To observe the effects of lienal polypeptide on the immune function and wound outcome in treating diabetic foot patients of different grades.

According to the Wagner Grading System, seventy-eight eligible diabetic foot patients from two hospitals in shanghai were divided into infection treatment group (21 patients), infection control group (21 patients), gangrene treatment group (18 patients) and gangrene control group (18 patients). Infection treatment group and gangrene treatment group were given 14 days′ lienal polypeptide injection treatment from the second day after admission, while infection control group and gangrene control group were given routine treatment. Blood glucose, immune function, infection rate and prognosis were evaluated and compared between the four groups.

After treatment, the blood glucose of all groups was controlled at an acceptable level and the treatment groups consumed less insulin comparing to the control groups. The treatment groups were also exceed to the control groups in CD3 increment, CD4 increment, CD4/CD8, IgA increment, IgG increment, infection rate, treatment period, the difference was statistically significant (P<0.05). The gangrene treatment group was superior to the gangrene control group in the number of operation and amputation rate, the difference was statistically significant (P<0.05). In addition, the insulin consuming of the infection treatment group was less than that of the gangrene treatment group(51.67±10.85)IU, the difference was statistically significant(t=2.96, P=0.031). The CD4 increasing of the infection treatment group (7.16±1.13)% was more than that of the gangrene treatment group (6.49±1.51) %, the difference was statistically significant (t=2.18, P=0.037). The IgG increasing of the infection treatment group (40.12±9.65) mg/mL was more than that of the gangrene treatment group (51.67±10.85) mg/mL, the difference was statistically significant(t=3.14, P=0.007).

For the diabetic foot patients, lienal polypeptide can accelerate the recovery of immune function, reduce the infection rate, promote wound healing, shorten the treatment time and improve the prognosis. If lienal polypeptide is used in early phase, the effects can be more significant.