探讨抗生素骨水泥填充治疗糖尿病足骨髓炎（DFO）的临床疗效与安全性。

回顾性分析2023年10月至2024年10月中山源田骨科医院创面修复专科收治符合入选标准的41例DFO患者的临床资料。所有患者均接受一期彻底清创并植入抗生素骨水泥填充创腔，二期取出骨水泥后行植皮、皮瓣转移或软组织直接缝合的确定性创面修复术。其中男29例，女12例，平均年龄（60.98±8.82）岁；左足病变22例，右足病变19例。分析患者住院时间、术后复发及并发症发生情况，随访至术后6个月。

所有患者术后感染均得到有效控制，创面愈合良好，随访期间无患者创面复发。首次住院时间为（3.73±1.05）d，二期手术住院时间为（9.32±1.01）d，总住院时间为（13.05±1.34）d。术后6个月美国足踝外科协会（AOFAS）踝与后足评分为（60.02±9.05）分。

一期清创联合抗生素骨水泥植入、二期行创面确定性修复手术的治疗策略，可有效控制DFO感染并促进创面愈合。

To investigate the clinical efficacy and safety of antibiotic bone cement in the treatment of diabetic foot osteomyelitis.

A retrospective analysis was conducted on the clinical data of 41 patients with diabetic foot osteomyelitis who met the inclusion criteria and were admitted to the Department of Wound Repair Surgery, Zhongshan Yuantian Orthopedic Hospital, from October 2023 to October 2024. All patients underwent one-stage thorough debridement with implantation of antibiotic bone cement into the wound cavity, followed by two-stage removal of the bone cement and definitive wound repair using skin grafting, flap transfer, or direct softtissue closure. Among them, there were 29 males and 12 females, with a mean age of (60.98±8.82) years; 22 cases involved the left foot and 19 cases involved the right foot. The length of hospital stay, postoperative recurrence, and complications were analyzed, with a follow-up period of 6 months postoperatively.

Postoperative infection was effectively controlled in all patients, and the wounds healed satisfactorily. No recurrence was observed during the follow-up period. The duration of the first hospitalization was (3.73±1.05) days, the duration of the second hospitalization for reconstructive surgery was (9.32±1.01) days, and the total hospitalization duration was (13.05±1.34) days. The American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score at 6 months postoperatively was (60.02±9.05) points.

The treatment strategy of one-stage debridement combined with antibiotic bone cement implantation followed by two-stage definitive wound reconstructive surgery can effectively control infection and promote wound healing in diabetic foot osteomyelitis.