Diabetic foot ulcer （DFU） is one of the most serious chronic complications of diabetes， characterized by high disability and recurrence rates， as well as treatment resistance. DFU can lead to infection， declined functional status， hospitalization， lower limb amputation， and even death. The pathogenesis of DFU is complex， involving the interaction of multiple factors such as chronic inflammation， vascular lesions， extracellular matrix metabolism disorder， and nerve damage. Recently， the regulatory role of RNA binding proteins （RBPs） in pathogenesis of DFU has attracted increasing research interest. RBPs mediate post-transcriptional regulation of key pathological processes， such as the expression of inflammatory factors， angiogenesis， collagen metabolism， and nerve repair. Therefore， this article aims to review the mechanisms and research advances of RBPs in DFU development and progression， with a focus on their potential as therapeutic targets， thereby providing new insights for precision medicine in DFU.