切换至 "中华医学电子期刊资源库"

中华损伤与修复杂志(电子版) ›› 2022, Vol. 17 ›› Issue (03) : 242 -246. doi: 10.3877/cma.j.issn.1673-9450.2022.03.011

论著

糖尿病患者行包皮环切缝合器手术可行性分析
何溢发1, 赵曼均1, 焦守阔1, 马寅超1, 温鲤键1, 屈小骅1, 吴学杰1, 单玉喜1, 谢尔凡2,()   
  1. 1. 215010 南京医科大学附属明基医院苏州院区泌尿外科
    2. 215010 南京医科大学附属明基医院烧伤整形科
  • 收稿日期:2022-03-27 出版日期:2022-06-01
  • 通信作者: 谢尔凡
  • 基金资助:
    苏州市科技发展计划科研项目(SKJYD2021055); 南京医科大学科技发展基金项目(NMUB2019251); 苏州明基医院院内科研基金项目(SZMJ2001)

Feasibility analysis of circumcision suture device for diabetic patients

Yifa He1, Manjun Zhao1, Shoukuo Jiao1, Yinchao Ma1, Lijian Wen1, Xiaohua Qu1, Xuejie Wu1, Yuxi Shan1, Erfan Xie2,()   

  1. 1. Department of Urology Surgery, Suzhou District of BenQ Medical Center, Affiliated BenQ Hospital of Nanjing Medical University, Suzhou 215010, China
    2. Department of Burns and Plastic Surgery, Suzhou District of BenQ Medical Center, Affiliated BenQ Hospital of Nanjing Medical University, Suzhou 215010, China
  • Received:2022-03-27 Published:2022-06-01
  • Corresponding author: Erfan Xie
引用本文:

何溢发, 赵曼均, 焦守阔, 马寅超, 温鲤键, 屈小骅, 吴学杰, 单玉喜, 谢尔凡. 糖尿病患者行包皮环切缝合器手术可行性分析[J/OL]. 中华损伤与修复杂志(电子版), 2022, 17(03): 242-246.

Yifa He, Manjun Zhao, Shoukuo Jiao, Yinchao Ma, Lijian Wen, Xiaohua Qu, Xuejie Wu, Yuxi Shan, Erfan Xie. Feasibility analysis of circumcision suture device for diabetic patients[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2022, 17(03): 242-246.

目的

探讨糖尿病患者采用包皮环切缝合器手术的可行性。

方法

回顾性研究南京医科大学附属明基医院苏州院区2019年12月至2022年2月收治的行包皮环切术的89例糖尿病患者病历资料。依据切除包皮的手术方式不同,分为包皮环切缝合器手术组(n=36)、传统包皮环切手术组(n=53)。患者入院后完善术前常规化验和检查,控制血糖,包皮环切缝合器手术组患者术中选择相应型号的一次性包皮环切缝合器切割、缝合包皮;传统包皮环切手术组患者术中距离冠状沟0.5~1.0 cm处用组织剪剪去多余包皮,电刀严密止血后用可吸收线间断缝合。2组患者均用纱布和弹力绷带加压包扎伤口。术后2组患者均予以口服第2代头孢菌素类抗生素3 d预防感染,术后第1天予以更换纱布和弹力绷带,之后每2 d更换1次,直至伤口愈合拆除纱布和弹力绷带为止。比较2组患者平均手术时间、平均术中出血量、术后并发症以及记录包皮环切缝合器手术组吻合器损伤龟头例数。数据行Mann-Whitney U检验、χ2检验和Fisher确切概率法检验。

