切换至 "中华医学电子期刊资源库"

中华损伤与修复杂志(电子版) ›› 2022, Vol. 17 ›› Issue (05) : 450 -453. doi: 10.3877/cma.j.issn.1673-9450.2022.05.013

综述

外泌型汗腺参与创面愈合的研究进展
尚强强1, 王凌峰2,(), 巴特2, 曹胜军2, 周彪2, 李全2, 侯智慧2, 闫增强2, 陈强2   
  1. 1. 010000 呼和浩特,内蒙古医科大学第三临床医学院
    2. 014000 包头,内蒙古医科大学第三附属医院,内蒙古包钢医院烧伤外科
  • 收稿日期:2022-07-25 出版日期:2022-10-01
  • 通信作者: 王凌峰
  • 基金资助:
    国家自然科学基金(882060348)

Advances in research on the involvement of eccrine sweat glands in wound healing

Qiangqiang Shang1, Lingfeng Wang2,(), Te Ba2, Shengjun Cao2, Biao Zhou2, Quan Li2, Zhihui Hou2, Zengqiang Yan2, Qiang Chen2   

  1. 1. Third Clinical Medical College of Inner Mongolia Medical University, Hohhot 010000, China
    2. Department of Burn Surgery, Third Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Baogang Hospital, Baotou 014000, China
  • Received:2022-07-25 Published:2022-10-01
  • Corresponding author: Lingfeng Wang
引用本文:

尚强强, 王凌峰, 巴特, 曹胜军, 周彪, 李全, 侯智慧, 闫增强, 陈强. 外泌型汗腺参与创面愈合的研究进展[J]. 中华损伤与修复杂志(电子版), 2022, 17(05): 450-453.

Qiangqiang Shang, Lingfeng Wang, Te Ba, Shengjun Cao, Biao Zhou, Quan Li, Zhihui Hou, Zengqiang Yan, Qiang Chen. Advances in research on the involvement of eccrine sweat glands in wound healing[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2022, 17(05): 450-453.

表皮和毛囊的干细胞都参与皮肤创面的愈合,但人们对外泌型汗腺在创面愈合过程中的作用知之甚少。本文简述了外泌型汗腺的结构特点与发育过程、外泌型汗腺细胞参与创面再上皮化、血管化的作用和机制以及汗腺类器官体外构建的实验研究,这些实验研究分析表明了外泌型汗腺不仅具有分泌汗液调节体温的作用,而且在参与创面再上皮化、血管化中也具有重要作用,由此指出体外汗腺类器官的培育不仅能实现皮肤功能重建,也能参与创面愈合。

Stem cells from both the epidermis and hair follicles are involved in the healing of skin wounds, but little is known about the role of eccrine sweat glands in the process of wound healing. This paper briefly describes the structural characteristics and developmental process of eccrine sweat glands, the role and mechanism of eccrine sweat gland cells involved in wound re-epithelialisation and vascularisation, and experimental studies on the in vitro construction of sweat gland-like organs. The analysis of these experimental studies has shown that eccrine sweat glands not only have a role in the regulation of body temperature through the secretion of sweat, but also play an important role in the re-epithelialisation and vascularisation of wounds, suggesting that the cultivation of sweat gland-like organs in vitro can not only lead to the reconstruction of skin function, but also to the healing of wounds.

