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中华损伤与修复杂志(电子版) ›› 2025, Vol. 20 ›› Issue (04) : 363 -367. doi: 10.3877/cma.j.issn.1673-9450.2025.04.015

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综述

糖尿病血管内皮细胞损伤机制的研究进展
奎玉凤, 李毅()   
  1. 810000 西宁,青海大学附属医院烧伤整形外科
  • 收稿日期:2025-03-27 出版日期:2025-08-01
  • 通信作者: 李毅
  • 基金资助:
    青海省“昆仑人才高端创新与创业人才”项目((2022)2024-0301- ZJC-0112)

Mechanism of endothelial cell injury in diabetes: a review

Yufeng Kui, Yi Li()   

  1. Department of Burn and Plastic Surgery,Affiliated Hospital of Qinghai University,Xining 810000,China
  • Received:2025-03-27 Published:2025-08-01
  • Corresponding author: Yi Li
引用本文:

奎玉凤, 李毅. 糖尿病血管内皮细胞损伤机制的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2025, 20(04): 363-367.

Yufeng Kui, Yi Li. Mechanism of endothelial cell injury in diabetes: a review[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2025, 20(04): 363-367.

糖尿病发病率呈持续上升趋势,糖尿病微血管病变引发的并发症发生率也随之升高,如糖尿病足、糖尿病慢性溃疡等。糖尿病慢性溃疡因治疗周期漫长,严重影响患者生活质量,其病变损伤机制在疾病进程中起关键作用。值得注意的是,血管内皮细胞(VECs)功能障碍作为血管并发症发生发展的核心环节,对其机制研究具有重要临床价值。因此,希望通过系统探讨VECs损伤的分子机制,为糖尿病慢性溃疡的治疗提供新型靶点与干预策略。

The prevalence of diabetes mellitus continues to exhibit a sustained upward trend, accompanied by a concurrent rise in the incidence of diabetic microvascular complications. Conditions such as diabetic foot and diabetic chronic ulcers have shown a marked increase in prevalence. Diabetic chronic ulcers, characterized by prolonged therapeutic duration, not only significantly impair patients' quality of life but also demonstrate crucial pathogenic mechanisms that play a pivotal role in disease progression. Notably, vascular endothelial cells (VECs) dysfunction serves as a central pathological event in the initiation and development of vascular complications, rendering the elucidation of its underlying mechanisms clinically significant. Therefore, hope to provide novel therapeutic targets and interventional strategies for diabetic chronic ulcers by exploring systematic investigation into the molecular mechanisms underlying VECs injury.

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