Clinical significance of correction of Th1/Th2 migration in the treatment of early renal injury in children with allergic purpura

doi:10.3877/cma.j.issn.1673-9450.2016.02.007

Abstract

Abstract:

Objective

To investigate and explore the clinical significance of Th1/Th2 in the early stage of renal injury in children with allergic purpura.

Methods

Fifty children with allergic purpura and early renal injury were selected as the research object, which was named as purpura nephritis group and treated with Th1/Th2 migration, while 50 children with allergic purpura were set to simple purpura group and 50 cases of healthy children were used as the control group in the same period. IL-4, IFN-γ, Th1 cells and Th2 cells were detected and the datas were compared.

Results

Before treatment, there was no significant difference in Th1, IFN-γ, Th2 and IL-4 between purpura nephritis group and simple purpura group (P>0.05), but the IFN-γ, Th1, Th1/Th2 of the two groups were significantly lower than those of control group (P<0.05), IL-4 and Th2 were significantly higher than those of control group (P<0.05). Compared with before treatment, the IFN-γ, Th1, Th1/Th2 of purpura nephritis group were significantly improved after treatment (P<0.05), IL-4 and Th2 were significantly decreased (P<0.05), and there was no significant difference compared with control group (P>0.05), and the content of urine protein in purpura nephritis group was significantly improved (P<0.05).

Conclusion

Th1/Th2 migration treatment can effectively correct the imbalance of Th1/Th2, Th1/Th2 can be used as an important indicator of the prognosis of children with allergic purpura and early renal damage.

Key words: Purpura, schoenlein-henoch, Th1 cells, Th2 cells, Renal damage

Zhansheng Wang, Yulu Liu, Xueying Shi, Guangxiu Hu, Daoyun Duan, Dong Wang, Lingyun Gao, Qian Tan. Clinical significance of correction of Th1/Th2 migration in the treatment of early renal injury in children with allergic purpura[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2016, 11(02): 113-116.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhssyxfzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1673-9450.2016.02.007

