Research progress on the repair of intervertebral disc degeneration with nucleus pulposus-derived mesenchymal stem cell

doi:10.3877/cma.j.issn.1673-9450.2022.03.015

Abstract

Abstract:

Mesenchymal stem cells are pluripotent stem cells with self-renewal and multi-directional differentiation capabilities. Nucleus pulposus-derived mesenchymal stem cell (NPMSC), as intervertebral disc-derived mesenchymal stem cell, has a natural advantage in adapting to the harsh microenvironment of acidity, hypoxia, hyperosmolar, abnormal compressive stress and nutritional deficiency after intervertebral disc degeneration (IDD) and can repair IDD through transplantation, endogenous activation and its own migration and recruitment. The analysis has shown that NPMSC has great potential in the endogenous repair of IDD. This paper reviews the repair strategies of IDD based on NPMSC in recent years, in order to further clarify the future research direction and provide ideas for seeking reliable treatment methods of IDD.

Key words: Intervertebral disc, Nucleus pulposus-derived mesenchymal stem cells, Intervertebral disc degeneration, Repair

Man Hu, Wenjie Zhao, Yu Zhang, Xin Liu, Pengzhi Shi, Junwu Wang, Liang Zhang. Research progress on the repair of intervertebral disc degeneration with nucleus pulposus-derived mesenchymal stem cell[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2022, 17(03): 260-264.

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