Role of subcellular localization of YAP protein in the development of keloids

doi:10.3877/cma.j.issn.1673-9450.2024.02.016

Abstract

Abstract:

Keloids are formed mainly due to abnormal fibrosis during skin repair, which breaks the balance of extracellular matrix synthesis and degradation, and causes excessive deposition of extracellular collagen. At present, the treatment of keloids is mainly based on comprehensive treatment including surgical resection, local injection, laser and radiotherapy, but there is still a high recurrence rate. Exploring the molecular mechanism of keloid occurrence and development is of great significance for the clinical treatment of keloids. Hippo pathway may be one of the important pathways that cause keloids. The subcellular localization of YAP protein as a transcriptional regulator downstream of the Hippo pathway is related to the occurrence and development of keloids. In this article, the role and mechanism of the Hippo pathway during the occurrence of keloids were reviewed in order to provide some theoretical support for the treatment of keloids.

Key words: Hippo pathway, YAP protein, Subcellular localization, Keloid, Fibrosis

Xiangpeng Su, Xiao Wang, Jixun Zhang, Chao Wang, Xinxin Dong, Yongjun Qi, Zhenzhong Liu. Role of subcellular localization of YAP protein in the development of keloids[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2024, 19(02): 180-183.

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