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中华损伤与修复杂志(电子版) ›› 2020, Vol. 15 ›› Issue (01) : 67 -69. doi: 10.3877/cma.j.issn.1673-9450.2020.01.012

所属专题: 文献

综述

间充质干细胞源性外泌体在创面修复中的研究进展
王宏宇1, 刘玲英2, 巴特3,()   
  1. 1. 010059 呼和浩特,内蒙古医科大学;014010 包头,内蒙古医科大学第三附属医院烧伤科
    2. 100048 北京,解放军总医院第四医学中心烧伤整形科
    3. 014010 包头,内蒙古医科大学第三附属医院烧伤科
  • 收稿日期:2019-12-31 出版日期:2020-02-01
  • 通信作者: 巴特
  • 基金资助:
    国家自然科学基金青年项目(81701900); 解放军总医院科技创新苗圃基金项目(17KMM28); 解放军总医院扶持基金项目(2017FC-304M-CXYY-01); 解放军总医院转化医学项目(2017TM-029); 内蒙古自治区自然科学基金项目(2015MS0815); 内蒙古医科大学科技百万工程(联合)项目(YKD2016KJBW(LH)041)

Research progress of mesenchymal stem cell-derived exosomes in wound repair

Hongyu Wang1, Lingying Liu2, Te Ba3,()   

  1. 1. Inner Mongolia Medical University, Huhhot 010059, China;Department of Burns, Third Affiliated Hospital of Inner Mongolia Medical University, Baotou 014010, China
    2. Department of Burns and Plastic Surgery, Fourth Medical Center of PLA General Hospital, Beijing 100048, China
    3. Department of Burns, Third Affiliated Hospital of Inner Mongolia Medical University, Baotou 014010, China
  • Received:2019-12-31 Published:2020-02-01
  • Corresponding author: Te Ba
  • About author:
    Corresponding author: Ba Te, Email:
引用本文:

王宏宇, 刘玲英, 巴特. 间充质干细胞源性外泌体在创面修复中的研究进展[J]. 中华损伤与修复杂志(电子版), 2020, 15(01): 67-69.

Hongyu Wang, Lingying Liu, Te Ba. Research progress of mesenchymal stem cell-derived exosomes in wound repair[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2020, 15(01): 67-69.

外泌体是由细胞通过旁分泌途径产生的一种直径在30~100 nm的囊泡结构。作为活细胞分泌的一种亚细胞成分,外泌体广泛参与细胞间的信息交流。多项研究表明,间充质干细胞源性外泌体调控创面修复的多个过程。它可以通过抑制创面过度炎症反应,促进创面血管新生,促进成纤维细胞增殖、迁移,以及抑制创面瘢痕形成来促进创面的修复与再生。本文就间充质干细胞源性外泌体在创面修复中的作用及相关机制进行综述,为外泌体在临床中的应用提供依据。

Exosomes are a vesicle structure with a diameter of about 30 to 100 nm produced by cells through the paracrine pathway. As a subcellular component secreted by living cells, exosomes are widely involved in the communication of information between cells. A number of studies have shown that exosomes derived from mesenchymal stem cells regulate multiple processes of wound repair. It can promote the repair and regeneration of wounds by inhibiting the excessive inflammation response of the wound, promoting the angiogenesis of the wound, promoting the proliferation and migration of fibroblasts, and inhibiting the formation of wound scars. This article reviews the role of mesenchymal stem cell-derived exosomes in wound repair and related mechanisms, and provides a basis for clinical application of exosomes.

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