To investigate the independent relationship between preoperative statin therapy and postoperative sternal wound infection major cardiovascular and cerebrovascular adverse events in patients undergoing coronary artery bypass grafting(CABG).

A toal of 880 patients undergoing CABG were enrolled from January 1, 2019 to December 31, 2019 in Beijing Anzhen Hospital, Capital Medical University. Five hundred and three patients (57.2%) who received statins before CABG were assigned to the experimental group. The remaining 377 patients were not treated with statins before surgery and were set as the control group. The incidence of sternal incision infection and major cardiovascular and cerebrovascular adverse events in the experimental group and the control group were compared, and the corresponding risk factors were analyzed. Data were compared with chi-square test, single factor analysis of variance and multivariate logistic regression analysis.

The incidence of sternal incision infection and the incidence of major cardiovascular and cerebrovascular adverse events were 2.0% and 27.6%, respectively, compared with the experimental group (5.6% and 35.0%), the differences were statistically significant (χ²=0.869, 0.298; P=0.005, 0.022). Specifically, preoperative statin therapy independently reduced the incidence of sternal wound infection after CABG (OR 0.34, 95%CI 0.16-0.74; P=0.006) and major cardiovascular and cerebrovascular adverse events (OR 0.60, 95% CI 0.44-0.91; P=0.001).

Preoperative statin therapy is effective in deep sternal wound infection and major cardiovascular events among high-risk patients undergoing CABG.