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中华损伤与修复杂志(电子版) ›› 2021, Vol. 16 ›› Issue (04) : 283 -288. doi: 10.3877/cma.j.issn.1673-9450.2021.04.002

专家述评

烧伤治疗与创面修复
姜笃银1,(), 贾珊珊2, 王兴蕾3   
  1. 1. 250012 济南,山东大学齐鲁医学院;250033 济南,山东大学第二医院整形烧伤科;250033 济南,山东大学第二医院急诊医学中心
    2. 250012 济南,山东大学齐鲁医学院
    3. 250033 济南,山东大学第二医院急诊医学中心
  • 收稿日期:2021-07-10 出版日期:2021-08-05
  • 通信作者: 姜笃银
  • 基金资助:
    国家自然科学基金资助项目(81372074,81873934); 王正国创伤医学发展基金会(生长因子复兴计划); 山东省科技攻关项目(2015GSF118041,2019GGX105011); 济南市科技发展计划(201704129)

Burn treatment and wound repair

Duyin Jiang1,(), Shanshan Jia2, Xinglei Wang3   

  1. 1. Cheeloo College of Medicine, Shandong University, Jinan 250012, China; Department of Plastic and Burns Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, China; Department of Emergency, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, China
    2. Cheeloo College of Medicine, Shandong University, Jinan 250012, China
    3. Department of Emergency, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, China
  • Received:2021-07-10 Published:2021-08-05
  • Corresponding author: Duyin Jiang
引用本文:

姜笃银, 贾珊珊, 王兴蕾. 烧伤治疗与创面修复[J]. 中华损伤与修复杂志(电子版), 2021, 16(04): 283-288.

Duyin Jiang, Shanshan Jia, Xinglei Wang. Burn treatment and wound repair[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2021, 16(04): 283-288.

烧伤创面的治疗是贯穿整个治疗过程的重要一环,影响到患者的生命、肢体功能和外观。当前医疗条件下,烧伤后因为休克而死亡的患者已经很少了,但自体皮源的缺乏、感染、创面愈合后瘢痕增生与挛缩一直是烧伤创面治疗面临的挑战。烧伤创面如何更迅速、更美观地愈合关系到患者未来生活质量,这也是烧伤治疗一直在探究的难题。本文简述烧伤创面治疗的进展、难点以及对未来可能方向的一些认识。

The treatment of burn wound is an important link throughout the whole treatment process, which affects the life, limb function and appearance of patients. Under the current medical conditions, there are few patients died of shock after burn, but the lack of autologous skin, infection, scar hyperplasia and contracture after wound healing are always challenges for burn wound treatment. The faster and more beautiful healing of burn wound is related to the quality of life of patients in the future, which is also a problem that has been explored in burn treatment. In this paper, the progress and difficulties of burn wound treatment, as well as some understanding of the possible direction in the future are briefly described.

