Multi-omics technology is an effective collaborative multidisciplinary approach for investigating the pathogenesis and enabling precision diagnosis and treatment of burns complicated with sepsis. Complementarity is achieved by integrating multi-dimensional and interdisciplinary omics data， which clarifies the molecular network of the disease， identifies early warning indicators and molecular subtypes， and guides precision medicine and individualized interventions. Single-omics and integrated multi-omics studies, to a certain extent, have revealed the molecular characteristics of immune cell abnormalities and signaling pathway disorders, providing new ideas for early diagnosis and targeted therapy of the disease. However， challenges such as inconsistent standards， data analysis complexity， and clinical translation barriers still persist. This review summarizes the current application status and functions of multi-omics technologies， and proposes solutions to address these issues， aiming to provide references for the precision diagnosis， treatment， and prognostic evaluation of burns complicated with sepsis.