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中华损伤与修复杂志(电子版) ›› 2024, Vol. 19 ›› Issue (04) : 277 -281. doi: 10.3877/cma.j.issn.1673-9450.2024.04.001

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重视烧伤创面愈合中的葡萄糖代谢以优化营养治疗策略
孙勇1, 彭曦2,()   
  1. 1. 221004 陆军第七十一集团军医院 徐州医科大学附属淮海医院烧伤整形外科
    2. 400038 重庆,陆军军医大学西南医院临床医学研究中心 全军烧伤研究所 创烧、烧伤与复合伤国家重点实验室
  • 收稿日期:2023-07-31 出版日期:2024-06-01
  • 通信作者: 彭曦
  • 基金资助:
    江苏省自然科学基金面上项目(BK20211060); 徐州医科大学附属淮海医院重点课题(YNZD-2022002)

Emphasis on optimizing nutritional treatment strategies of glucose metabolism in burn wound healing

Yong Sun1, Xi Peng2,()   

  1. 1. Department of Burns and Plastic Surgery, the 71st Group Army Hospital of PLA Army, Affiliated Huaihai Hospital of Xuzhou Medical University, Xuzhou 221004, China
    2. Clinical Medical Research Center, Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, the Southwest Hospital of Army Medical University, Chongqing 400038, China
  • Received:2023-07-31 Published:2024-06-01
  • Corresponding author: Xi Peng
引用本文:

孙勇, 彭曦. 重视烧伤创面愈合中的葡萄糖代谢以优化营养治疗策略[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(04): 277-281.

Yong Sun, Xi Peng. Emphasis on optimizing nutritional treatment strategies of glucose metabolism in burn wound healing[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2024, 19(04): 277-281.

皮肤烧伤后,机体通过炎症反应、细胞增殖和组织重塑对受损组织进行修复,恢复组织结构和功能的完整性,从而实现创面愈合。在此过程中,蛋白质合成代谢的作用一直备受关注,而葡萄糖的作用往往被忽视,甚至一度被认为是影响创面愈合的危险因素。因此,应重视对烧伤创面愈合不同阶段葡萄糖代谢特点、葡萄糖代谢对创面修复调控作用和烧伤患者葡萄糖供给策略的研究,以正确认识葡萄糖在烧伤创面修复中的作用,指导临床合理使用葡萄糖。

After skin burns, the body can repair the damaged tissue through inflammatory reaction, cell proliferation and tissue remodeling, and restore the structural and functional integrity of the tissue, so as to achieve wound healing. In this process, the role of protein anabolism has always been highly valued, while the role of glucose is often ignored and even considered as a risk factor affecting wound healing. Therefore, more attention should be paid to the study of the metabolic characteristics of glucose in different stages of burn wound healing, the regulatory effect of glucose metabolism on wound repair and the glucose supply strategy of burn patients, in order to have a correct understanding of the role of glucose in burn wound repair and guide the rational use of glucose in clinical practice.

