Research progress on the senescence of epidermis and epidermal stem cells

doi:10.3877/cma.j.issn.1673-9450.2022.06.012

Abstract

Abstract:

Located in the outermost layer of the body, epidermis is the first barrier to protect the body from external harmful substances. Mainly distributed in the basal layer of the epidermis, epidermal stem cells are seed cells whose proliferation, differentiation and apoptosis are closely related to the maintenance of epidermal homeostasis and damage repair. The senescence-related changes of epidermal structure, function, cell composition and damage repair ability have been introduced by reviewing the researches. Also the senescence-related changes of division, proliferation, differentiation and apoptosis of epidermal stem cells have been summarized. The analysis shows that the changes of cell composition and cell functional status in the epidermis are closely related to the senescence of epidermis, and these are expected to become a treatment target for reversing skin aging.

Key words: Epidermis, Aging, Cell proliferation, Apoptosis

Jiachen Sun, Yaoyao Song, Chuanan Shen, Hongqing Zhao, Tianjun Sun. Research progress on the senescence of epidermis and epidermal stem cells[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2022, 17(06): 531-534.

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