Zhang Liang, Email:
引用本文:

南利平, 冯新民, 张亮, 刘洋, 王峰, 周诗丰. 干细胞在椎间盘退变生物学治疗中的研究进展[J]. 中华损伤与修复杂志(电子版), 2018, 13(02): 134-138.

Liping Nan, Xinmin Feng, Liang Zhang, Yang Liu, Feng Wang, Shifeng Zhou. Research progresses of stem cell in the treatment of intervertebral disc degenerative disease[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2018, 13(02): 134-138.

腰痛是一种常见的肌肉骨骼症状,与椎间盘退变密切相关。常规保守或传统手术疗法仅针对临床症状,并未从根本上解决椎间盘退变问题。以干细胞为基础的生物学治疗基于椎间盘退变的始发因素可以为椎间盘退变性疾病提供一种新的治疗思路。目前常用的干细胞类型有间充质干细胞、诱导多能干细胞、造血干细胞及胚胎干细胞等。体内外研究报道提示干细胞疗法具有促进退变椎间盘恢复的作用,将干细胞应用于椎间盘退变性疾病的治疗具有光明前途,但长期疗效有待于进一步研究。

Low back pain is a common musculoskeletal symptom associated with intervertebral disc degeneration. However, the conservative treatment or surgical treatment just target the clinical symptoms instead of the pathophysiology involved in the degenerative process. The therapeutic strategies based on stem cells and pathophysiology of the degenerative process can provide a new treatment for intervertebral disc degenerative diseases. The common stem cells include mesenchymal stem cells, induced pluripotent stem cells, hematopoietic stem cells and embryonic stem cells. In literature the potential use of different stem cells for intervertebral disc regeneration in vivo and in vitro has already been reported in reproducible animal models as well as to be safe in human clinical trials. The application of stem cell therapy has shown promise in becoming a powerful tool in the future treatment of intervertebral disc degenerative diseases.

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