Research progress of pyruvate on hypoxic injury of important organs

doi:10.3877/cma.j.issn.1673-9450.2020.06.014

Abstract

Abstract:

Pyruvate, as an intermediate metabolite of glycolysis, has a wide range of biological, pharmacological and clinical value.A large number of animal studies have shown that sodium pyruvate can reduce mitochondrial damage, anti-inflammatory, anti-oxidation, inhibit cell apoptosis and correct lactic acid acidosis in the pathophysiological process of hypoxic injury caused by various reasons, so as to protect the brain, kidney, digestive tract and other important organ functions.In this paper, the above effects of pyruvate and its possible mechanism were briefly reviewed, and the application value of pyruvate in drug resuscitation of various major wars and trauma was prospected.

Key words: Pyruvates, Hypoxic injury, Recovery

Lili Geng, Guoyong Zhou, Juan Li, Huxian Liu, Ke Sun, Yonghua Sun, Ding Zeng. Research progress of pyruvate on hypoxic injury of important organs[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2020, 15(06): 499-501.

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https://zhssyxfzz.cma-cmc.com.cn/EN/Y2020/V15/I06/499

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