To study the efficacy of mupirocin ointment and recombinant bovine basic fibroblast growth factor(rb-bFGF)in the treatment of the infectious wounds combined with free skin graft.

One hundred and sixty patients underwent closed infectious wound surgery for split-thickness skin in the Chongqing Three Gorges Central Hospital from March 2014 to March 2016 were randomly divided into four groups, with 40 cases in each group.(1)The vaseline gauze group, use the free skin grafts covered in the surface of the infectious wounds, and fixed with saline bandage.(2)The mupirocin ointment group, the wound of group was swabbed with mupirocin ointment and the skin graft field was fixed with bandages soaked with mupirocin ointment.(3)The rb-bFGF group, the wound of group was swabbed with rb-bFGF and covered with free skin graft, fixed with bandages soaked with rb-bFGF.(4)The mixture of rb-bFGF and mupirocin ointment group, the wound of this group was swabbed with the mixture of mupirocin ointment and rb-bFGF, coverd with free skin graft, fixed with bandages soaked with rb-bFGF and mupirocin ointment.The dressing change 4 d, 8 d and 12 d after surgery was observed, and the skin graft survival rate, wound healing time, and bacterial clearance rate were evaluated.

The survival rate of skin graft in the rb-bFGF and mupirocin ointment group 4 days after surgery was (96.69±3.38)%, higher than the groups of the vaseline gauze(82.17±82.17) %, mupirocin ointment(92.09±4.91)% and rb-bFGF(93.22±4.61)%, the differences were statistically significant(t=12.570, 4.875, 3.850; with P values below 0.05). The bacterial clearance rate in the rb-bFGF and mupirocin ointment group 4 days after surgrey was 87.50%(5/40), close to the groups of mupirocin ointment 85.00%(6/40)(χ²=0.11, P=0.745), higher than the groups of the vaseline gauze and rb-bFGF, 40.00%(24/40)(χ²=19.53, P<0.05)and 47.50%(21/40)(χ²=14.59, P<0.05). The bacterial clearance rate in the rb-bFGF and mupirocin ointment group 8 days after surgrey was 92.50%(3/40), close to the groups of mupirocin ointment 95.00%(2/40)(χ²=0.21, P =0.640), higher than the groups of the vaseline gauze and rb-bFGF, 72.50%(11/40)(χ²=5.54, P=0.020)和75.00%(10/40)(χ²=4.50, P =0.030). The bacterial clearance rate in the rb-bFGF and mupirocin ointment group 10 days after surgrey was 100%(0/40), equal to the group of mupirocin ointment 100%(0/40), higher than the groups of the vaseline gauze and rb-bFGF, 95.00%(2/40)(χ²=2.05, P=0.150)and 92.50%(3/40)(χ²=3.12, P=0.080). The wound healing rate in the rb-bFGF and rb-bFGF and mupirocin ointment group 8 days after surgrey were 5.00%(2/40), 12.50%(5/40), the difference was statistically significant(χ²=18.24, P<0.05). Twelve days after surgery, vaseline gauze, mupirocin ointment, rb-bFGF, rb-bFGF and mupirocin ointment groups were 67.50%(27/40), 72.50%(29/40), 77.5%(31/40), 97.5%(39/40)(χ²=12.40, P=0.006). The wound healing time in the rb-bFGF and mupirocin ointment group after surgery was (10.45±1.58)d, shorter than the group of the vaseline gauze(13.30±2.45)d, the group of mupirocin ointment(12.57±1.87)d, and the groups of rb-bFGF(12.10±1.91)d, the differences were statistically significant (t=-6.175, -5.491, -4.211; with P values below 0.05).

The mixture of mupirocin ointment and rb-bFGF can improve the survival rate of wound infection with free skin graft, enhance local resistance to infection , and accelerate wound healing. The respective clinical efficacy was not significantly reduced.