Advances in animal experiment studies on mesenchymal stem cells for the treatment of inhalation injury

doi:10.3877/cma.j.issn.1673-9450.2023.02.015

Abstract

Abstract:

Inhalation injury is one of the three major causes of death in burns, which damages the respiratory tract or pulmonary parenchyma by heat or chemical irritants carried into the airways during respiration. The mortality of inhalation injury is high, however there is no specific and effective methods of clinical treatment. Mesenchymal stem cells have the functions of homing, promoting proliferation, anti-apoptosis, autocrine and paracrine, anti-inflammatory and immunomodulatory effects. This article reviews a large number of animal experimental studies on the treatment of inhalation injury with mesenchymal stem cells from different sources, which shows that mesenchymal stem cells can attenuate inhalation injury and improve the effectiveness of treatments and the prognosis of disease in various ways. Thus, the cell therapy with mesenchymal stem cells is an available option with promising prospects of clinical application.

Key words: Mesenchymal stem cells, Smoke inhalation injury, Acute lung injury, Animal experimentation, Cell- and tissue-based therapy

Zong Shen, Chenru Wei, Banghui Zhu, Yulu Bao, Guosheng Wu, Yu Sun. Advances in animal experiment studies on mesenchymal stem cells for the treatment of inhalation injury[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2023, 18(02): 180-183.

