| ［1］ |
Zhao M， Wang L， Wang M， et al.Targeting fibrosis， mechanisms and cilinical trials［J］.Signal Transduct Target Ther， 2022，7（1）：206.
|
| ［2］ |
Rosenbloom J， Macarak E， Piera-Velazquez S， et al.Human fibrotic diseases： current challenges in fibrosis research［J］.Methods Mol Biol， 2017，1627：1-23.
|
| ［3］ |
Qiu Z， Zhong Z， Zhang Y， et al.Human umbilical cord mesenchymal stem cell-derived exosomal miR-335-5p attenuates the inflammation and tubular epithelial-myofibroblast transdifferentiation of renal tubular epithelial cells by reducing ADAM19 protein levels［J］.Stem Cell Res Ther，2022，13（1）：373.
|
| ［4］ |
Nikolic-Paterson DJ，Wang S，Lan HY.Macrophages promote renal fibrosis through direct and indirect mechanisms［J］.Kidney Int Suppl（2011），2014，4（1）：34-38.
|
| ［5］ |
Xiong Y，Chang Y，Hao J， et al.Eplerenone attenuates fibrosis in the contralateral kidney of UUO rats by preventing macrophage-tomyofibroblast transition［J］.Front Pharmacol，2021，12：620433.
|
| ［6］ |
Tang PC， Chung JY， Xue VW， et al.Smad3 promotes cancerassociated fibroblasts generation via macrophage-myofibroblast transition［J］.Adv Sci （Weinh），2022，9（1）：e2101235.
|
| ［7］ |
Meng X， Wang S， Huang X， et al.Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis［J］.Cell Death Dis， 2016，7（12）：e2495.
|
| ［8］ |
Chen S，Saeed AFUH，Liu Q，et al.Macrophages in immunoregulation and therapeutics［J］.Signal Transduct Target Ther，2023，8（1）：207.
|
| ［9］ |
Mahdavian Delavary B，van der Veer WM，van Egmond M，et al.Macrophages in skin injury and repair［J］.Immunobiology， 2011，216（7）：753-762.
|
| ［10］ |
Tang PM，Nikolic-Paterson DJ， Lan HY.Macrophages： versatile players in renal inflammation and fibrosis［J］.Nat Rev Nephrol，2019，15（3）：144-158.
|
| ［11］ |
Wang Y，Jiang H，Pan J，et al.Macrophage-to-myofibroblast transition contributes to interstitial fibrosis in chronic renal allograft injury［J］.J Am Soc Nephrol，2017，28（7）：2053-2067.
|
| ［12］ |
Fuchs AL，Costello SM，Schiller SM，et al.Primary human M2 macrophage subtypes are distinguishable by aqueous metabolite profiles［J］.Int J Mol Sci， 2024，25（4）：2407.
|
| ［13］ |
Luo L，Wang S，Hu Y，et al.Precisely regulating M2 subtype macrophages for renal fibrosis resolution［J］.ACS Nano， 2023，17（22）：22508-22526.
|
| ［14］ |
Ruiz-Ortega M，Rayego-Mateos S，Lamas S，et al.Targeting the progression of chronic kidney disease［J］.Nat Rev Nephrol，2020，16（5）：269-288.
|
| ［15］ |
Wei J，Xu Z，Yan X.The role of the macrophage-to-myofibroblast transition in renal fibrosis［J］.Front Immunol， 2022，13：934377.
|
| ［16］ |
Zeng H，Gao Y，Yu W，et al.Pharmacological inhibition of sting/tbk1 signaling attenuates myeloid fibroblast activation and macrophage to myofibroblast transition in renal fibrosis［J］.Front Pharmacol， 2022，13：940716.
|
| ［17］ |
Yao Q，Zheng X，Zhang X，et al.METTL3 potentiates M2 macrophage-driven MMT to aggravate renal allograft fibrosis via the TGF-beta1/Smad3 pathway［J］.Adv Sci（ Weinh）， 2025，12（11）：e2412123.
|
| ［18］ |
Wang S，Meng X，Ng Y，et al.TGF-beta/Smad3 signalling regulates the transition of bone marrow-derived macrophages into myofibroblasts during tissue fibrosis［J］.Oncotarget，2016，7（8）：8809-8822.
|
| ［19］ |
Yu W， Song J， Chen S， et al.Myofibroblast-derived exosomes enhance macrophages to myofibroblasts transition and kidney fibrosi［sJ］.Renal Failure，2024，46（1）：2334406.
|
| ［20］ |
Tang P M， Zhou S， Li C， et al.The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring［J］.Kidney Int，2018，93（1）：173-187.
|
| ［21］ |
Zhou Y， Li Z， Yu S， et al.Iguratimod prevents renal fibrosis in unilateral ureteral obstruction model mice by suppressing M2 macrophage infiltration and macrophage-myofibroblast transition［J］.Ren Fail， 2024，46（1）：2327498.
|
| ［22］ |
Ninomiya K，Takahashi A，Fujioka Y， et al.Transforming growth factor-beta signaling enhances transdifferentiation of macrophages into smooth muscle-like cells［J］.Hypertens Res， 2006，29（4）：269-276.
|
| ［23］ |
Chen J，Tang Y，Zhong Y，et al.P2Y12 inhibitor clopidogrel inhibits renal fibrosis by blocking macrophage-to-myofibroblast transition［J］.Mol Ther，2022，30（9）：3017-3033.