结果

包皮环切缝合器手术组患者平均手术时间[10.0(6.3,14.8) min]和平均术中出血量[1.0(1.0,2.0) mL]显著短于及少于传统包皮环切手术组[28.0(23.0,33.0)min、2.0(1.0,5.0) mL],差异均有统计学意义(Z=-7.787、-3.884,P<0.05)。术后包皮环切缝合器手术组伤口瘀斑8例(22.2%),高于传统包皮环切手术组[2例(3.8%)],差异有统计学意义(χ2=5.583,P=0.018)。包皮环切缝合器手术组术后伤口血肿5例(13.9%)、伤口感染5例(13.9%)、伤口全部裂开5例(13.9%),与传统包皮环切手术组(0、0、0)比,差异均有统计学意义(P=0.009、0.009、0.009)。包皮环切缝合器手术组术后未出现伤口局部裂开,与传统包皮环切手术组[1例(1.9%)]比较,差异无统计学意义(P=0.596)。伤口瘀斑较为常见可自行消退;增加弹力绷带层数基础上加压包扎2 d伤口血肿消失;针对伤口感染、伤口全部裂开,予以拆除全部包皮吻合器的钉和硅胶垫片后消毒、包扎,待伤口感染控制后,用可吸收线重新缝合;针对伤口局部裂开应用苯扎氯铵局部消毒。包皮环切缝合器手术组患者术中均未出现吻合器损伤龟头。

结论

术前经过严格筛选和沟通后的糖尿病患者行包皮环切缝合器是安全可行的,而且具有手术便捷和手术体验较好等优点。

Objective

To investigate the safety and effectiveness of circumcision suture device in patients with diabetes mellitus.

Methods

A retrospective study was conducted on the clinical data of 89 diabetic patients who had undergone circumcision and met the inclusion criteria admitted to Suzhou District of BenQ Medical Center, Affiliated BenQ Hospital of Nanjing Medical University from December 2019 to February 2022. According to the different surgical methods of circumcision, they were divided into the circumcision suture device group (n= 36) and the traditional circumcision group (n=53). After the patients were admitted to the hospital, the routine test and examination before operation were accomplished and the blood glucose was controled. The corresponding type of disposable circumcision suture device was chose to cut and suture the foreskin in the circumcision suture device group. In the traditional circumcision group, the excess prepuce was cut off with tissue scissors at a distance of 0.5-1.0 cm from the coronal sulcus. After hemostasis by electrotome, the patients were sutured intermittently with absorbable thread. Patients in both groups were treated with gauze and elastic bandage. After surgery, patients in both groups received oral second-generation cephalosporin antibiotics for 3 days to prevent infection. Gauze and elastic bandage were replaced on the first day after surgery, and then replaced every 2 days until wound was healed and gauze and elastic bandage were removed. The average operation time, average intraoperative blood loss and postoperative complications were compared between the two groups, and the number of cases of balanus injury caused by stapling device in the circumcision suture device group was recorded. Data were processed with Mann Whitney U test, chi-square test and Fisher′s exact test.

Results

The average operation time [10.0 (6.3, 14.8) min] and intraoperative blood loss [1.0 (1.0, 2.0) mL] in the circumcision suture device group were significantly lower than those in the traditional circumcision group [28.0 (23.0, 33.0) min] and [2.0 (1.0, 5.0) mL], and the differences were statistically significant (Z=-7.787, -3.884; P<0.05). There were 8 cases (22.2%) of wound ecchymosis in the circumcision suture device group after operation, which was higher than that in the traditional circumcision group [2 cases (3.8%)], the difference was statistically significant (χ2=5.583, P=0.018). There were 5 cases (13.9%) of wound hematoma, 5 cases (13.9%) of wound infection and 5 cases (13.9%) of total wound dehiscication in the circumcision suture device group, which were higher than those in the traditional circumcision group (0, 0, 0), the differences were statistically significant (P=0.009, 0.009, 0.009). There was no local wound dehiscication in the circumcision suture group, compared with the traditional circumcision group [1 case (1.9%)], there was no statistically significant difference (P=0.596). Ecchymosis of the wound was more common and would subside spontaneously. Postoperative wound hematoma could disappear after 2 days of compression dressing based on increasing the number of elastic bandage layers. For wound infection and total wound dehiscication, all foreskin staplers and silicone spacers should be removed and then disinfected and bandaged. After wound infection was controlled, absorbable thread was used for resuture. Partial wound dehiscication was needed local disinfection with benzalkonium chloramine. None of the patients in the circumcision suture group had balanus injury caused by stapling device during operation.

Conclusion

It is safe and feasible for patients with diabetes mellitus to receive the circumcision suture device after strict screening and communication before operation, and it has the advantages of convenient operation and good surgical experience.

