Related research of bone marrow stromal cells and secondary stage repair of spinal cord injury

doi:10.3877/cma.j.issn.1673-9450.2017.07.012

Abstract

Abstract:

With the understanding of the mechanism of spinal cord injury, spinal cord damage scope and degree of secondary phase is greater than the primary stage, the latter is irreversible original damage, while the former is secondary, reversible and can control the biochemical reaction process, through bone marrow mesenchymal stem cell transplantation for spinal cord injury between secondary stage intervention treatment, as the theoretical basis for clinical accurate treatment of spinal cord injury.In this paper, regarding the pathophysiological changes of spinal cord injury secondary stage, between bone marrow mesenchymal stem cells in treatment of spinal cord injury potential ability and the present stage combined treatment results were introduced simply.

Key words: Spinal cord injuries, Bone marrow, Mesenchymal stem cell transplantation, Secondary injury, Spinal cord repair

Xinming Yang. Related research of bone marrow stromal cells and secondary stage repair of spinal cord injury[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2017, 12(01): 65-68.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhssyxfzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1673-9450.2017.07.012

https://zhssyxfzz.cma-cmc.com.cn/EN/Y2017/V12/I01/65

References 31

1	王海波，杨新明，张瑛，等. 骨髓间充质干细胞移植治疗脊髓损伤的研究进展[J]. 生物骨科材料与临床研究，2012, 9(5): 16-19.
2	Yip PK, Malaspina A. Spinal cord trauma and the molecular point of no return[J]. Mol Neurodegener, 2012, 7: 6.
3	Kumagai G, Tsoulfas P, Toh S, et al. Genetically modified mesenchymal stem cells (MSCs) promote axonal regeneration and prevent hypersensitivity after spinal cord injury[J]. Exp Neurol, 2013, 248: 369-380.
4	Vicente Ballesteros Plaza, Bartolomé Marré Pacheco, Celmira Martínez Aguilar, et al. Lesión de la médula espinal: actualización bibliográfica: fisiopatología y tratamiento inicial/ Lesão de medula espinal: atualização da literatura: fisiopatologia e tratamento inicial/ Spinal cord injury: literature update: physiopathology and initial treatment[J]. Coluna/Columna, 2012, 11(1): SciELO.
5	Jaerve A, Müller HW. Chemokines in CNS injury and repair[J]. Cell Tissue Res, 2012, 349(1): 229-248.
6	Jin Y, Bouyer J, Shumsky JS, et al. Transplantation of neural progenitor cells in chronic spinal cord injury[J]. Neuroscience, 2016, 320: 69-82.
7	Oyinbo CA. Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade[J]. Acta Neurobiol Exp (Wars), 2011, 71(2): 281-299.
8	Kwon BK, Fisher CG, Dvorak MF, et al. Strategies to promote neural repair and regeneration after spinal cord injury[J]. Spine (Phila Pa 1976), 2005, 30(17 Suppl): S3-S13.
9	Inoue M, Honmou O, Oka S, et al. Comparative analysis of remyelinating potential of focal and intravenous administration of autologous bone marrow cells into the rat demyelinated spinal cord[J]. Glia, 2003, 44(2): 111-118.
10	Karamouzian S, Nematollahi-Mahani SN, Nakhaee N, et al. Clinical safety and primary efficacy of bone marrow mesenchymal cell transplantation in subacute spinal cord injured patients[J]. Clin Neurol Neurosurg, 2012, 114(7): 935-939.
11	Woodbury D, Schwarz EJ, Prockop DJ, et al. Adult rat and human bone marrow stromal cells differentiate into neurons[J]. J Neurosci Res, 2000, 61(4): 364-370.