|
| ［24］ |
Xiang T，Wang X，Huang S，et al.Inhibition of PKM2 by shikonin impedes TGF-beta1 expression by repressing histone lactylation to alleviate renal fibrosis［J］.Phytomedicine，2024，136：156324.
|
| ［25］ |
Feng Y，Guo F，Mai H， et al.Pterostilbene， a bioactive component of blueberries， alleviates renal interstitial fibrosis by inhibiting macrophage-myofibroblast transition［J］.Am J Chin Med， 2020，48（7）：1715-1729.
|
| ［26］ |
Xu L，Jiang H， Xie J， et al.Mannan-binding lectin ameliorates renal fibrosis by suppressing macrophage-to-myofibroblast transition［J］.Heliyon， 2023，9（11）：e21882.
|
| ［27］ |
Fan Z，Guan J.Antifibrotic therapies to control cardiac fibrosis［J］.Biomater Res，2016，20：13.
|
| ［28］ |
Zhang Y， Wu Y， Li M， et al.Identification of macrophage driver genes in fibrosis caused by different heart diseases based on omics integration［J］.J Transl Med，2024，22（1）：839.
|
| ［29］ |
Liu K， Jin H， Tang M， et al.Lineage tracing clarifies the cellular origin of tissue-resident macrophages in the developing hear［tJ］.J Cell Biol， 2022，221（6）：e202108093.
|
| ［30］ |
Revelo XS，Parthiban P，Chen C， et al.Cardiac resident macrophages prevent fibrosis and stimulate angiogenesis［J］.Circ Res， 2021，129（12）：1086-1101.
|
| ［31］ |
Shen S， Zhang M， Wang X， et al.Single-cell RNA sequencing reveals S100a9hi macrophages promote the transition from acute inflammation to fibrotic remodeling after myocardial ischemiareperfusion［J］.Theranostics，2024，14（3）：1241-1259.
|
| ［32］ |
Zhuang T，Chen M，Wu R，et al.ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice［J］.Nat Commun， 2024，15（1）：1995.
|
| ［33］ |
Cho HH，Rhee S，Cho DI，et al.IKKepsilon-deficient macrophages impede cardiac repair after myocardial infarction by enhancing the macrophage-myofibroblast transition［J］.Exp Mol Med，2024，56（9）：2052-2064.
|
| ［34］ |
Geng F，Xu J，Ren X，et al.Effect of macrophage-to-myofibroblast transition on silicosis［J］.Animal Model Exp Med，2025，8（2）：363-371.
|
| ［35］ |
Peng Y， Mei S， Qi X， et al.PGC-1α mediates migrasome secretion accelerating macrophage-myofibroblast transition and contributing to sepsis-associated pulmonary fibrosis［J］.Exp Mol Med， 2025，57（4）：759-774.
|
| ［36］ |
Liu H，Guan Q，Zhao P，et al.TGF-beta-induced CCR8 promoted macrophage transdifferentiation into myofibroblast-like cells［J］.Exp Lung Res， 2022：1-14.
|
| ［37］ |
Geng F， Zhao L， Cai Y， et al.Quercetin alleviates pulmonary fibrosis in silicotic mice by inhibiting macrophage transition and TGF-β-Smad2/3 pathway［J］.Curr Issues Mol Biol，2023，45（4）：3087-3101.
|
| ［38］ |
Evans S， Butler JR， Mattila JT， et al.Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophageto-myofibroblast transformation［J］.PLOS Computational Biology，2020，16（12）：e1008520.
|
| ［39］ |
Little K，Llorián-Salvador M，Tang M，et al.Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration［J］.J Neuroinflammation，2020，17（1）：355.
|
| ［40］ |
Yi C，Liu J，Deng W，et al.Macrophage elastase （MMP12）critically contributes to the development of subretinal fibrosis［J］.J Neuroinflammation，2022，19（1）：78.
|
| ［41］ |
Che Y，Chien Y，Zhu Y，et al.GSDMD-dependent neutrophil extracellular traps mediate portal vein thrombosis and associated fibrosis in cirrhosis［J］.Int J Mol Sci，2024，25（16）：9099.
|
| ［42］ |
Wang W，Xiao D，Lin L，et al.Antifibrotic effects of tetrahedral framework nucleic acids by inhibiting macrophage polarization and macrophage-myofibroblast transition in bladder remodeling［J］.Adv Healthc Mater，2023，12（11）：e2203076.
|
| ［43］ |
Tan Q，Xiang C，Zhang H，et al.YAP promotes fibrosis by regulating macrophage to myofibroblast transdifferentiation and M2 polarization in chronic pancreatiti［sJ］.Int Immunopharmacol，2025，148：114087.
|
| ［44］ |
Sun J，Shi M，Mei R，et al.LincR-PPP2R5C regulates the PP2A signaling pathway in the macrophage-myofibroblast transition in a mouse model of epidural fibrosis［J］.Mol Immunol，2025，177：85-95.
|
| ［45］ |
Zeng J，Du X，Lu Q，et al.Inhibition of GDNF-driven macrophage-tomyofibroblast transition protects against colitis-associated intestinal fibrosis［J］.Inflammation，2024.
|
| ［46］ |
Jia Y，Qin Y，Yuan F，et al.Macrophage-to-myofibroblast transition contributes to cutaneous scarring formation through the tgf-beta/smad3 signaling pathways［J］.Cell Biol Int， 2025，49（5）：494-507.
|