表1 2组需行手术切除包皮的糖尿病患者一般资料比较
表2 2组需行手术切除包皮的糖尿病患者观测指标比较
[1]
Omole F, Smith W, Carter-Wicker K. Newborn Circumcision Techniques[J]. Am Fam Physician, 2020, 101(11): 680-685.
[2]
Farley TM, Samuelson J, Grabowski MK, et al. Impact of male circumcision on risk of HIV infection in men in a changing epidemic context-systematic review and meta-analysis[J]. J Int AIDS Soc, 2020, 23(6): e25490.
[3]
Mehta SD, Moses S, Parker CB, et al. Circumcision status and incident herpes simplex virus type 2 infection, genital ulcer disease, and HIV infection[J]. AIDS, 2012, 26(9): 1141-1149.
[4]
Piontek EA, Albani JM. Male Circumcision: The Clinical Implications Are More Than Skin Deep[J]. Mo Med, 2019, 116(1): 35-37.
[5]
Jiang W, Fu JL, Guo WL, et al. A Modified Pressure Dressing to Avoid Severe Bleeding After Circumcision With a Disposable Circumcision Suture Device and a Discussion on the Mechanism of Bleeding With the Disposable Circumcision Suture Device[J]. Sex Med, 2021, 9(2): 100288.
[6]
林剑峰,粱福律,涂建平,等. 一次性包皮环切缝合器与吻合器治疗包皮过长和包茎的临床疗效对比[J]. 中国性科学 2016, 25(11): 22-24.
[7]
赵志军,彭丹丹,胡玲,等. 高血糖及肥胖对闭合性胆系手术结局的影响[J]. 中华内分泌外科杂志 2022, 16(1): 84-88.
[8]
景治安,刘彦军,李纪华,等. 包皮环切缝合器与环形吻合器及传统包皮环切术的前瞻性临床研究[J]. 中国现代医学杂志 2014, 24(3): 47-51.
[9]
唐飞,李玉洁,史彦彬,等. 一次性包皮切割缝合器在成人包皮环切术中的应用[J]. 中国性科学 2017, 26(8): 29-31.
[10]
方冬,袁亦铭,郑卫,等. 采用一次性包皮环切缝合器的手术效果和术后管理[J]. 中国性科学 2017, 26(11): 26-30.
[11]
Yenehun Worku G, Belete Alamneh Y, Erku Abegaz W. Prevalence of Bacterial Urinary Tract Infection and Antimicrobial Susceptibility Patterns Among Diabetes Mellitus Patients Attending Zewditu Memorial Hospital, Addis Ababa, Ethiopia[J]. Infect Drug Resist, 2021, 14: 1441-1454.
[12]
张爱玲,李朵璐,周玉冰,等. 达格列净与2型糖尿病患者泌尿生殖系统感染相关性的Meta分析[J]. 医药导报 2019, 38(5): 650-655.
[13]
施勇,夏俊生,刘正建,等. 商环、传统包皮环切术和包皮切割缝合器的临床对比研究[J]. 中国男科学杂志 2018, 32(5): 55-59.
[14]
谢晓强,杨恩明,杨水法,等. 两种不同类型的一次性包皮缝合器行包皮环切术的疗效比较[J]. 临床泌尿外科杂志 2020, 35(2): 143-145, 148.
[15]
Shofler D, Rai V, Mansager S, et al.Impact of resolvin mediators in the immunopathology of diabetes and wound healing[J]. Expert Rev Clin Immunol, 2021, 17(6): 681-690.
[16]
Hellmann J, Tang Y, Spite M. Proresolving lipid mediators and diabetic wound healing[J]. Curr Opin Endocrinol Diabetes Obes, 2012, 19(2): 104-108.
[17]