[1]
Harris-Tryon TA, Grice EA. Microbiota and maintenance of skin barrier function[J]. Science, 2022, 376(6596): 940-945.
[2]
Gonzales KAU, Fuchs E. Skin and Its Regenerative Powers: An Alliance between Stem Cells and Their Niche[J]. Dev Cell, 2017, 43(4): 387-401.
[3]
Monavarian M, Kader S, Moeinzadeh S, et al. Regenerative Scar-Free Skin Wound Healing[J]. Tissue Eng Part B Rev, 2019, 25(4): 294-311.
[4]
Wang PH, Huang BS, Horng HC, et al. Wound healing[J]. J Chin Med Assoc, 2018, 81(2): 94-101.
[5]
Lu C, Fuchs E. Sweat gland progenitors in development, homeostasis, and wound repair[J]. Cold Spring Harb Perspect Med, 2014, 4(2): a015222..
[6]
Kabashima K, Honda T, Ginhoux F, et al. The immunological anatomy of the skin[J]. Nat Rev Immunol, 2019, 19(1): 19-30.
[7]
Baker LB. Physiology of sweat gland function: The roles of sweating and sweat composition in human health[J]. Temperature (Austin), 2019, 6(3): 211-259.
[8]
刘煜凡,黄沙,付小兵. 皮肤附属器汗腺发育及功能的机制研究[J]. 生命科学2020, 32(3): 219-226.
[9]
Lu CP, Polak L, Rocha AS, et al. Identification of stem cell populations in sweat glands and ducts reveals roles in homeostasis and wound repair[J]. Cell, 2012, 150(1): 136-150.
[10]
郎东浩,巴特,曹胜军,等. 影响汗腺发育的信号通路及其参与汗腺样细胞体外重建的研究进展[J]. 中华烧伤与创面修复杂志2022, 38(2): 195-200.
[11]
Bovell DL. The evolution of eccrine sweat gland research towards developing a model for human sweat gland function[J]. Exp Dermatol, 2018, 27(5): 544-550.
[12]
Chen R, Zhu Z, Ji S, et al. Sweat gland regeneration: Current strategies and future opportunities[J]. Biomaterials, 2020, 255: 120201.
[13]
Biedermann T, Pontiggia L, Böttcher-Haberzeth S, et al. Human eccrine sweat gland cells can reconstitute a stratified epidermis[J]. J Invest Dermatol, 2010, 130(8): 1996-2009.
[14]
Diao J, Liu J, Wang S, et al. Sweat gland organoids contribute to cutaneous wound healing and sweat gland regeneration[J]. Cell Death Dis, 2019, 10(3): 238.
[15]
陈润开,付小兵,孙晓艳. 体外构建工程化汗腺类器官的初步研究[J]. 解放军医学杂志2020, 45(4): 384-390.
[16]
Danner S, Kremer M, Petschnik AE, et al. The use of human sweat gland-derived stem cells for enhancing vascularization during dermal regeneration[J]. J Invest Dermatol, 2012, 132(6): 1707-1716.
[17]
Rittié L, Sachs DL, Orringer JS, et al. Eccrine sweat glands are major contributors to reepithelialization of human wounds[J]. Am J Pathol, 2013, 182(1): 163-171.
[18]
Sun X, Xiang J, Chen R, et al. Sweat Gland Organoids Originating from Reprogrammed Epidermal Keratinocytes Functionally Recapitulated Damaged Skin[J]. Adv Sci (Weinh), 2021, 8(22): e2103079.
[19]
Zhang M, Li H, Chen L, et al. Three-dimensional reconstructed eccrine sweat glands with vascularization and cholinergic and adrenergic innervation[J]. J Mol Histol, 2018, 49(4): 339-345.