[1]
郭振荣. 我国烧伤康复的现状与展望[J/CD]. 中华损伤与修复杂志(电子版), 2018, 13(3): 161-164.
[2]
Güldogan CE, Kendirci M, Tikici D, et al. Clinical infection in burn patients and its consequences[J]. Ulus Travma Acil Cerrahi Derg, 2017, 23(6): 466-471.
[3]
田瑞瑞,李娜,魏力. 微环境pH值对创面愈合的作用研究进展[J]. 中华烧伤杂志2016, 32(4): 240-242.
[4]
Ono S, Imai R, Ida Y, et al. Increased wound pH as an indicator of local wound infection in second degree burns[J]. Burns, 2015, 41(4): 820-824.
[5]
孙业祥. 烧伤感染的诊治进展[J]. 中国烧伤创疡杂志2019, 31(3): 186-191.
[6]
姚咏明,栾樱译. 严重烧创伤感染及其并发症的免疫新认识[J]. 中华烧伤杂志2021, 37(6): 519-523.
[7]
Seymour CW, Kennedy JN, Wang S, et al. Derivation, validation, and potential treatment implications of novel clinical phenotypes for sepsis[J]. JAMA, 2019, 321(20): 2003-2017.
[8]
Ducharme J, Self WH, Osborn TM, et al. A multi-mRNA host-response molecular blood test for the diagnosis and prognosis of acute infections and sepsis: proceedings from a clinical advisory panel[J]. J Pers Med, 2020, 10(4): 266.
[9]
张成,彭源,罗小强,等. 3 067例住院烧伤患儿流行病学调查及其感染的病原学特征分析[J]. 中华烧伤杂志2021, 37(6): 538-545.
[10]
Liu HF, Zhang F, Lineaweaver WC. History and advancement of burn treatments[J]. Ann Plast Surg, 2017, 78(2 Suppl 1): S2-S8.
[11]
Zalgeviciene V, Kulvietis V, Bulotiene D, et al. Quantum dots mediated embryotoxicity via placental damage[J]. Reprod Toxicol, 2017, 73: 222-231.
[12]
Yoisungnern T, Choi YJ, Han JW, et al. Internalization of silver nanoparticles into mouse spermatozoa results in poor fertilization and compromised embryo development[J]. Sci Rep, 2015, 5: 11170.
[13]
Qi Y, Dong Z, Chu H, et al. Denatured acellular dermal matrix seeded with bone marrow mesenchymal stem cells for wound healing in mice[J]. Burns, 2019, 45(7): 1685-1694.
[14]
中国老年医学学会烧创伤分会. 天然真皮基质应用于创面修复的全国专家共识(2020版)[J]. 中华烧伤杂志2020, 36(10): 895-900.
[15]
王曌华,赵培东,武延朋,等. 切痂植皮与削痂植皮在重度关节烧伤患者中修复效果及对微循环的影响[J]. 中国临床医生杂志2020, 48(1): 85-88.
[16]
Asai H, Maegawa N, Urisono Y, et al. A case of extensive burn injury with hypercalcemia caused by calcium ion absorption from the wound dressing[J]. Burns Open, 2020, 4(1): 28-30.
[17]
Muthukumar T, Prabu P, Ghosh K, et al. Fish scale collagen sponge incorporated with Macrotyloma uniflorum plant extract as a possible wound/burn dressing material[J]. Colloids Surf B Biointerfaces, 2014, 113: 207-212.
[18]
Singh R, Tripathi D, Jaiswal SP, et al. Use of negative pressure wound therapy as a bolster over skin grafts in patients with severe burn injuries at a tertiary care burn centre in India[J]. Burns Open, 2021, 5(3): 137-140.
[19]
Sogorski A, Lehnhardt M, Goertz O, et al. Improvement of local microcirculation through intermittent Negative Pressure Wound Therapy (NPWT)[J]. J Tissue Viability, 2018, 27(4): 267-273.
[20]
Lessing MC, James RB, Ingram SC. Comparison of the effects of different negative pressure wound therapy modes—continuous, noncontinuous, and with instillation—on porcine excisional wounds[J]. Eplasty, 2013, 13: e51.
[21]
张明良. 微粒皮移植术的回顾及展望[J]. 中华烧伤杂志2008, 24(5): 343-345.
[22]
葛绳德. Meek皮肤移植技术的创建和发展[J/CD]. 中华损伤与修复杂志(电子版), 2006, 1(1): 10-11.
[23]
王鑫,申传安,赵东旭. MEEK微型皮片移植技术的研究进展及应用[J]. 解放军医学杂志2018, 43(3): 263-267.
[24]
祁研红,刘毅. 微粒化脱细胞真皮基质研究现状[J]. 中国美容整形外科杂志2019, 30(4): 221-223,后插2页.
[25]
徐圣博,王鑫,申传安,等. 表皮细胞膜片的培养及临床应用研究进展[J/CD]. 中华损伤与修复杂志(电子版), 2019, 14(6): 455-458.
[26]
卫裴,罗鹏飞,夏照帆. 皮肤替代模式的研究现状及发展前景[J/CD]. 中华损伤与修复杂志(电子版), 2019, 14(3): 161-165.
[27]
Holmes Iv JH, Molnar JA, Carter JE, et al. A Comparative Study of the ReCell Device and Autologous Spit-thickness Meshed Skin Graft in the Treatment of Acute Burn Injuries[J]. J Burn Care Res, 2018, 39(5): 694-702.
[28]
姜耀男,王雨翔,郑勇军,等. 含异体角质形成细胞和成纤维细胞的细胞膜片治疗Ⅱ度烧伤创面的临床研究[J]. 中华烧伤杂志2020, 36(3): 171-178.
[29]
Piejko M, Radziun K, Bobis-Wozowicz S, et al. Adipose-Derived Stromal Cells Seeded on Integra Dermal Regeneration Template Improve Post-Burn Wound Reconstruction[J]. Bioengineering (Basel), 2020, 7(3): 67.
[30]
Riha SM, Maarof M, Fauzi MB. Synergistic Effect of Biomaterial and Stem Cell for Skin Tissue Engineering in Cutaneous Wound Healing: A Concise Review[J]. Polymers (Basel), 2021, 13(10): 1546.
[31]
Walter MNM, Wright KT, Fuller HR, et al. Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays[J]. Exp Cell Res, 2010, 316(7): 1271-1281.
[32]
王宏宇,刘玲英,巴特. 间充质干细胞在烧伤创面修复中的研究进展[J/CD]. 中华损伤与修复杂志(电子版), 2020, 15(6): 495-498.
[33]
蔡德南,陈斐,王木盛. 脐带间充质干细胞移植对烧伤患者新生肉芽组织EGF及VEGF表达的影响[J]. 广东医学2018, 39(5): 740-744.
[34]
Bey E, Prat M, Duhamel P, et al. Emerging therapy for improving wound repair of severe radiation burns using local bone marrow-derived stem cell administrations[J]. Wound Repair Regen, 2010, 18(1): 50-58.
[35]
Zakrzewski W, Dobrzyński M, Szymonowicz M, et al. Stem cells: past, present, and future[J]. Stem Cell Res Ther, 2019, 10(1): 68.
[36]
Han CM, Cheng B, Wu P, et al. Clinical guideline on topical growth factors for skin wounds[J]. Burns Trauma, 2020, 8: tkaa035.
[37]
Wu Y, Liang T, Hu Y, et al. 3D bioprinting of integral ADSCs-NO hydrogel scaffolds to promote severe burn wound healing[J]. Regen Biomater, 2021, 8(3): rbab014.
[38]
Zhang Y, Enhejirigala , Yao B, et al. Using bioprinting and spheroid culture to create a skin model with sweat glands and hair follicles[J]. Burns Trauma, 2021, 9: tkab013.
[39]
Shaarawy E, Hegazy RA, Abdel Hay RM. Intralesional botulinum toxin type A equally effective and better tolerated than intralesional steroid in the treatment of keloids: a randomized controlled trial[J]. J Cosmet Dermatol, 2015, 14(2): 161-166.
[40]
Kirkpatrick LD, Carney BC, Smith RD, et al. 114 Galectin-1 Is Overexpressed in Post-Burn Hypertrophic Scar[J]. J Burn Care Res, 2020, 41(Issue Supplement_1): S76-S77.
[41]
Agrawal A, Ding J, Agrawal B, et al. Stimulation of toll-like receptor pathways by burn eschar tissue as a possible mechanism for hypertrophic scarring[J]. Wound Repair Regen, 2021.
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