[1]
孙勇,彭曦. 重视烧伤创面愈合中的蛋白质营养问题[J]. 肠外与肠内营养2022, 29(2):65-68.
[2]
彭曦,孙勇. 烧伤创面修复中的代谢问题及营养策略[J]. 中华烧伤与创面修复杂志2022, 38(8):707-713.
[3]
彭曦. 重症烧伤患者的代谢分期及营养治疗策略[J]. 中华烧伤杂志2021, 37(9):805-810.
[4]
Burgess M, Valdera F, Varon D, et al. The immune and regenerative response to burn injury[J]. Cells, 2022, 11(19):3073.
[5]
Orecchioni MGhosheh YPramod AB,et al. Macrophage polarization: different gene signatures in M1(LPS+) vs. classically and M2(LPS-) vs. alternatively activated macrophages[J].Front Immunol201910:1084.
[6]
Everts B, Amiel E, Huang SC, et al. TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKε supports the anabolic demands of dendritic cell activation[J].Nat Immunol201415(4):323-332.
[7]
Geeraerts X, Bolli E, Fendt SM, et al. Macrophage metabolism as therapeutic target for cancer, atherosclerosis, and obesity[J]. Front Immunol20178:289.
[8]
Bai Q, Gao Q, Hu F, et al. Reoxygenation modulates the adverse effects of hypoxia on wound repair[J]. Int J Mol Sci, 2022, 23(24):15832.
[9]
Hu Q, Lyon CJ, Fletcher JK, et al. Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses[J]. Acta Pharm Sin B, 202111(6):1493-1512.
[10]
Wu L, Zhang Q, Li Y, et al. Collagen sponge prolongs taurine release for improved wound healing through inflammation inhibition and proliferation stimulation[J]. Ann Transl Med, 2021, 9(12):1010.
[11]
Shpichka A, Butnaru D, Bezrukov EA, et al. Skin tissue regeneration for burn injury[J]. Stem Cell Res Ther, 2019, 10(1):94.
[12]
Singer AJ. Healing mechanisms in cutaneous wounds: tipping the balance[J]. Tissue Eng Part B Rev, 2022, 28(5):1151-1167.
[13]
Badoiu SC, Miricescu D, Stanescu-Spinu II, et al. Glucose metabolism in burns-What happens?[J]. Int J Mol Sci, 2021, 22(10): 5159.
[14]
Vinaik R, Barayan D, Auger C, et al. Regulation of glycolysis and the Warburg effect in wound healing[J]. JCI Insight, 2020, 5(17):e138949.
[15]
Cooper CR, Hess AL, Brianna H, et al. Tube feeding through surgery, impact on glucose control in burn patients[J]. J Burn Care Res, 2020 (Supple 1):S10-S11.
[16]
Huiting Y, Chan N, Yanna Z, et al. Tolerance to glucose and lipid high metabolic reactions after burns in an obese rat model[J]. J Burn Care Res, 202243(1):1-8.
[17]
Shahrokhi S, Jeschke MG. Metabolic and nutritional support[J]. Surg Clin North Am, 2023, 103(3):473-482.
[18]
Grossman H, Cole TJ, Shaw C, et al. Baseline glucose levels moderate the association between burn-related mortality inpatients with obesity[J]. Burns, 2023, 49(8):1893-1899.
[19]
韩春茂,张莉萍,吴攀. 从理论到实践浅论严重烧伤患者的精准营养支持[J]. 中华烧伤与创面修复杂志2022, 38(8):701-706.
[20]
Williams FN, Branski LK, Jeschke MG, et al. What, how, and how much should patients with burns be fed?[J]. Surg Clin North Am, 201191(3):609-629.
[21]
Stanojcic M, Abdullahi A, Rehou S, et al. Pathophysiological response to burn injury in adults[J]. Ann Surg, 2018, 267(3):576-584.
[22]
Hendrix HA, Velamuri SR, Sultan-Ali I, et al. Simplified approach to incorporating glycemic response within a continuous insulin infusion algorithm to improve the incidence of hypoglycemia in a single burn center[J]. J Burn Care Res, 2020, 41(4):791-795.
[23]
Yao RQ, Ren C, Wu GS, et al. Is intensive glucose control bad for critically ill patients? A systematic review and meta-analysis[J]. Int J Biol Sci, 2020, 16(9):1658-1675.
[24]
Yu T, Gao M, Yang P, et al. Insulin promotes macrophage phenotype transition through PI3K/Akt and PPAR-γ signaling during diabetic wound healing[J]. J Cell Physiol, 2019, 234(4):4217-4231.
[25]
Dolp R, Rehou S, Pinto R, et al. The effect of diabetes on burn patients: a retrospective cohort study[J]. Crit Care, 2019, 23(1):28.
[26]
Yang YJ, Su S, Zhang Y, et al. Effects of enteral nutrition with different energy supplies on metabolic changes and organ damage in burned rats[J]. Burns Trauma, 2022, 10:tkac042.
[27]
Yang Y, Su S, Zhang Y, et al. Effects of different ratios of carbohydrate-fat in enteral nutrition on metabolic pattern and organ damage in burned rats[J]. Nutrients, 2022, 14(17): 3653.
[28]
杨敏,韩春茂. 创面治疗中的循证营养干预[J]. 中华烧伤与创面修复杂志2022, 38(8):798.
[29]
彭曦. 我国烧伤营养的发展历程与未来方向[J]. 中华损伤与修复杂志(电子版), 2020, 15(5):331-336.
[30]
Hill DM, Lloyd S, Hickerson WL. Incidence of hypoglycemia in burn patients: a focus for process improvement[J]. Hosp Pharm, 2018, 53(2):121-124.
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