Observation on the efficacy of collagenase ointment combined with hydrogel dressing in the treatment of deep partial-thickness burn wounds

doi:10.3877/cma.j.issn.1673-9450.2024.06.011

Abstract

Abstract:

Objective

To evaluate the clinical efficacy of collagenase ointment combined with hydrogel dressing in the treatment of deep partial-thickness burn wounds.

Methods

A total of 66 patients with deep partial-thickness burn wounds were admitted to Department of Burns， Tongren Hospital of Wuhan University & Wuhan Third Hospital from January 2022 to June 2023 who met the inclusion and exclusion criteria were enrolled as the study subjects.The patients were divided into observation group and control group according to random number table，with 33 patients in each group.The patients in the observation group received collagenase ointment combined with hydrogel dressing treatment， while the patients in the control group received iodine tincture vaseline gauze dressing treatment.The wound healing time， wound infection rate， necrotic tissue clearance rate， pain score， and modified Vancouver scar scale （mVSS） scores at 3 months and 12 months after treatment were recorded for both groups.

Results

The wound healing time in the observation group and the control group was （12.09±1.75）d and （12.97±1.88）d respectively， with no statistically significant difference （t=1.935， P=0.057）.No significant difference was found in wound infection rate between the two groups ［9.09%（3/33） vs 6.06%（2/33），P=1.000］.From day 5 to day 7 post-treatment，the necrotic tissue debridement rate in the observation group was （73.91±17.52）%， statistically higher than（58.91±13.30）% of the control group （t=3.916， P＜0.001）.From day 5 to day 7 post-treatment， the mVAS score during changing dressings was 1.94±1.17 in the observation group and 2.68±1.03 in the control group， with statistically significant difference （t= 3.475， P= 0.001）.At 3 months post-treatment， the thickness score on the mVSS scale in the observation group was 1.54±0.60， lower than 1.93±0.63 in the control group （t=2.198， P=0.032）， and the total mVSS score in the observation group was 8.73±1.71，lower than 9.85±1.65 in the control group， which was statistically different between the two groups（t=2.666，P=0.010）.At 12 months post-treatment， the total mVSS score in the observation group was 3.67±1.39， lower than 4.38±1.39 in the control group， with statistically significant difference （t=2.181， P=0.047）.There was no significant difference in sub-item scores of mVSS between the two groups（P＞0.05）.

Conclusion

The application of collagenase ointment combined with hydrogel dressing has good clinical efficacy in the treatment of deep partial-thickness burn wounds.It can effectively alleviate wound pain， reduce necrotic tissue， and inhibit scar hypertrophy.

Key words: Enzymatic debridement, Collagenase ointment, Hydrogel dressing, Deep partialthickness burns

Ling Peng, Hong Wu, Shiyong Wan, Lan Chen, Ziqing Ye, Jing Zhou. Observation on the efficacy of collagenase ointment combined with hydrogel dressing in the treatment of deep partial-thickness burn wounds[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2024, 19(06): 511-516.

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URL: https://zhssyxfzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1673-9450.2024.06.011

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Figures/Tables 8

组别	例数	性别（例）		年龄[岁，M(P₂₅,P₇₅)]	体质量指数（kg/m², $\bar{x}$ ±s）	烧伤原因（例）		烧伤部位（例）		烧伤面积[%TBSA，M(P₂₅,P₇₅)]	换药面积[cm²，M(P₂₅,P₇₅)]
组别	例数	男	女	年龄[岁，M(P₂₅,P₇₅)]	体质量指数（kg/m², $\bar{x}$ ±s）	火焰	热液	四肢	躯干	烧伤面积[%TBSA，M(P₂₅,P₇₅)]	换药面积[cm²，M(P₂₅,P₇₅)]
观察组	33	23	10	40(31,51)	23.28±3.32	23	10	24	13	11.39(6.00,16.00)	102.97(72.46,135.91)
对照组	33	21	12	41(30,54)	22.78±3.42	20	13	23	15	11.33(7.00,16.00)	101.87(81.42,128.83)
χ ²/Z值		0.068		-0.741	0.603	0.267		0.022		0.043	0.117
P值		0.794		0.464	0.549	0.605		0.881		0.966	0.907

组别	例数	性别（例）		年龄[岁，M(P₂₅,P₇₅)]	体质量指数（kg/m², $\bar{x}$ ±s）	烧伤原因（例）		烧伤部位（例）		烧伤面积[%TBSA，M(P₂₅,P₇₅)]	换药面积[cm²，M(P₂₅,P₇₅)]
组别	例数	男	女	年龄[岁，M(P₂₅,P₇₅)]	体质量指数（kg/m², $\bar{x}$ ±s）	火焰	热液	四肢	躯干	烧伤面积[%TBSA，M(P₂₅,P₇₅)]	换药面积[cm²，M(P₂₅,P₇₅)]
观察组	33	23	10	40(31,51)	23.28±3.32	23	10	24	13	11.39(6.00,16.00)	102.97(72.46,135.91)
对照组	33	21	12	41(30,54)	22.78±3.42	20	13	23	15	11.33(7.00,16.00)	101.87(81.42,128.83)
χ ²/Z值		0.068		-0.741	0.603	0.267		0.022		0.043	0.117
P值		0.794		0.464	0.549	0.605		0.881		0.966	0.907

组别	例数	创面愈合时间（d， $\bar{x}$ ±s）	创面感染率［例（%）］
观察组	33	12.09±1.75	3（9.09）
对照组	33	12.97±1.88	2（6.06）
t值		1.935
P值		0.057	1.000

组别	例数	创面愈合时间（d， $\bar{x}$ ±s）	创面感染率［例（%）］
观察组	33	12.09±1.75	3（9.09）
对照组	33	12.97±1.88	2（6.06）
t值		1.935
P值		0.057	1.000

组别	例数	治疗后第1～3天	治疗后第3～5天	治疗后第5～7天	治疗后第7～10天
观察组	33	6.66±1.70	21.33±6.89	73.91±17.52	99.81±0.59
对照组	33	6.97±1.67	22.66±7.07	58.91±13.30	99.72±0.92
t值		0.742	0.771	3.916	0.483
P值		0.461	0.443	＜0.001	0.631

组别	例数	治疗后第1～3天	治疗后第3～5天	治疗后第5～7天	治疗后第7～10天
观察组	33	4.45±1.05	4.79±1.07	1.94±1.17	0.53±0.50
对照组	33	4.21±1.30	5.06±1.10	2.68±1.03	0.62±0.49
t值		0.929	1.007	3.475	1.468
P值		0.357	0.318	0.001	0.142

组别	例数	色泽	血管分布	柔软度	厚度	疼痛	瘙痒	总分
观察组	33	1.81±0.77	1.75±0.83	1.88±0.82	1.54±0.60	0.39±0.49	1.39±0.55	8.73±1.71
对照组	33	2.00±0.75	1.91±0.72	2.16±0.94	1.93±0.63	0.36±0.48	1.66±0.64	9.85±1.65
t值		0.952	0.968	0.972	2.198	0.250	1.414	2.666
P值		0.344	0.337	0.334	0.032	0.803	0.162	0.010

组别	例数	色泽	血管分布	柔软度	厚度	疼痛	瘙痒	总分
观察组	33	1.18±0.57	0.58±0.49	0.70±0.63	1.09±0.67	0	0.12±0.33	3.67±1.39
对照组	33	1.45±0.66	0.70±0.46	0.73±0.57	1.27±0.57	0	0.27±0.45	4.38±1.39
t值		1.769	1.016	0.203	1.175		1.552	2.181
P值		0.082	0.313	0.840	0.244		0.126	0.047

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