https://zhssyxfzz.cma-cmc.com.cn/EN/Y2016/V11/I02/113

Figures/Tables 1

References 18

[1]	陶红，李秋，王莉，等. 过敏性紫癜发病中树突状细胞与T辅助细胞分化失衡的关系[J]．第三军医大学学报，2010, 32(7): 677-679.
[2]	常红，张秋业，程娜，等. 过敏性紫癜患儿外周血单个核细胞TLR2、TLR4表达及其与Th1和Th2型免疫应答相关性观察[J]. 中华微生物学和免疫学杂志，2013, 33(11): 839-844.
[3]	訾广芹，付元，陈秀霞，等. 过敏性紫癜患儿外周血单个核细胞TLR6表达及其与Th1、Th2和Th17细胞免疫应答相关性研究[J/CD]. 中华临床医师杂志：电子版，2014, 9(21): 3789-3794.
[4]	王烨. Th1/Th2迁移与血清IgA aCL在儿童过敏性紫癜病理机制中的作用[D]. 石家庄：河北医科大学，2012.
[5]	王竹，郑利雄，黄炳坤. 体外阻断CD134对过敏性紫癜患者外周血单个核细胞TH1和TH2细胞因子表达的影响[J]. 检验医学与临床，2011, 8(4): 434-435.
[6]	程小丽，陈葳，杨玉琮，等. 过敏性紫癜患儿T细胞亚群及体液免疫功能的分析[J]. 现代检验医学杂志，2012, 27(4): 50-52.
[7]	李燕林，王永清，朱迪卿，等. 过敏性紫癜患儿急性期细胞免疫功能变化及临床意义[J]．中国血液流变学杂志，2014, 24(2): 290-291, 310.
[8]	唐雪梅. 过敏性紫癜病因及免疫发病机制[J]. 实用儿科临床杂志，2012, 27(21): 1634-1636.
[9]	程娜. 过敏性紫癜患儿外周血单核细胞TLR2表达及其与Th1和Th2型免疫应答相关性研究[D]. 青岛大学，2013.
[10]	Kawasaki Y, Suyama K, Hashimoto K, et al. Methylprednisolone pulse plus mizoribine in children with Henoch-Schoenlein purpura nephritis [J]. Clin Rheumatol, 2011, 30(4): 529-535.
[11]	Alioglu B, Ozsoy MH, Tapci E, et al. Successful use of recombinant factor VIIa in a child with Schoenlein-Henoch purpura presenting with compartment syndrome and severe factor XIII deficiency[J]. Blood Coagul Fibrinolysis, 2013, 24(1): 102-105.
[12]	杨帆，张海玉，张影，等. 低分子肝素钙对儿童过敏性紫癜肾早期损害的治疗效果评价[J]. 吉林大学学报(医学版), 2012, 38(1): 155-158.
[13]	杨军霞. 微量低分子肝素和维生素E预防过敏性紫癜肾损害疗效观察[J]. 中国中西医结合儿科学，2010, 2(4): 338-340.
[14]	Park SJ, Kim JH, Shin JI. Is there a link between the use of etanercept and Henoch-Sch nlein purpura Comment on: Henoch-Schonlein purpura in a patient with the rheumatoid arthritis receiving etanercept (Eur J Dermatol 2010; 20: 521-2)[J]. Eur J Dermatol, 2011, 21(1): 147.
[15]	Boulis E, Majithia V, McMurray R. Adult-onset Henoch-Schonlein purpura with positive c-ANCA (anti-proteinase 3): case report and review of literature[J]. Rheumatol Int, 2013, 33(2): 493-496.
[16]	Liu H, Ouyang X, Li Y, et al. Involvement of levels of Toll like receptor-4 in monocytes, CD4^＋ T-lymphocyte subsets, and cytokines in patients with immune thrombocytopenic purpura[J]. Thromb Res, 2013, 132(2): 196-201.
[17]	Zhao H, Du W, Wang D, et al. The expression of IFN-gamma, IL-4, Foxp3 and perforin genes are not correlated with DNA methylation status in patients with immune thrombocytopenic purpura[J]. Platelets, 2010, 21(2): 137-143.
[18]	卢晓芳，冯尚克. 低分子肝素钙治疗儿童过敏性紫癜及对肾的保护作用[J]. 广西医学，2013, 35(9): 1235-1236.

组别		IL-4 (pg/mL)	IFN-γ(pg/mL)	Th1(%)	Th2(%)	Th1/Th2(%)
紫癜性肾炎组		?	?	?	?	?
?	治疗前	59.17±23.72	33.25±9.10	10.14±0.23	2.64±0.43	3.87±0.48
?	治疗后	20.31±11.07^a	49.68±12.54^a	11.09±0.64^a	1.79±0.31^a	6.19±0.56^a
单纯紫癜组		57.50±22.93^b	34.71±9.77^b	10.17±0.58^b	2.57±0.48^b	4.01±0.57^b
对照组		19.25±8.11	50.25±13.14	11.13±0.69	1.80±0.22	6.26±0.83
t₁值		15.354	12.274	9.516	4.879	6.057
P₁值		0.0451	0.0367	0.0528	0.0254	0.0374
t₂值		13.254	11.025	8.241	5.662	7.214
P₂值		0.0354	0.0547	0.0367	0.0329	0.0263

组别		IL-4 (pg/mL)	IFN-γ(pg/mL)	Th1(%)	Th2(%)	Th1/Th2(%)
紫癜性肾炎组		?	?	?	?	?
?	治疗前	59.17±23.72	33.25±9.10	10.14±0.23	2.64±0.43	3.87±0.48
?	治疗后	20.31±11.07^a	49.68±12.54^a	11.09±0.64^a	1.79±0.31^a	6.19±0.56^a
单纯紫癜组		57.50±22.93^b	34.71±9.77^b	10.17±0.58^b	2.57±0.48^b	4.01±0.57^b
对照组		19.25±8.11	50.25±13.14	11.13±0.69	1.80±0.22	6.26±0.83
t₁值		15.354	12.274	9.516	4.879	6.057
P₁值		0.0451	0.0367	0.0528	0.0254	0.0374
t₂值		13.254	11.025	8.241	5.662	7.214
P₂值		0.0354	0.0547	0.0367	0.0329	0.0263

Please choose a citation manager

Content to export