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References 38

[1]	Herndon DN. Total Burn Care，5/E[M]. Fifth. Singapore: elsevier, 2018: 174-183.
[2]	Galeiras R, Seoane-Quiroga L, Pertega-Diaz S. Prevalence and prognostic impact of inhalation injury among burn patients: a systematic review and meta-analysis[J]. J Trauma Acute Care Surg, 2020, 88(2): 330-344.
[3]	程文凤. 中国烧伤流行病学研究现状及多中心大面积烧伤患者流行病学调查分析[D]. 北京：中国人民解放军医学院，2017: 33.
[4]	豆哲，张国安. 系统综述我国烧伤患者吸入性损伤的流行病学特征[J]. 中华烧伤杂志，2021, 37(7): 7.
[5]	Jones SW, Williams FN, Cairns BA, et al. Inhalation injury: pathophysiology, diagnosis, and treatment[J]. Clin Plast Surg, 2017, 44(3): 505-511.
[6]	Holley AD, Reade MC, Lipman J, et al. There is no fire without smoke! Pathophysiology and treatment of inhalational injury in burns: a narrative review[J]. Anaesth Intensive Care, 2020, 48(2): 114-122.
[7]	Mercel A, Tsihlis ND, Maile R, et al. Emerging therapies for smoke inhalation injury: a review[J]. J Transl Med, 2020, 18(1): 141.
[8]	Farkhad NK, Mahmoudi A, Mahdipour E. How similar are human mesenchymal stem cells derived from different origins? A Review of comparative Studies[J]. Curr Stem Cell Res Ther, 2021, 16(8): 980-993.
[9]	L P K, Kandoi S, Misra R, et al. The mesenchymal stem cell secretome: a new paradigm towards cell-free therapeutic mode in regenerative medicine[J]. Cytokine Growth Factor Rev, 2019, 46: 1-9.
[10]	Abreu SC, Antunes MA, Xisto DG, et al. Bone marrow, adipose, and lung tissue-derived murine mesenchymal stromal cells release different mediators and differentially affect airway and lung parenchyma in experimental asthma[J]. Stem Cells Transl Med, 2017, 6(6): 1557-1567.
[11]	Yip HK, Fang WF, Li YC, et al. Human umbilical cord-derived mesenchymal stem cells for acute respiratory distress syndrome[J]. Crit Care Med, 2020, 48(5): e391-e399.
[12]	Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement[J]. Cytotherapy, 2006, 8(4): 315-317.
[13]	Matheakakis A, Batsali A, Papadaki HA, et al. Therapeutic implications of mesenchymal stromal cells and their extracellular vesicles in autoimmune diseases: from biology to clinical applications[J]. Int J Mol Sci, 2021, 22(18): 10132.
[14]	Najar M, Melki R, Khalife F, et al. Therapeutic mesenchymal stem/stromal cells: value, challenges and optimization[J]. Front Cell Dev Biol, 2021, 9: 716853.
[15]	Naji A, Eitoku M, Favier B, et al. Biological functions of mesenchymal stem cells and clinical implications[J]. Cell Mol Life Sci, 2019, 76(17): 3323-3348.
[16]	Kabat M, Bobkov I, Kumar S, et al. Trends in mesenchymal stem cell clinical trials 2004-2018: is efficacy optimal in a narrow dose range？[J]. Stem Cells Transl Med, 2020, 9(1): 17-27.
[17]	Purwaningrum M, Jamilah NS, Purbantoro SD, et al. Comparative characteristic study from bone marrow-derived mesenchymal stem cells[J]. J Vet Sci, 2021, 22(6): e74.
[18]	Liang Y, Yin C, Lu XI, et al. Bone marrow mesenchymal stem cells protect lungs from smoke inhalation injury by differentiating into alveolar epithelial cells via Notch signaling[J]. J Biosci, 2019, 44(1): 2.
[19]	金朝远，戴清霞，周芳庆，等. 热休克蛋白60对间充质干细胞在光气急性肺损伤中的影响[J]. 中华劳动卫生职业病杂志，2021, 39(2): 4.
[20]	Jin C, Zhou F, Zhang L, et al. Overexpression of heat shock protein 70 enhanced mesenchymal stem cell treatment efficacy in phosgene-induced acute lung injury[J]. J Biochem Mol Toxicol, 2020, 34(8): e22515.
[21]	Shao Y, Shen J, Zhou F, et al. Mesenchymal stem cells overexpressing Ang1 attenuates phosgene-induced acute lung injury in rats[J]. Inhal Toxicol, 2018, 30(7/8): 313-320.
[22]	刘名倬，王俊杰，付忠华，等. 沉默非肌肉肌球蛋白ⅡA的骨髓间充质干细胞对烟雾吸入性损伤大鼠早期肺损伤的影响[J]. 中华烧伤杂志，2017, 12(33): 766-771.
[23]	Sharma S, Muthu S, Jeyaraman M, et al. Translational products of adipose tissue-derived mesenchymal stem cells: bench to bedside applications[J]. World J Stem Cells, 2021, 13(10): 1360-1381.
[24]	Ihara K, Fukuda S, Enkhtaivan B, et al. Adipose-derived stem cells attenuate pulmonary microvascular hyperpermeability after smoke inhalation[J]. PLoS One, 2017, 12(10): e0185937.
[25]	Gao J, Yuan J, Liu Q, et al. Adipose-derived stem cells therapy effectively attenuates PM2.5-induced lung injury[J]. Stem Cell Res Ther, 2021, 12(1): 355.
[26]	陈尚雅，邵华，韩茹，等. 脂肪间充质干细胞对染矽尘大鼠肺损伤修复的研究[J]. 中华劳动卫生职业病杂志，2019, 37(1): 6.
[27]	Chen S, Cui G, Peng C, et al. Transplantation of adipose-derived mesenchymal stem cells attenuates pulmonary fibrosis of silicosis via anti-inflammatory and anti-apoptosis effects in rats[J]. Stem Cell Res Ther, 2018, 9(1): 110.
[28]	Xie Q, Liu R, Jiang J, et al. What is the impact of human umbilical cord mesenchymal stem cell transplantation on clinical treatment？[J]. Stem Cell Res Ther, 2020, 11(1): 519.
[29]	Hong SY, Teng SW, Lin W, et al. Allogeneic human umbilical cord-derived mesenchymal stem cells reduce lipopolysaccharide-induced inflammation and acute lung injury[J]. Am J Transl Res, 2020, 12(10): 6740-6750.
[30]	Tu C, Wang Z, Xiang E, et al. Human umbilical cord mesenchymal stem cells promote macrophage PD-L1 expression and attenuate acute lung injury in mice[J]. Curr Stem Cell Res Ther, 2022, 17(6): 564-575.
[31]	Zhu H, Xiong Y, Xia Y, et al. Therapeutic effects of human umbilical cord-derived mesenchymal stem cells in acute lung iInjury mice[J]. Sci Rep, 2017, 7: 39889.
[32]	Wang Y, Li H, Li X, et al. Hypoxic preconditioning of human umbilical cord mesenchymal stem cells is an effective strategy for treating acute lung injury[J]. Stem Cells Dev, 2021, 30(3): 128-134.
[33]	Liu QW, Huang QM, Wu HY, et al. Characteristics and therapeutic potential of human amnion-derived stem cells[J]. Int J Mol Sci, 2021, 22(2): 970.
[34]	Cui P, Xin H, Yao Y, et al. Human amnion-derived mesenchymal stem cells alleviate lung injury induced by white smoke inhalation in rats[J]. Stem Cell Res Ther, 2018, 9(1): 101.
[35]	Zhang S, Jiang W, Ma L, et al. Nrf2 transfection enhances the efficacy of human amniotic mesenchymal stem cells to repair lung injury induced by lipopolysaccharide[J]. J Cell Biochem, 2018, 119(2): 1627-1636.
[36]	Chen L, Qu J, Xiang C. The multi-functional roles of menstrual blood-derived stem cells in regenerative medicine[J]. Stem Cell Res Ther, 2019, 10(1): 1.
[37]	Ren H, Zhang Q, Wang J, et al. Comparative effects of umbilical cord- and menstrual blood-derived MSCs in repairing acute lung injury[J]. Stem Cells Int, 2018, 2018: 7873625.
[38]	Xiang B, Chen L, Wang X, et al. Transplantation of menstrual blood-derived mesenchymal stem cells promotes the repair of LPS-induced acute lung injury[J]. Int J Mol Sci, 2017, 18(4): 689.

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