Research progress of cartilage stem/progenitor cell in joint cartilage repair

doi:10.3877/cma.j.issn.1673-9450.2022.01.013

Abstract

Abstract:

Articular cartilage injury represents is a most common athletic injury in the clinic. However, articular cartilage lacks of blood vessels and innervation, it is difficult to completely regenerate and repair itself after injury. Without effective medical intervention, it usually develops into osteoarthritis (OA). With the rapid development of tissue engineering, cartilage stem/progenitor cell (CSPC) has been found to be presented in cartilage tissue and showes great potential to develop into highly homogenous chondrocytes recently. Moreover, CSPC tends to migrate into cartilage damage site and involves in cartilage tissue repair and regeneration. These findings suggest that CSPC is one of the most promising seed cells for articular cartilage injury treatments. This article reviewes the sources, characteristics and the role and application in cartilage injury and OA of CSPC, with the purpose to propose the new insights on cartilage repair, and to exploit a novel direction in the solution to conundrums to cartilage injury.

Key words: Athletic injuries, Cartilage, articular, Osteoarthritis, Stem cell niche, Cell transplantation

Ruiqi Cao, Heyong Yin, Haomiao Yu, Lifeng Ma, Ai Guo. Research progress of cartilage stem/progenitor cell in joint cartilage repair[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2022, 17(01): 72-75.

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