Freire MO, Dalli J, Serhan CN, et al. Neutrophil Resolvin E1 Receptor Expression and Function in Type 2 Diabetes[J]. J Immunol, 2017, 198(2): 718-728.
[18]
Patel S, Srivastava S, Singh MR, et al. Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing[J]. Biomed Pharmacother, 2019, 112: 108615.
[19]
王科,晁生武. 创面愈合相关机制的研究进展[J/CD]. 中华损伤与修复杂志(电子版), 2021, 16(1): 81-84.
[20]
Burgess JL, Wyant WA, Abdo Abujamra B, et al. Diabetic Wound-Healing Science[J]. Medicina (Kaunas), 2021, 57(10): 1072.
[21]
高仪轩,周彪,巴特,等. 新型敷料在创面修复中的应用与进展[J/CD]. 中华损伤与修复杂志(电子版), 2022, 17(1): 68-71.
[1] 曹雯佳, 刘学兵, 罗安果, 钟释敏, 邓岚, 王玉琳, 李赵欢. 超声矢量血流成像对2型糖尿病患者颈动脉壁剪切应力的研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(07): 709-717.
[2] 王杰, 袁泉, 王玥琦, 乔佳君, 谭春丽, 夏仲元, 刘守尧. 溃疡油在糖尿病足溃疡治疗中的应用效果及安全性观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 480-484.
[3] 徐志刚, 曹涛, 何亭, 李博奥, 魏婧韬, 张栋梁, 官浩, 杨薛康. 采用抗生素骨水泥治疗糖尿病患者心脏术后胸骨骨髓炎的临床效果观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 498-502.
[4] 姜珊, 李湘燕, 田硕涵, 温冰, 何睿, 齐心. 采用优化抗感染治疗模式改善糖尿病足感染预后的临床观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(05): 398-403.
[5] 别瑶, 曹志斌, 辛静, 王健楠, 惠宗光. 应用基质血管成分细胞治疗糖尿病足溃疡的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(05): 453-456.
[6] 谢芬, 陈洁, 张媛媛, 刘茜, 胡芬, 李恭驰, 李炳辉, 金环. 移动健康管理模式在糖尿病足管理中的应用效果观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(04): 335-340.
[7] 孟令凯, 李大勇, 王宁, 王桂明, 张炳南, 李若彤, 潘立峰. 袖状胃切除术对肥胖伴2型糖尿病大鼠的作用及机制研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 638-642.
[8] 李猛, 姜腊, 董磊, 吴情, 贾犇黎. 腹腔镜胃袖状切除术治疗肥胖合并2型糖尿病及脂肪胰的临床研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(05): 554-557.
[9] 严虹霞, 王晓娟, 张毅勋. 2 型糖尿病对结直肠癌患者肿瘤标记物、临床病理及预后的影响[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 483-487.
[10] 周学锋, 董哲毅, 冯哲, 蔡广研, 陈香美. 糖尿病肾脏疾病中西医结合诊疗指南计划书[J/OL]. 中华肾病研究电子杂志, 2024, 13(06): 301-305.
[11] 杜军霞, 赵小淋, 王浩然, 高志远, 王曼茜, 万楠熙, 张冬, 丁潇楠, 任琴琴, 段颖洁, 汤力, 朱晗玉. 2 型糖尿病的血液透析患者肠道微生物组学高通量测序分析[J/OL]. 中华肾病研究电子杂志, 2024, 13(06): 313-320.
[12] 邱岭, 朱旭丽, 浦坚, 邢苗苗, 吴佳玲. 糖尿病肾病患者肠道菌群生态特点与胃肠道功能障碍的关联性研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(05): 453-458.
[13] 李玺, 蔡芸莹, 张永红, 苏恒. 假性软骨发育不全合并1型糖尿病一例[J/OL]. 中华临床医师杂志(电子版), 2024, 18(05): 518-520.
[14] 王璇, 娜扎开提·尼加提, 雒洋洋, 蒋升. 皮肤晚期糖基化终末产物浓度与2型糖尿病微血管并发症的相关性[J/OL]. 中华临床医师杂志(电子版), 2024, 18(05): 447-454.
[15] 王星, 陈园, 热孜万古丽·乌斯曼, 郭艳英. T2DM、Obesity、NASH、PCOS共同致病因素相关的分子机制[J/OL]. 中华临床医师杂志(电子版), 2024, 18(05): 481-490.
阅读次数
全文


摘要