12	Kang ES, Ha KY, Kim YH. Fate of transplanted bone marrow derived mesenchymal stem cells following spinal cord injury in rats by transplantation routes[J]. J Korean Med Sci, 2012, 27(6): 586-593.
13	Tetzlaff W, Okon EB, Karimi Abdolrezaee S, et al. A systematic review of cellular transplantation therapies for spinal cord injury[J]. J Neurotrauma, 2011, 28(8): 1611-1682.
14	Uccelli A, Benvenuto F, Laroni A, et al. Neuroprotective features of mesenchymal stem cells[J]. Best Pract Res Clin Haematol, 2011, 24(1): 59-64.
15	Ide C, Nakai Y, Nakano N, et al. Bone marrow stromal cell transplantation for treatment of sub- acute spinal cord injury in the rat[J]. Brain Res, 2010, 1332: 32-47.
16	Richner M, Ulrichsen M, Elmegaard SL, et al. Peripheral nerve injury modulates neurotrophin signaling in the peripheral and central nervous system[J]. Mol Neurobiol, 2014, 50(3): 945-970.
17	Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement[J]. Cytotherapy, 2006, 8(4): 315-317.
18	Hawryluk GW, Mothe A, Wang J, et al. An in vivo characterization of trophic factor production following neural precursor cell or bone marrow stromal cell transplantation for spinal cord injury[J]. Stem Cells Dev, 2012, 21(12): 2222-2238.
19	Zhang YJ, Zhang W, Lin CG, et al. Neurotrophin-3 gene modified mesenchymal stem cells promote remyelination and functional recovery in the demyelinated spinal cord of rats[J]. J Neurol Sci, 2012, 313(1/2): 64-74.
20	Cavus G, Altas M, Aras M, et al. Effects of montelukast and methylprednisolone on experimental spinal cord injury in rats[J]. Eur Rev Med Pharmacol Sci, 2014, 18(12): 1770-1777.
21	Nakajima H, Uchida K, Guerrero AR, et al. Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury[J]. J Neurotrauma, 2012, 29(8): 1614-1625.
22	Lehnardt S. Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury[J]. Glia, 20l0, 58(3): 253-263.
23	Hofstetter CP, Schwarz EJ, Hess D, et al. Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery[J]. Proc Natl Acad Sci U S A, 2002, 99(4): 2199-2204.
24	Akiyama Y, Radtke C, Honmou O, et al. Remyelination of the spinal cord following intravenous delivery of bone marrow cells[J]. Glia, 2002, 39(3): 229-236.
25	Isele NB, Lee HS, Landshamer S, et al. Bone marrow stromal cells mediate protection through stimulation of PI3-K/Akt and MAPK signaling in neurons[J]. Neurochem Int, 2007, 50(1): 243-250.
26	Tondreau T, Meuleman N, Stamatopoulos B, et al. In vitro study of matrix metalloproteinase/tissue inhibitor of metalloproteinase production by mesenchymal stromal cells in response to inflammatory cytokines: the role of their migration in injured tissues[J]. Cytotherapy, 2009, 11(5): 559-569.
27	Wang LJ, Zhang RP, Li JD. Transplantation of neurotrophin-3-expressing bone mesenchymal stem cells improves recovery in a rat model of spinal cord injury[J]. Acta Neurochir (Wien), 2014, 156(7): 1409-1418.
28	Lin WW, Li M, Li Y, et al. Bone marrow stromal cells promote neurite outgrowth of spinal motor neurons by means of neurotrophic factors in vitro[J]. Neurol Sci, 2014, 25(3): 449-457.
29	Chen L, Cui X, Wu Z, et al. Transplantation of bone marrow mesenchymal stem cells pretreated with valproic acid in rats with an acute spinal cord injury[J]. Biosci Trends, 2014, 8(2): 111-119.
30	Jin W, Wang J, Zhu T, et al. Anti-inflammatory effects of curcumin in experimental spinal cord injury in rats[J]. Inflamm Res, 2014, 63(5): 381-387.
31	Guerrero AR, Uchida K, Nakajima H, et al. Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice[J]. J Neuroinflammation, 2012, 9: 40.