[20]
Kuhnke JL, Keast D, Rosenthal S, et al. Health professionals′ perspectives on delivering patient-focused wound management: a qualitative study[J]. J Wound Care, 2019, 28(Sup7): S4-S13.
[21]
Jeschke MG, van Baar ME, Choudhry MA, et al. Burn injury[J]. Nat Rev Dis Primers, 2020, 6(1): 11.
[22]
de Groot SC, Ulrich MMW, Gho CG, et al. Back to the Future: From Appendage Development Toward Future Human Hair Follicle Neogenesis[J]. Front Cell Dev Biol, 2021, 9: 661787.
[23]
Rossi G, Manfrin A, Lutolf MP. Progress and potential in organoid research[J]. Nat Rev Genet, 2018, 19(11): 671-687.
[24]
Kim W, Gwon Y, Park S, et al. Therapeutic strategies of three-dimensional stem cell spheroids and organoids for tissue repair and regeneration[J]. Bioact Mater, 2022, 19: 50-74.
[25]
Lee J, Koehler KR. Skin organoids: A new human model for developmental and translational research[J]. Exp Dermatol, 2021, 30(4): 613-620.
[26]
Sun H, Zhang YX, Li YM. Generation of Skin Organoids: Potential Opportunities and Challenges[J]. Front Cell Dev Biol, 2021, 9: 709824.
[1] 赵雅玫, 谢斌, 陈艳, 吴健. 抗生素骨水泥联合负压封闭引流对糖尿病足溃疡临床疗效的荟萃分析[J]. 中华损伤与修复杂志(电子版), 2023, 18(05): 427-433.
[2] 何雪锋, 赵世新, 李珮珊, 刘恒登, 谢举临. 卡奴卡叶提取物通过增强真皮成纤维细胞功能促进大鼠创面修复的效果观察[J]. 中华损伤与修复杂志(电子版), 2023, 18(05): 405-412.
[3] 汪国建, 谭雨龙, 龙爽, 吕晓凡, 赵娜, 冉新泽, 王军平, 王涛. 高温高湿环境暴露对重度放创复合伤小鼠损伤恢复的影响[J]. 中华损伤与修复杂志(电子版), 2023, 18(04): 285-292.
[4] 程飚. 浓缩血小板制品在创面修复中应用与思考[J]. 中华损伤与修复杂志(电子版), 2023, 18(03): 276-276.
[5] 何泽亮, 李锦, 张程亮, 随振阳, 安亮恩, 刘玲玲, 姚媛媛, 张聚磊, 仇树林, 李晓东. 采用超声清创联合负压吸引疗法治疗深度烧伤溶痂创面的临床观察[J]. 中华损伤与修复杂志(电子版), 2023, 18(02): 123-127.
[6] 曹涛, 陶克. 脂肪间充质干细胞外泌体促进创面血管再生的研究进展[J]. 中华损伤与修复杂志(电子版), 2022, 17(02): 154-158.
[7] 郑刚, 谢志, 黄涛, 谷才之. 自体邮票植皮术联合冲洗治疗在烧伤患者中的疗效观察[J]. 中华损伤与修复杂志(电子版), 2022, 17(02): 141-144.
[8] 李武国, 陈伟, 苏乔, 李雯雯, 赵广银, 杨宇童, 刘长琳. 不同处理因素对结直肠癌类器官奥沙利铂敏感性测试结果的影响研究[J]. 中华普通外科学文献(电子版), 2021, 15(06): 418-424.
[9] 陈旭渊, 罗仕云, 李文忠, 李毅. 腺源性肛瘘经手术治疗后创面愈合困难的危险因素分析[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 82-85.
[10] 赵子祯, 严紫娟, 王家传. 脑类器官培养技术进展及其在缺血性脑卒中损伤修复中的应用[J]. 中华细胞与干细胞杂志(电子版), 2023, 13(02): 121-128.
[11] 高原, 盛伟, 黄国英. 多能干细胞在体外心脏模型构建研究中的应用[J]. 中华细胞与干细胞杂志(电子版), 2022, 12(05): 314-318.
[12] 张小佐, 霍海芹, 谭建新, 张芳, 冯浩洋, 许争峰. 多能干细胞体外分化为类神经管模型的研究进展[J]. 中华细胞与干细胞杂志(电子版), 2022, 12(01): 45-50.
[13] 阎凯, 付雍, 章正涛, 卢文峰, 王毅州, 巫国谊, 张海斌. 中晚期肝癌疗效预测模型暨肝癌类器官模型研究进展[J]. 中华肝脏外科手术学电子杂志, 2023, 12(03): 348-351.
[14] 王璐, 黄楚月, 李志利, 王一, 孔德松, 刘飞, 樊志敏. 患者来源的结直肠癌类器官模型的构建及其在有毒中药抗癌活性评价中的应用[J]. 中华结直肠疾病电子杂志, 2022, 11(04): 343-348.
[15] 王一, 吴小倩, 黄伟芳, 裴斌, 尚芳, 孔德松, 王小峰, 朱勇, 姚航, 刘飞, 樊志敏. 结直肠癌类器官生物样本库的建立和应用研究进展[J]. 中华结直肠疾病电子杂志, 2021, 10(03): 302-305.
阅读次数
全文


摘要