Research progress of the influence mechanism of ω-3 polyunsaturated fatty acid on acute lung injury in inflammatory response and immune function

doi:10.3877/cma.j.issn.1673-9450.2020.03.014

Abstract

Abstract:

In the process of diseases such as burns (trauma), inhalation injury, severe infection and shock, the release of a variety of inflammatory mediators in the body triggers the migration of inflammatory cells to lung tissue and activate an inflammatory reaction with cascade amplification, which often cause acute lung injury (ALI) mainly with damage to pulmonary capillary endothelial cells and alveolar epithelial cells. Severe cases can rapidly develop into acute respiratory distress syndrome (ARDS) in a short period of time with extremely high fatality rate. ω-3 polyunsaturated fatty acid (ω-3PUFA), as an important component of pharmacological immune nutrients, has now gone beyond the previous category of simply providing energy and restoring positive nitrogen balance. It plays a comprehensive role in regulating inflammation, immune function, and gradually evolves into an important component of modern critically ill lung injury treatment. Therefore, this article reviews the mechanism and anti-inflammatory mechanism of ω-3PUFA on ALI inflammatory response and immune function, aiming to provide theoretical basis for clinical treatment of ALI.

Key words: Fatty acids, unsaturated, Acute lung injury, Immunity, ω-3polyunsaturated fatty acids, Mechanism

Xincheng Liao, Guanghua Guo. Research progress of the influence mechanism of ω-3 polyunsaturated fatty acid on acute lung injury in inflammatory response and immune function[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2020, 15(03): 219-222.

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