[1]	Jiwei Zhao, Zhifen Zeng, Honghua Zeng, Meng Zhang, Lingling Li, Zhijie He, Yaowei Zhi. Cytological characteristics of bone marrow in adult patients with sepsis [J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2022, 15(01): 14-21.
[2]	Luyue Ding, Wei Liu, Ang Wei, Ruidong Zhang, Tianyou Wang, Linlin Liu, Buolun Zang, Yafeng Wang, Xianliang Wang. Clinical observation of blinatumomabin in the treatment of children with relapsed/refractory CD19-positive B-cell acute lymphoblastic leukemia [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(02): 194-201.
[3]	Xiuzhang Yu, Mingrong Qie, Minmin Hou. Current research status of endometriosis and stem cells [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2021, 17(02): 132-137.
[4]	Yong Li, Yong Quan, Shiyan Fu, Xinze Ran, Hong Tang, Suiyi Liu, Jie Li, Chang Shu, Yonglai Chen, Jing Zhang, Bingbing Yang, Yuhui Hao. Influence of hypoxia on acute radiation injuries in mice [J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2023, 18(04): 299-305.
[5]	Chao Xing, Lingqiao Xu, Wenting Liao, Yangpeng Sun, Zhongtai Ye, Zhiguang Zhang. Condyle chondrocytes regeneration promoted by exosomes from bone marrow mesenchymal stem cells [J]. Chinese Journal of Stomatological Research(Electronic Edition), 2021, 15(04): 207-214.
[6]	Lu Zhao, Zheru Zhang, Junqi Jia, Chunlin Zong, Li Jing, Kai Guo, Lei Tian. The experimental study of M2 macrophages inhibiting the transformation of bone marrow mesenchymal stem cells into myofibroblasts after radiation [J]. Chinese Journal of Stomatological Research(Electronic Edition), 2021, 15(04): 198-206.
[7]	Yanqun Zhou, Peng Chen, Zenghui Liu, Jingjing Mao, Yaohe Li. Screening and verifying key genes and signal pathways involved in senescence of bone marrow mesenchymal stem cells in patients with multiple myeloma based on bioinformatics analysis [J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2022, 12(05): 274-281.
[8]	Yidong Liu, Yufeng Jia, Yan Wang, Yang Liu, Jinyue Ning. Upregulation of Wnt-1 gene expression by soybean isoflavones to promote the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells [J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2021, 11(05): 292-297.
[9]	Yingming Li, Hua Chen, Yan Wu. The effects of K562 cell-derived exosomes on the hematopoietic and osteogenic gene expressions of bone marrow mesenchymal stem cells [J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2021, 11(04): 207-214.
[10]	Yuantong Zang, Litian Zhang, Meiying Yang, Xiaojuan Zhao, Li Li. A study on the effect of solution focused approach on the acceptance of disability in patients with spinal cord injury with paraplegia [J]. Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition), 2021, 07(02): 93-98.
[11]	Yun Huang, Jing Ming, Chenchen Gong, Xu Liu, Jianyu Fu, Hongying Bi, Hui Fang, Yan Tang, Yuanyi Liu, Difen Wang. Severe myelosuppression causescatheter related severe cavitary Staphylococcus aureus pneumonia [J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2021, 07(03): 282-284.
[12]	Yongsheng Meng, Rong Yong, Xiaoli Ji, Yulong Zhao, Pengfei Zhao. Preventive effect of dexmedetomidine combined with sevoflurane on secondary injury after intracerebral hemorrhage and its neuroprotective mechanism [J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2023, 13(01): 44-50.
[13]	Hui Yang, Lixiang Lu, Jian Yi, Xu Yi. Effects of BMSCs and Bunao No. 1 medicated serum on expression of ICAM-1 and NF200 in mouse hippocampal neurons with oxygen-glucose deprivation [J]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(01): 100-106.
[14]	Wei Zhang, Ya′nan Wei, Na Han. Bone marrow mesenchymal stem cell-derived exosomes promote peripheral nerve injury recovery [J]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(04): 265-271.
[15]	Chinese Orthopaedic Association, Junchao Xing, Long Bi, Li Chen, Shiwu Dong, Liangbin Gao, Tianyong Hou, Zhiyong Hou, Wei Huang, Huiyong Jin, Yan Li, Zhonghai Li, Peng Liu, Ximing Liu, Fei Luo, Feng Ma, Jie Shen, Jinlin Song, Peifu Tang, Xinbao Wu, Baoshan Xu, Jianzhong Xu, Yongqing Xu, Bin Yan, Peng Yang, Qing Ye, Guoyong Yin, Tengbo Yu, Jiancheng Zeng, Changqing Zhang, Yingze Zhang, Zehua Zhang, Feng Zhao, Yue Zhou, Yun Zhu, Jun Zou. Expert consensus for the clinical application of autologous bone marrow enrichment technique for bone repair(version 2023) [J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2023, 09(03): 129-141.

Please choose a citation manager

Content to export