Pyruvic acid is the center of the metabolism of the three major nutrients, the previous studies have shown that pyruvate and its metabolites have the effect of relieved metabolism, lowering blood pressure, cholesterol, relieve fatigue and so on. In recent years, studies have shown that at the time of the treatment of burn and shock and other rehydration therapy, the addition of pyruvate has improved hematocrit shock, septic shock, ischemia and reperfusion injury, multiple organ dysfunction. It has become a new hot spot in anti-shock treatment research.In recent years, the anti-shock effect of pyruvate may be related to the inhibition of vital organs vascular permeability, reduce ischemia-reperfusion injury, protect heart, kidney, brain and intestinal function and correct lactic acidosis, reduce the activity of glutathione peroxidase in important organ, inhibition of high mobility group box-1, increased hypoxia inducible factor-1 levels increased. In this paper, recent studies on pyruvate anti-trauma, burn shock and septic shock are summarized below.